Protein: SECA
Protein translocase subunit SecA (EC 7.4.2.8)

Gene: SECA
Organism: Escherichia coli K-12
Interactions: 102
UniProt ID: P10408

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0006605 - protein targeting
GO:0006612 - protein targeting to membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

521470

SECA
Protein translocase subunit SecA

4

0

Small-scale

0.830

High

501474

SECY
Protein translocase subunit SecY

3

0

Small-scale

0.809

High

501471

SECG
Protein-export membrane protein SecG

2

0

Small-scale

0.759

High

501451

SECB
Protein-export protein SecB

2

0

Small-scale

0.720

High

521476

MNME
tRNA modification GTPase MnmE

2

1

High-throughput

0.618

High

496035

YBGC
Acyl-CoA thioester hydrolase YbgC

2

0

Small-scale

0.593

High

480509

MOTA
Motility protein A

2

0

High-throughput

0.585

High

521483

AAS
Bifunctional protein Aas [Includes: 2-acylglycerophosphoethanolamine acyltransferase

2

0

High-throughput

0.585

High

521507

NORV
Anaerobic nitric oxide reductase flavorubredoxin

2

0

High-throughput

0.585

High

365897

PPB
Alkaline phosphatase

2

0

Small-scale

0.577

High

492512

RL7
Large ribosomal subunit protein bL12

2

0

High-throughput

0.563

High

494742

METK
S-adenosylmethionine synthase

2

0

High-throughput

0.563

High

495914

RPOB
DNA-directed RNA polymerase subunit beta

2

0

High-throughput

0.563

High

496434

FTSZ
Cell division protein FtsZ

2

0

High-throughput

0.563

High

500538

MIND
Septum site-determining protein MinD

2

0

High-throughput

0.563

High

501124

RHO
Transcription termination factor Rho

2

0

High-throughput

0.563

High

505911

GATZ
D-tagatose-1,6-bisphosphate aldolase subunit GatZ

2

0

High-throughput

0.563

High

506251

EFTU1
Elongation factor Tu 1

1

1

High-throughput

0.561

High

521492

USPG
Universal stress protein UP12

1

1

High-throughput

0.561

High

489309

ACP
Acyl carrier protein

2

0

Small-scale

0.545

High

493762

RS2
Small ribosomal subunit protein uS2

1

1

High-throughput

0.536

High

521474

PARE
DNA topoisomerase 4 subunit B

1

1

High-throughput

0.536

High

395160

UVRD
DNA helicase II

1

0

High-throughput

0.513

High

490349

HSLU
ATP-dependent protease ATPase subunit HslU

1

0

High-throughput

0.513

High

496224

ASPG1
L-asparaginase 1

1

0

High-throughput

0.513

High

521472

NARZ
Respiratory nitrate reductase 2 alpha chain

1

0

High-throughput

0.513

High

521478

RODZ
Cytoskeleton protein RodZ

1

0

High-throughput

0.513

High

521487

NIKE
Nickel import ATP-binding protein NikE

1

0

High-throughput

0.513

High

521493

FLIJ
Flagellar FliJ protein

1

0

High-throughput

0.513

High

521500

GNGF
Putative gluconeogenesis factor

1

0

High-throughput

0.513

High

521477

MNMA
tRNA-specific 2-thiouridylase MnmA

1

0

High-throughput

0.505

High

506320

EFTU2
Elongation factor Tu 2

1

1

High-throughput

0.500

High

521491

YBGD
Uncharacterized fimbrial-like protein YbgD

1

1

High-throughput

0.494

High

521479

HOLB
DNA polymerase III subunit delta'

1

1

High-throughput

0.489

High

491325

HSCA
Chaperone protein HscA

1

1

High-throughput

0.484

High

497343

MREB
Cell shape-determining protein MreB

1

1

High-throughput

0.484

High

438996

FTSQ
Cell division protein FtsQ

1

0

Small-scale

0.480

High

501469

SECE
Protein translocase subunit SecE

1

0

Small-scale

0.480

High

501482

RPOH
RNA polymerase sigma factor RpoH

1

0

Small-scale

0.480

High

497291

ETTA
Energy-dependent translational throttle protein EttA

1

0

High-throughput

0.479

High

521504

HLDE
Bifunctional protein HldE [Includes: D-beta-D-heptose 7-phosphate kinase

1

0

High-throughput

0.479

High

521490

USPF
Universal stress protein F

1

1

High-throughput

0.479

High

489380

END4
Endonuclease 4

1

0

High-throughput

0.464

High

490822

GREA
Transcription elongation factor GreA

1

0

High-throughput

0.464

High

490892

HFQ
RNA-binding protein Hfq

1

0

High-throughput

0.464

High

491121

DNAK
Chaperone protein DnaK

1

0

High-throughput

0.464

High

491502

IF3
Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S]

