Protein: RS2
Small ribosomal subunit protein uS2 (30S ribosomal protein S2)

Gene: RS2, rpsB
Organism: Escherichia coli K-12
Interactions: 206
UniProt ID: P0A7V0

Gene Ontology (top 5):
GO:0000028 - ribosomal small subunit assembly
GO:0002181 - cytoplasmic translation
GO:0003735 - structural constituent of ribosome
GO:0005737 - cytoplasm
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

493679

RS5
Small ribosomal subunit protein uS5

2

9

High-throughput

0.789

High

493754

RS1
Small ribosomal subunit protein bS1

2

3

High-throughput

0.789

High

493703

RNG
Ribonuclease G

1

1

High-throughput

0.691

High

493780

RNE
Ribonuclease E

1

1

High-throughput

0.691

High

493778

RNR
Ribonuclease R

1

2

High-throughput

0.618

High

493746

GYRA
DNA gyrase subunit A

2

1

High-throughput

0.612

High

365807

RPOD
RNA polymerase sigma factor RpoD

2

1

High-throughput

0.574

High

493834

HSCC
Chaperone protein HscC

2

8

High-throughput

0.574

High

490979

HSLO
33 kDa chaperonin

2

0

High-throughput

0.563

High

489495

CH60
Chaperonin GroEL

2

2

Small-scale

0.558

High

493837

YAJL
Protein/nucleic acid deglycase 3

2

0

Small-scale

0.547

High

365862

DPO1
DNA polymerase I

1

2

High-throughput

0.536

High

368820

SYA
Alanine--tRNA ligase

1

2

High-throughput

0.536

High

444335

ERA
GTPase Era

1

6

High-throughput

0.536

High

473252

DNAJ
Chaperone protein DnaJ

1

4

High-throughput

0.536

High

491733

LPXA
Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase

1

4

High-throughput

0.536

High

493709

GATD
Galactitol 1-phosphate 5-dehydrogenase

1

1

High-throughput

0.536

High

493741

RS15
Small ribosomal subunit protein uS15

1

3

High-throughput

0.536

High

493743

CHEY
Chemotaxis protein CheY

1

2

High-throughput

0.536

High

493762

SECA
Protein translocase subunit SecA

1

1

High-throughput

0.536

High

493765

RPOS
RNA polymerase sigma factor RpoS

1

1

High-throughput

0.536

High

493773

MURC
UDP-N-acetylmuramate--L-alanine ligase

1

1

High-throughput

0.536

High

493781

LPXD
UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

1

4

High-throughput

0.536

High

493783

MUKB
Chromosome partition protein MukB

1

2

High-throughput

0.536

High

493788

MNME
tRNA modification GTPase MnmE

1

7

High-throughput

0.536

High

493795

RAVA
Regulatory ATPase RavA

1

3

High-throughput

0.536

High

493799

AIDB
Putative acyl-CoA dehydrogenase AidB

1

2

High-throughput

0.536

High

493803

CBPA
Curved DNA-binding protein

1

2

High-throughput

0.536

High

493817

HEMW
Heme chaperone HemW

1

1

High-throughput

0.536

High

480530

GRPE
Protein GrpE

1

0

High-throughput

0.513

High

480630

RHAS
HTH-type transcriptional activator RhaS

1

0

High-throughput

0.513

High

493689

UVRC
UvrABC system protein C

1

0

High-throughput

0.513

High

493691

RLMH
Ribosomal RNA large subunit methyltransferase H

1

0

High-throughput

0.513

High

493701

BTUR
Corrinoid adenosyltransferase

1

0

High-throughput

0.513

High

493702

NAPD
Chaperone NapD

1

0

High-throughput

0.513

High

493748

TSAE
tRNA threonylcarbamoyladenosine biosynthesis protein TsaE

1

0

High-throughput

0.513

High

493763

LPXB
Lipid-A-disaccharide synthase

1

0

High-throughput

0.513

High

493764

DPO3A
DNA polymerase III subunit alpha

1

0

High-throughput

0.513

High

493786

PSS
CDP-diacylglycerol--serine O-phosphatidyltransferase PssA

1

0

High-throughput

0.513

High

493789

RIBD
Riboflavin biosynthesis protein RibD [Includes: Diaminohydroxyphosphoribosylaminopyrimidine deaminase

