Protein: PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-3) (Phospholipase C-delta-3) (PLC-delta-3)

Gene: PLCD3
Organism: Homo sapiens
Interactions: 127
UniProt ID: Q8N3E9

Gene Ontology (top 5):
GO:0001525 - angiogenesis
GO:0004435 - phosphatidylinositol-4,5-bisphosphate phospholipase C activity
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0016042 - lipid catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1279139

RHG22
Rho GTPase-activating protein 22

2

2

High-throughput

0.811

High

407658

S100B
Protein S100-B

1

1

High-throughput

0.691

High

682546

S100P
Protein S100-P

1

1

High-throughput

0.691

High

1249810

BTNL9
Butyrophilin-like protein 9

1

3

High-throughput

0.691

High

1325105

ARI1
E3 ubiquitin-protein ligase ARIH1

3

4

High-throughput

0.667

High

871975

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

3

3

High-throughput

0.662

High

426960

FGF1
Fibroblast growth factor 1

1

0

High-throughput

0.656

High

1325070

LRC46
Leucine-rich repeat-containing protein 46

4

1

High-throughput

0.630

High

230648

PRIC3
Prickle planar cell polarity protein 3

2

2

High-throughput

0.628

High

1153473

EFNB3
Ephrin-B3

2

1

High-throughput

0.628

High

169257

CASQ2
Calsequestrin-2

2

2

High-throughput

0.611

High

1325082

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

2

1

High-throughput

0.611

High

1325055

GP156
Probable G-protein coupled receptor 156

2

0

High-throughput

0.602

High

391346

FRIL
Ferritin light chain

2

1

High-throughput

0.601

High

1145270

RNPS1
RNA-binding protein with serine-rich domain 1

2

1

High-throughput

0.601

High

1325061

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

2

High-throughput

0.601

High

1278757

HDGR2
Hepatoma-derived growth factor-related protein 2

2

0

High-throughput

0.576

High

1325071

SAHH3
Adenosylhomocysteinase 3

2

1

High-throughput

0.574

High

1325086

GPBL1
Vasculin-like protein 1

2

1

High-throughput

0.574

High

396497

ESR1
Estrogen receptor

2

4

High-throughput

0.571

High

1325089

ANLN
Anillin

1

1

High-throughput

0.553

High

171274

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

3

High-throughput

0.536

High

175905

SET1A
Histone-lysine N-methyltransferase SETD1A

1

2

High-throughput

0.536

High

230064

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

1

High-throughput

0.536

High

572943

INSRR
Insulin receptor-related protein

1

20

High-throughput

0.536

High

674244

BRD2
Bromodomain-containing protein 2

1

4

High-throughput

0.536

High

760474

SDC2
Syndecan-2

1

1

High-throughput

0.536

High

997851

CSK21
Casein kinase II subunit alpha

1

1

High-throughput

0.536

High

1006148

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

3

High-throughput

0.536

High

1022907

EFNB1
Ephrin-B1

1

1

High-throughput

0.536

High

1121822

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

3

High-throughput

0.536

High

1129922

KANK1
KN motif and ankyrin repeat domain-containing protein 1

1

3

High-throughput

0.536

High

1134486

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

2

High-throughput

0.536

High

1243755

FXL19
F-box/LRR-repeat protein 19

1

3

High-throughput

0.536

High

1250492

RBP10
Ran-binding protein 10

1

5

High-throughput

0.536

High

1325053

SYNPO
Synaptopodin

1

1

High-throughput

0.536

High

1325056

VANG1
Vang-like protein 1

1

1

High-throughput

0.536

High

1325058

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

3

High-throughput

0.536

High

1325059

IGDC4
Immunoglobulin superfamily DCC subclass member 4

1

1

High-throughput

0.536

High

1325068

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1325074

DCAF5
DDB1- and CUL4-associated factor 5

1

2

High-throughput

0.536

High

1325084

WDR26
WD repeat-containing protein 26

1

2

High-throughput

0.536

High

1325099

TNIK
TRAF2 and NCK-interacting protein kinase

1

3

High-throughput

0.536

High

1325100

VANG2
Vang-like protein 2

1

1

High-throughput

0.536

High

1325104

DCAF1
DDB1- and CUL4-associated factor 1

1

1

High-throughput

0.536

High

1325106

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

4

High-throughput

0.536

High

130985

HIP1
Huntingtin-interacting protein 1

1

0

High-throughput

0.513

High

239128

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.513

High

659533

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.513

High

718427

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.513

High

881794

DHYS
Deoxyhypusine synthase

1

0

High-throughput

0.513

High

1244523

SHQ1
Protein SHQ1 homolog

1

0

High-throughput

0.513

High

1244989

TRAT1
T-cell receptor-associated transmembrane adapter 1

1

0

High-throughput

0.513

High

1294141

TCAM2
TIR domain-containing adapter molecule 2

1

0

High-throughput

0.513

High

1325060

TP4AP
Short transient receptor potential channel 4-associated protein

1

0

High-throughput

0.513

