HitPredict

Interactor 1: PAK2 (Q13177)
Serine/threonine-protein kinase PAK 2 (EC 2.7.11.1) (Gamma-PAK) (PAK65) (S6/H4 kinase) (p21-activated kinase 2) (PAK-2) (p58) [Cleaved into: PAK-2p27 (p27); PAK-2p34 (p34) (C-t-PAK2)]
Gene: PAK2

Interactor 2: FSD1 (Q9BTV5)
Fibronectin type III and SPRY domain-containing protein 1 (MID1-related protein 1) (Microtubule-associated protein GLFND)
Gene: FSD1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	1.00	0.861

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~fn3
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 524 Hs			1 496
+	Hs
		1026219 PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63		FSD1_HUMAN (1-496): 6.65e-149: 436: 100.00
+	Hs
		1026923 PAK2_HUMAN (1-524): 0: 538: 100.00		TRI67_HUMAN (1-486): 7e-89: 290: 22.29
+	Hs
		536810 PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63		TRI27_HUMAN (9-494): 1.06e-93: 295: 12.96
+	Hs
		1026180 PAK1_HUMAN (1-523): 6.81e-169: 490: 74.63		TRI67_HUMAN (1-486): 7e-89: 290: 22.29
+	Hs
		682189 AKT2_HUMAN (141-523): 2.01e-138: 410: 22.79		TRI67_HUMAN (1-486): 7e-89: 290: 22.29
+	Hs
		681909 AKT1_HUMAN (141-523): 1.99e-133: 397: 21.83		TRI67_HUMAN (1-486): 7e-89: 290: 22.29
+	Hs
		568710 KAPCA_HUMAN (207-520): 9.62e-131: 385: 22.91		TRI67_HUMAN (1-486): 7e-89: 290: 22.29
+	Hs
		610741 KAPCB_HUMAN (207-524): 1.39e-130: 385: 22.94		TRI67_HUMAN (1-486): 7e-89: 290: 22.29
+	Hs
		1027387 STK3_HUMAN (224-524): 1.89e-125: 377: 41.25		TRI67_HUMAN (1-486): 7e-89: 290: 22.29
+	Hs
		1023065 STK4_HUMAN (221-518): 9.32e-125: 375: 40.00		TRI67_HUMAN (1-486): 7e-89: 290: 22.29
+	Hs
		568758 KAPCA_HUMAN (207-520): 9.62e-131: 385: 22.91		TRI63_HUMAN (4-161): 9.74e-50: 175: 27.04
+	Hs
		537109 STK26_HUMAN (241-513): 3.68e-66: 221: 45.09		TRI27_HUMAN (9-494): 1.06e-93: 295: 12.96
+	Hs
		568786 KAPCA_HUMAN (207-520): 9.62e-131: 385: 22.91		TRI55_HUMAN (1-163): 4.12e-32: 131: 21.95
+	Hs
		1172483 STK24_HUMAN (243-513): 1.32e-65: 221: 45.06		TRI67_HUMAN (1-486): 7e-89: 290: 22.29
+	Hs
		131546 STK25_HUMAN (244-513): 7.96e-64: 215: 44.12		TRI27_HUMAN (9-494): 1.06e-93: 295: 12.96
+	Hs
		331033 PAK4_HUMAN (67-236): 2.65e-10: 64.9: 21.55		TRI67_HUMAN (1-486): 7e-89: 290: 22.29
+	Hs
		331090 PAK4_HUMAN (67-236): 2.65e-10: 64.9: 21.55		TRI36_HUMAN (1-480): 1.1e-78: 262: 22.66
+	Hs
		331009 PAK4_HUMAN (67-236): 2.65e-10: 64.9: 21.55		TRI25_HUMAN (3-469): 1.48e-78: 259: 18.49