1

0

High-throughput

0.513

High

493812

RSGA
Small ribosomal subunit biogenesis GTPase RsgA

1

0

High-throughput

0.513

High

493816

TSAC
Threonylcarbamoyl-AMP synthase

1

0

High-throughput

0.513

High

493820

FLAV
Flavodoxin 1

1

0

High-throughput

0.513

High

493825

CUTA
Divalent-cation tolerance protein CutA

1

0

High-throughput

0.513

High

493827

GNGF
Putative gluconeogenesis factor

1

0

High-throughput

0.513

High

491583

KPRS
Ribose-phosphate pyrophosphokinase

1

1

High-throughput

0.500

High

493760

EFTU2
Elongation factor Tu 2

1

5

High-throughput

0.500

High

368786

SYW
Tryptophan--tRNA ligase

1

2

High-throughput

0.489

High

395067

DNAA
Chromosomal replication initiator protein DnaA

1

1

High-throughput

0.489

High

395140

UVRD
DNA helicase II

1

4

High-throughput

0.489

High

450089

RF2
Peptide chain release factor RF2

1

3

High-throughput

0.489

High

460396

SYL
Leucine--tRNA ligase

1

4

High-throughput

0.489

High

466608

ILVB
Acetolactate synthase isozyme 1 large subunit

1

6

High-throughput

0.489

High

469920

RECB
RecBCD enzyme subunit RecB

1

1

High-throughput

0.489

High

491338

HTPG
Chaperone protein HtpG

1

7

High-throughput

0.489

High

493694

PRMA
Ribosomal protein L11 methyltransferase

1

1

High-throughput

0.489

High

493707

ADHE
Bifunctional aldehyde-alcohol dehydrogenase AdhE

1

1

High-throughput

0.489

High

493713

RLUC
Ribosomal large subunit pseudouridine synthase C

1

4

High-throughput

0.489

High

493720

ATPB
ATP synthase subunit beta

1

5

High-throughput

0.489

High

493731

GLMU
Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase

1

3

High-throughput

0.489

High

493768

DNLJ
DNA ligase

1

2

High-throughput

0.489

High

493769

SRLR
Glucitol operon repressor

1

1

High-throughput

0.489

High

493776

PARE
DNA topoisomerase 4 subunit B

1

1

High-throughput

0.489

High

493779

SRMB
ATP-dependent RNA helicase SrmB

1

11

High-throughput

0.489

High

493782

MURE
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

1

1

High-throughput

0.489

High

493792

GREB
Transcription elongation factor GreB

1

1

High-throughput

0.489

High

493805

CSPB
Cold shock-like protein CspB

1

10

High-throughput

0.489

High

493808

RLUB
Ribosomal large subunit pseudouridine synthase B

1

4

High-throughput

0.489

High

493810

XNI
Flap endonuclease Xni

1

1

High-throughput

0.489

High

493813

HRPA
ATP-dependent RNA helicase HrpA

1

1

High-throughput

0.489

High

493824

YQCA