1

0

High-throughput

0.464

High

492248

PYRH
Uridylate kinase

1

0

High-throughput

0.464

High

492437

RL11
Large ribosomal subunit protein uL11

1

0

High-throughput

0.464

High

496631

LDCI
Inducible lysine decarboxylase

1

0

High-throughput

0.464

High

496729

PHOL
PhoH-like protein

1

0

High-throughput

0.464

High

498386

CLPA
ATP-dependent Clp protease ATP-binding subunit ClpA

1

0

High-throughput

0.464

High

499927

RL23
Large ribosomal subunit protein uL23

1

0

High-throughput

0.464

High

500847

PARC
DNA topoisomerase 4 subunit A

1

0

High-throughput

0.464

High

501635

SYY
Tyrosine--tRNA ligase

1

0

High-throughput

0.464

High

521494

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.464

High

521495

RL22
Large ribosomal subunit protein uL22

1

0

High-throughput

0.464

High

493253

RS10
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

497939

IRAP
Anti-adapter protein IraP

1

0

High-throughput

0.458

High

521475

YJIA
Zinc chaperone YjiA

1

0

High-throughput

0.458

High

521505

MSCK
Mechanosensitive channel MscK

1

0

High-throughput

0.458

High

521506

YDJL
Uncharacterized zinc-type alcohol dehydrogenase-like protein YdjL

1

0

High-throughput

0.458

High

403259

FIMA1
Type-1 fimbrial protein, A chain

1

1

High-throughput

0.437

High

497630

RLUC
Ribosomal large subunit pseudouridine synthase C

2

0

High-throughput

0.318

High

521471

BIOB
Biotin synthase

2

0

High-throughput

0.318

High

521480

HOLD
DNA polymerase III subunit psi

2

0

High-throughput

0.318

High

521489

RLMN
Dual-specificity RNA methyltransferase RlmN

2

0

High-throughput

0.318

High

521501

YBIU
Uncharacterized protein YbiU

2

0

High-throughput

0.318

High

499153

HNS
DNA-binding protein H-NS

2

0

High-throughput

0.307

High

394003

LAMB
Maltoporin

1

0

Small-scale

0.289

High

365962

BGAL
Beta-galactosidase

1

0

High-throughput

0.279

Low

494777

SMG
Protein Smg

1

0

High-throughput

0.279

Low

499529

YECA
Uncharacterized protein YecA

1

0

High-throughput

0.279

Low

500020

AMN
AMP nucleosidase

1

0

High-throughput

0.279

Low

501428

SUBI
Sulfate-binding protein

1

0

High-throughput

0.279

Low

521481

HOLC
DNA polymerase III subunit chi

1

0

High-throughput

0.279

Low

521485

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.279

Low

521486

DUSC
tRNA-dihydrouridine(16) synthase

1

0

High-throughput

0.279

Low

521488

YEJA
Uncharacterized protein YejA

1

0

High-throughput

0.279

Low

521502

YCAO
Ribosomal protein S12 methylthiotransferase accessory factor YcaO

1

0

High-throughput

0.279

Low

496100

OMPA
Outer membrane protein A

1

0

Small-scale

0.261

Low

521482

YBIB
Uncharacterized protein YbiB

1

0

High-throughput

0.261

Low

521496

YODC
Uncharacterized protein YodC

1

0

High-throughput

0.261

Low

521497

YQJI
Transcriptional regulator YqjI

1

0

High-throughput

0.261

Low

490264

CLPP
ATP-dependent Clp protease proteolytic subunit

1

0

High-throughput

0.253

Low

494800

SSRP
SsrA-binding protein

1

0

High-throughput

0.253

Low

495402

YIHI
Der GTPase-activating protein YihI

1

0

High-throughput

0.253

Low

496288

CSPE
Cold shock-like protein CspE

1

0

High-throughput

0.253

Low

498773

ASPA
Aspartate ammonia-lyase

1

0

High-throughput

0.253

Low

500722

NUSG
Transcription termination/antitermination protein NusG

1

0

High-throughput

0.253

Low

521498

HLDD
ADP-L-glycero-D-manno-heptose-6-epimerase

1

0

High-throughput

0.253

Low

495577

TMAR
Pole-localizer protein TmaR

1

0

High-throughput

0.249

Low

495993

DARP
Dual-action ribosomal maturation protein DarP

1

0

High-throughput

0.249

Low

500112

YOAB
RutC family protein YoaB

1

0

High-throughput

0.249

Low

500265

RIMO
Ribosomal protein uS12 methylthiotransferase RimO

1

0

High-throughput

0.249

Low

500642

RRAB
Regulator of ribonuclease activity B

1

0

High-throughput

0.249

Low

521473

HYAE
Hydrogenase-1 operon protein HyaE

1

0

High-throughput

0.249

Low

521484

SFGH2
S-formylglutathione hydrolase YeiG

1

0

High-throughput

0.249

Low

521499

MBHS
Hydrogenase-1 small chain

1

0

High-throughput

0.249

Low

521503

PRET
NAD-dependent dihydropyrimidine dehydrogenase subunit PreT

1

0

High-throughput

0.249

Low

501522

SSB
Single-stranded DNA-binding protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025