Protein: PARE
DNA topoisomerase 4 subunit B (EC 5.6.2.2) (Topoisomerase IV subunit B)

Gene: PARE
Organism: Escherichia coli K-12
Interactions: 41
UniProt ID: P20083

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003918 - DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 - ATP binding
GO:0005694 - chromosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

500450

GYRB
DNA gyrase subunit B

2

6

High-throughput

0.759

High

628103

PARE
DNA topoisomerase 4 subunit B

1

6

High-throughput

0.698

High

628114

DHAK
PEP-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK

3

0

High-throughput

0.641

High

500849

PARC
DNA topoisomerase 4 subunit A

1

12

High-throughput

0.625

High

450096

RF2
Peptide chain release factor RF2

2

1

High-throughput

0.611

High

496238

CHEW
Chemotaxis protein CheW

1

0

High-throughput

0.586

High

500068

CHEY
Chemotaxis protein CheY

1

0

High-throughput

0.586

High

628117

OTNK
3-oxo-tetronate kinase

2

0

High-throughput

0.585

High

490377

COAE
Dephospho-CoA kinase

2

0

High-throughput

0.563

High

497215

FUCO
Lactaldehyde reductase

2

0

High-throughput

0.563

High

499503

YEBG
Uncharacterized protein YebG

2

0

High-throughput

0.563

High

628111

RL4
Large ribosomal subunit protein uL4

2

0

High-throughput

0.563

High

521474

SECA
Protein translocase subunit SecA

1

1

High-throughput

0.536

High

467683

ARAD
L-ribulose-5-phosphate 4-epimerase AraD

1

0

High-throughput

0.513

High

501568

THIO2
Thioredoxin 2

1

0

High-throughput

0.513

High

628106

YHCG
Putative nuclease YhcG

1

0

High-throughput

0.513

High

628109

YFJY
UPF0758 protein YfjY

1

0

High-throughput

0.513

High

493776

RS2
Small ribosomal subunit protein uS2

1

1

High-throughput

0.489

High

628108

CSGD
CsgBAC operon transcriptional regulatory protein

1

1

High-throughput

0.489

High

492748

RL1
Large ribosomal subunit protein uL1

1

1

High-throughput

0.479

High

493400

RS13
Small ribosomal subunit protein uS13

1

1

High-throughput

0.479

High

493930

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

498220

ATPA
ATP synthase subunit alpha

1

1

High-throughput

0.479

High

628107

FTSK
DNA translocase FtsK

1

5

Small-scale

0.479

High

628110

RL2
Large ribosomal subunit protein uL2

1

1

High-throughput

0.479

High

490266

CLPP
ATP-dependent Clp protease proteolytic subunit

1

0

High-throughput

0.464

High

499845

YHCC
Protein YhcC

1

0

High-throughput

0.464

High

628113

GRCA
Autonomous glycyl radical cofactor

1

0

High-throughput

0.464

High

491504

IF3
Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S]

1

0

High-throughput

0.458

High

494117

RS4
Small ribosomal subunit protein uS4

1

0

High-throughput

0.458

High

499685

FIMB
Type 1 fimbriae regulatory protein FimB

1

0

High-throughput

0.458

High

500162

DCM
DNA-cytosine methyltransferase

1

0

High-throughput

0.458

High

628105

PANC
Pantothenate synthetase

1

0

High-throughput

0.458

High

628112

YFCD
Uncharacterized Nudix hydrolase YfcD

1

0

High-throughput

0.458

High

501529

SSB
Single-stranded DNA-binding protein

1

0

High-throughput

0.426

High

628104

YIDK
Uncharacterized symporter YidK

2

0

High-throughput

0.318

High

628116

YQCE
Inner membrane protein YqcE

2

0

High-throughput

0.318

High

500697

NUOH
NADH-quinone oxidoreductase subunit H

1

0

High-throughput

0.279

Low

628115

YNBC
Uncharacterized protein YnbC

1

0

High-throughput

0.279

Low

501379

RS1
Small ribosomal subunit protein bS1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025