Flavodoxin YqcA

1

1

High-throughput

0.489

High

493826

HDA
DnaA regulatory inactivator Hda

1

1

High-throughput

0.489

High

493830

DMLR
HTH-type transcriptional regulator DmlR

1

1

High-throughput

0.489

High

493835

PGRR
HTH-type transcriptional regulator PgrR

1

1

High-throughput

0.489

High

490800

GREA
Transcription elongation factor GreA

1

1

High-throughput

0.484

High

491007

DNAK
Chaperone protein DnaK

1

7

High-throughput

0.484

High

492059

IPYR
Inorganic pyrophosphatase

1

1

High-throughput

0.484

High

493681

RPOA
DNA-directed RNA polymerase subunit alpha

1

1

High-throughput

0.484

High

493692

SYT
Threonine--tRNA ligase

1

3

High-throughput

0.484

High

493693

SYK2
Lysine--tRNA ligase, heat inducible

1

5

High-throughput

0.484

High

493705

LON
Lon protease

1

2

High-throughput

0.484

High

493708

FTSE
Cell division ATP-binding protein FtsE

1

1

High-throughput

0.484

High

493710

ULAR
HTH-type transcriptional regulator UlaR

1

1

High-throughput

0.484

High

493722

CLPA
ATP-dependent Clp protease ATP-binding subunit ClpA

1

9

High-throughput

0.484

High

493747

GYRB
DNA gyrase subunit B

1

1

High-throughput

0.484

High

493750

PARC
DNA topoisomerase 4 subunit A

1

1

High-throughput

0.484

High

493818

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.484

High

493822

CLPB
Chaperone protein ClpB

1

7

High-throughput

0.484

High

490662

FABZ
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

1

0

High-throughput

0.464

High

491921

RPPH
RNA pyrophosphohydrolase

1

0

High-throughput

0.464

High

492165

PTH
Peptidyl-tRNA hydrolase

1

0

High-throughput

0.464

High

493699

FTSZ
Cell division protein FtsZ

1

0

High-throughput

0.464

High

493700

LDCI
Inducible lysine decarboxylase

1

0

High-throughput

0.464

High

493718

ALF
Fructose-bisphosphate aldolase class 2

1

0

High-throughput

0.464

High

493725

5FCL
5-formyltetrahydrofolate cyclo-ligase

1

0

High-throughput

0.464

High

493756

YHBY
RNA-binding protein YhbY

1

0

High-throughput

0.464

High

493757

IBPA
Small heat shock protein IbpA

1

0

High-throughput

0.464

High

493759

EFTU1
Elongation factor Tu 1

1

5

High-throughput

0.445

High

490243

CLPP
ATP-dependent Clp protease proteolytic subunit

1

1

High-throughput

0.442

High

490475

HSCB
Co-chaperone protein HscB

1

1

High-throughput

0.442

High

490559

DER
GTPase Der

1

11

High-throughput

0.442

High

491478

IF3
Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S]

