Protein: KU70
ATP-dependent DNA helicase II subunit 1 (EC 3.6.4.12) (ATP-dependent DNA helicase II subunit Ku70) (High affinity DNA-binding factor subunit 1)

Gene: KU70, YKU70
Organism: Saccharomyces cerevisiae S288C
Interactions: 56
UniProt ID: P32807

Gene Ontology (top 5):
GO:0000723 - telomere maintenance
GO:0000724 - double-strand break repair via homologous recombination
GO:0000725 - recombinational repair
GO:0000727 - double-strand break repair via break-induced replication
GO:0000781 - chromosome, telomeric region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

745451

KU80
ATP-dependent DNA helicase II subunit 2

12

8

Small-scale

0.975

High

550639

SIR4
Regulatory protein SIR4

4

1

Small-scale

0.691

High

745449

H3
Histone H3

3

7

Small-scale

0.670

High

745438

KU70
ATP-dependent DNA helicase II subunit 1

1

8

Small-scale

0.618

High

381035

H2B1
Histone H2B.1

2

10

High-throughput

0.601

High

381979

H4
Histone H4

2

3

High-throughput

0.601

High

419666

H2A2
Histone H2A.2

2

9

High-throughput

0.601

High

745440

PRS6B
26S proteasome regulatory subunit 6B homolog

1

1

High-throughput

0.536

High

745450

RUVB1
RuvB-like protein 1

1

4

High-throughput

0.536

High

745454

TERT
Telomerase reverse transcriptase

1

3

Small-scale

0.515

High

585162

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.513

High

740558

IME2
Meiosis induction protein kinase IME2/SME1

1

5

High-throughput

0.501

High

745441

RCK1
Serine/threonine-protein kinase RCK1

1

3

High-throughput

0.501

High

366980

ATPB
ATP synthase subunit beta, mitochondrial

1

7

High-throughput

0.500

High

392457

HSP82
ATP-dependent molecular chaperone HSP82

1

4

High-throughput

0.500

High

408307

GAL1
Galactokinase

1

1

High-throughput

0.500

High

416406

HXKA
Hexokinase-1

1

1

High-throughput

0.500

High

452863

ATPA
ATP synthase subunit alpha, mitochondrial

1

7

High-throughput

0.500

High

531288

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.500

High

592127

VATB
V-type proton ATPase subunit B

1

7

High-throughput

0.500

High

675843

MAS5
Mitochondrial protein import protein MAS5

1

4

High-throughput

0.500

High

679514

CDC48
Cell division control protein 48

1

4

High-throughput

0.500

High

745448

ACT
Actin

1

1

High-throughput

0.500

High

745447

FMP48
Probable serine/threonine-protein kinase FMP48

1

0

High-throughput

0.493

High

704676

PRR1
Serine/threonine-protein kinase PRR1

1

0

High-throughput

0.480

High

745442

NSE2
E3 SUMO-protein ligase MMS21

1

0

Small-scale

0.480

High

381462

H2B2
Histone H2B.2

1

10

High-throughput

0.479

High

419392

H2A1
Histone H2A.1

1

9

High-throughput

0.479

High

603029

EST1
Telomere elongation protein EST1

1

1

High-throughput

0.479

High

745444

MLP2
Protein MLP2

1

5

Small-scale

0.479

High

745452

POB3
FACT complex subunit POB3

1

3

High-throughput

0.479

High

745453

NHEJ1
Non-homologous end-joining protein 1

1

1

Small-scale

0.479

High

473531

FLO11
Flocculation protein FLO11

1

7

High-throughput

0.470

High

745458

SMT3
Ubiquitin-like protein SMT3

1

3

Small-scale

0.470

High

386642

TBB
Tubulin beta chain

1

1

High-throughput

0.457

High

405066

LEU3
3-isopropylmalate dehydrogenase

1

3

High-throughput

0.457

High

486105

TBA1
Tubulin alpha-1 chain

1

4

High-throughput

0.457

High

590584

HSP26
Heat shock protein 26

1

3

High-throughput

0.457

High

671605

SCJ1
DnaJ-related protein SCJ1

1

4

High-throughput

0.457

High

745445

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

2

High-throughput

0.457

High

745459

HSP42
Heat shock protein 42

1

3

High-throughput

0.457

High

523438

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.445

High

526246

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

547780

NHP6A
Non-histone chromosomal protein 6A

1

8

High-throughput

0.445

High

745443

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

647064

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.437

High

706595

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

745439

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.437

High

745455

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.437

High

745460

CMR1
DNA damage-binding protein CMR1

1

7

High-throughput

0.437

High

745456

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

4

High-throughput

0.407

High

431993

ATPF
ATP synthase subunit 4, mitochondrial

1

0

High-throughput

0.279

Low

657068

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.279

Low

745457

PEX19
Peroxisomal membrane protein import receptor PEX19

1

0

High-throughput

0.279

Low

745446

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025