1

1

High-throughput

0.442

High

491808

MURA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase

1

2

High-throughput

0.442

High

493683

RUVB
Holliday junction branch migration complex subunit RuvB

1

6

High-throughput

0.442

High

493690

TRMB
tRNA

1

1

High-throughput

0.442

High

493697

CSPD
Cold shock-like protein CspD

1

10

High-throughput

0.442

High

493698

CSPG
Cold shock-like protein CspG

1

10

High-throughput

0.442

High

493706

DEAD
ATP-dependent RNA helicase DeaD

1

9

High-throughput

0.442

High

493711

CSPC
Cold shock-like protein CspC

1

10

High-throughput

0.442

High

493714

RSUA
Ribosomal small subunit pseudouridine synthase A

1

3

High-throughput

0.442

High

493721

FTSA
Cell division protein FtsA

1

3

High-throughput

0.442

High

493742

MAP1
Methionine aminopeptidase

1

1

High-throughput

0.442

High

493753

RHO
Transcription termination factor Rho

1

5

High-throughput

0.442

High

493755

SRP54
Signal recognition particle protein

1

1

High-throughput

0.442

High

493758

RLME
Ribosomal RNA large subunit methyltransferase E

1

2

High-throughput

0.442

High

493819

LEPA
Elongation factor 4

1

9

High-throughput

0.442

High

493821

RLMB
23S rRNA

1

1

High-throughput

0.442

High

493732

MBHM
Hydrogenase-2 large chain

2

0

High-throughput

0.319

High

493686

TIG
Trigger factor

2

0

Small-scale

0.297

High

367439

TRPE
Anthranilate synthase component 1

1

0

High-throughput

0.279

Low

368948

SYGA
Glycine--tRNA ligase alpha subunit

1

0

High-throughput

0.279

Low

444242

BTUE
Thioredoxin/glutathione peroxidase BtuE

1

0

High-throughput

0.279

Low

449900

CCA
Multifunctional CCA protein [Includes: CCA-adding enzyme

1

0

High-throughput

0.279

Low

490123

CH10
Co-chaperonin GroES

1

0

High-throughput

0.279

Low

490327

HSLU
ATP-dependent protease ATPase subunit HslU

1

0

High-throughput

0.279

Low

493684

SMG
Protein Smg

1

0

High-throughput

0.279

Low

493695

YQGE
UPF0301 protein YqgE

1

0

High-throughput

0.279

Low

493696

CHEW
Chemotaxis protein CheW

1

0

High-throughput

0.279

Low

493712

GLNB
Nitrogen regulatory protein P-II 1

1

0

High-throughput

0.279

Low

493717

YCGL
Protein YcgL

1

0

High-throughput

0.279

Low

493719

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.279

Low

493724

FLIL
Flagellar protein FliL

1

0

High-throughput

0.279

Low

493726

SDHA
Succinate dehydrogenase flavoprotein subunit

1

0

High-throughput

0.279

Low

493727

GLRX4
Glutaredoxin 4

1

0

High-throughput

0.279

Low

493729

DNAB
Replicative DNA helicase DnaB

1

0

High-throughput

0.279

Low

493730

ERPA
Iron-sulfur cluster insertion protein ErpA

1

0

High-throughput

0.279

Low

493734

HSLR
Heat shock protein 15

1

0

High-throughput

0.279

Low

493735

YMJA
Uncharacterized protein YmjA

1

0

High-throughput

0.279

Low

493736

YECA
Uncharacterized protein YecA

1

0

High-throughput

0.279

Low

493737

EDD
Phosphogluconate dehydratase

1

0

High-throughput

0.279

Low

493738

YIBA
Protein YibA

1

0

High-throughput

0.279

Low

493740

MLAC
Intermembrane phospholipid transport system binding protein MlaC

1

0

High-throughput

0.279

Low

493745

FKBX
FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.279

Low

493766

TOP3
DNA topoisomerase 3

1

0

High-throughput

0.279

Low

493767

RECE
Exodeoxyribonuclease 8

1

0

High-throughput

0.279

Low

493770

MALQ
4-alpha-glucanotransferase

1

0

High-throughput

0.279

Low

493771

ICLR
Transcriptional repressor IclR

1

0

High-throughput

0.279

Low

493772

MURG
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

1

0

High-throughput

0.279

Low

493774

PNCB
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.279

Low

493775

MINC
Septum site-determining protein MinC

1

0

High-throughput

0.279

Low

493777

SPEA
Biosynthetic arginine decarboxylase

1

0

High-throughput

0.279

Low

493784

MURI
Glutamate racemase

1

0

High-throughput

0.279

Low

493785

ISPA
Farnesyl diphosphate synthase

1

0

High-throughput

0.279

Low

493787

YICC
Endoribonuclease YicC

1

0

High-throughput

0.279

Low

493790

MSYB
Acidic protein MsyB

1

0

High-throughput

0.279

Low

493791

HOLC
DNA polymerase III subunit chi

1

0

High-throughput

0.279

Low

493793

FLIH
Flagellar assembly protein FliH

1

0

High-throughput

0.279

Low

493794

GLMM
Phosphoglucosamine mutase

1

0

High-throughput

0.279

Low

493796

FRVX
Putative aminopeptidase FrvX

1

0

High-throughput

0.279

Low

493797

YIIS
UPF0381 protein YiiS

1

0

High-throughput

0.279

Low

493798

FDHD
Sulfur carrier protein FdhD

1

0

High-throughput

0.279

Low

493800

LLDD
L-lactate dehydrogenase

1

0

High-throughput

0.279

Low

493802

DUSC
tRNA-dihydrouridine(16) synthase

1

0

High-throughput

0.279

Low

493804

RLMN
Dual-specificity RNA methyltransferase RlmN

1

0

High-throughput

0.279

Low

493806

YCHJ
UPF0225 protein YchJ

1

0

High-throughput

0.279

Low

493807

DCTR
HTH-type transcriptional regulator DctR

1

0

High-throughput

0.279

Low

493809

RTCR
Transcriptional regulatory protein RtcR

1

0

High-throughput

0.279

Low

493811

YJEJ
Uncharacterized protein YjeJ

1

0

High-throughput

0.279

Low

493814

YHBQ
UPF0213 protein YhbQ

1

0

High-throughput

0.279

Low

493815

YFAL
Probable autotransporter YfaL [Cleaved into: Probable secreted autotransporter protein YfaL; Probable autotransporter YfaL translocator]

1

0

High-throughput

0.279

Low

493823

YDIZ
Uncharacterized protein YdiZ

1

0

High-throughput

0.279

Low

493828

YBJX
Uncharacterized protein YbjX

1

0

High-throughput

0.279

Low

493829

YCGY
Uncharacterized protein YcgY

1

0

High-throughput

0.279

Low

493831

MSRC
Free methionine-R-sulfoxide reductase

1

0

High-throughput

0.279

Low

493832

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.279

Low

493833

LYSAC
Peptidyl-lysine N-acetyltransferase PatZ

1

0

High-throughput

0.279

Low

493836

YDHQ
Protein YdhQ

1

0

High-throughput

0.279

Low

493838

YAFP
Uncharacterized N-acetyltransferase YafP

1

0

High-throughput

0.279

Low

457162

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.269

Low

493744

DSBA
Thiol:disulfide interchange protein DsbA

1

0

High-throughput

0.269

Low

493801

FLGK
Flagellar hook-associated protein 1

1

0

High-throughput

0.269

Low

490629

FABA
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

1

0

High-throughput

0.253

Low

490697

FIS
DNA-binding protein Fis

1

0

High-throughput

0.253

Low

490772

RSMG
Ribosomal RNA small subunit methyltransferase G

1

0

High-throughput

0.253

Low

490858

HFQ
RNA-binding protein Hfq

1

0

High-throughput

0.253

Low

490919

IHFA
Integration host factor subunit alpha

1

0

High-throughput

0.253

Low

491533

KDSA
2-dehydro-3-deoxyphosphooctonate aldolase

1

0

High-throughput

0.253

Low

491963

NUSB
Transcription antitermination protein NusB

1

0

High-throughput

0.253

Low

492025

PLSB
Glycerol-3-phosphate acyltransferase

1

0

High-throughput

0.253

Low

492223

PYRH
Uridylate kinase

1

0

High-throughput

0.253

Low

493680

RNPA
Ribonuclease P protein component

1

0

High-throughput

0.253

Low

493682

RPOZ
DNA-directed RNA polymerase subunit omega

1

0

High-throughput

0.253

Low

493685

SSRP
SsrA-binding protein

1

0

High-throughput

0.253

Low

493687

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.253

Low

493688

YACL
UPF0231 protein YacL

1

0

High-throughput

0.253

Low

493704

PHOL
PhoH-like protein

1

0

High-throughput

0.253

Low

493715

YBAK
Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase YbaK

1

0

High-throughput

0.253

Low

493716

YBCJ
Putative RNA-binding protein YbcJ

1

0

High-throughput

0.253

Low

493723

HOLE
DNA polymerase III subunit theta

1

0

High-throughput

0.253

Low

493728

KDTA
3-deoxy-D-manno-octulosonic acid transferase

1

0

High-throughput

0.253

Low

493733

HNS
DNA-binding protein H-NS

1

0

High-throughput

0.253

Low

493739

YIBL
Uncharacterized protein YibL

1

0

High-throughput

0.253

Low

493749

NUSG
Transcription termination/antitermination protein NusG

1

0

High-throughput

0.253

Low

493751

ATL
DNA base-flipping protein

1

0

High-throughput

0.253

Low

493752

SPOT
Bifunctional

1

0

High-throughput

0.253

Low

493761

RCSA
Transcriptional regulatory protein RcsA

1

0

High-throughput

0.253

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025