High

1325062

GEMI6
Gem-associated protein 6

1

0

High-throughput

0.513

High

1325063

IFT81
Intraflagellar transport protein 81 homolog

1

0

High-throughput

0.513

High

1325067

TR19L
Tumor necrosis factor receptor superfamily member 19L

1

0

High-throughput

0.513

High

1325072

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.513

High

1325076

OPALI
Opalin

1

0

High-throughput

0.513

High

1325079

OSBL6
Oxysterol-binding protein-related protein 6

1

0

High-throughput

0.513

High

1325080

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1325083

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

1325091

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.513

High

1325098

DDX20
Probable ATP-dependent RNA helicase DDX20

1

0

High-throughput

0.513

High

158848

AP3D1
AP-3 complex subunit delta-1

1

1

High-throughput

0.489

High

260176

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.489

High

269785

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

1

4

High-throughput

0.489

High

604697

UBF1
Nucleolar transcription factor 1

1

3

High-throughput

0.489

High

625488

CSK22
Casein kinase II subunit alpha'

1

2

High-throughput

0.489

High

839904

AF9
Protein AF-9

1

5

High-throughput

0.489

High

848676

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.489

High

908283

AFF1
AF4/FMR2 family member 1

1

4

High-throughput

0.489

High

922545

AP3M2
AP-3 complex subunit mu-2

1

1

High-throughput

0.489

High

936608

ELL
RNA polymerase II elongation factor ELL

1

2

High-throughput

0.489

High

1040737

ENL
Protein ENL

1

4

High-throughput

0.489

High

1105048

TCOF
Treacle protein

1

6

High-throughput

0.489

High

1141215

BRD3
Bromodomain-containing protein 3

1

5

High-throughput

0.489

High

1186491

CHD9
Chromodomain-helicase-DNA-binding protein 9

1

3

High-throughput

0.489

High

1249387

CWC27
Spliceosome-associated protein CWC27 homolog

1

1

High-throughput

0.489

High

1325054

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

1

1

High-throughput

0.489

High

1325065

AP3S1
AP-3 complex subunit sigma-1

1

2

High-throughput

0.489

High

1325077

MINT
Msx2-interacting protein

1

2

High-throughput

0.489

High

1325085

ELL3
RNA polymerase II elongation factor ELL3

1

2

High-throughput

0.489

High

1325087

CWC22
Pre-mRNA-splicing factor CWC22 homolog

1

1

High-throughput

0.489

High

1325088

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

3

High-throughput

0.489

High

1325090

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.489

High

1325092

WDR70
WD repeat-containing protein 70

1

1

High-throughput

0.489

High

1325094

ARL15
ADP-ribosylation factor-like protein 15

1

3

High-throughput

0.489

High

1325097

AFF4
AF4/FMR2 family member 4

1

4

High-throughput

0.489

High

1325102

AP3M1
AP-3 complex subunit mu-1

1

1

High-throughput

0.489

High

555509

SKIL
Ski-like protein

1

0

High-throughput

0.486

High

898247

R144A
E3 ubiquitin-protein ligase RNF144A

1

2

Small-scale

0.479

High

1140549

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

1254619

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.479

High

1325096

HDAC6
Protein deacetylase HDAC6

1

2

High-throughput

0.479

High

482510

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

138852

STK25
Serine/threonine-protein kinase 25

1

3

High-throughput

0.445

High

182657

GP182
G-protein coupled receptor 182

1

2

High-throughput

0.445

High

616776

SDC1
Syndecan-1

1

1

High-throughput

0.445

High

1113677

CUL3
Cullin-3

1

1

High-throughput

0.445

High

1214236

KANK4
KN motif and ankyrin repeat domain-containing protein 4

1

2

High-throughput

0.445

High

1215324

DCAF8
DDB1- and CUL4-associated factor 8

1

2

High-throughput

0.445

High

372561

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

1325066

ESR2
Estrogen receptor beta

1

4

High-throughput

0.437

High

564048

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

1325078

ABHEA
Protein ABHD14A

1

0

High-throughput

0.426

High

1325081

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

848799

MAGAA
Melanoma-associated antigen 10

1

1

High-throughput

0.407

High

1151484

IKBB
NF-kappa-B inhibitor beta

1

2

High-throughput

0.407

High

1325073

EAF1
ELL-associated factor 1

4

0

High-throughput

0.360

High

1325057

ZCH10
Zinc finger CCHC domain-containing protein 10

2

0

High-throughput

0.313

High

126144

AP3B1
AP-3 complex subunit beta-1

1

0

High-throughput

0.279

Low

167101

GEMI2
Gem-associated protein 2

1

0

High-throughput

0.279

Low

329769

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

1

0

High-throughput

0.279

Low

1147954

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.279

Low

1312854

GPAM1
GPALPP motifs-containing protein 1

1

0

High-throughput

0.279

Low

1325064

RTF1
RNA polymerase-associated protein RTF1 homolog

1

0

High-throughput

0.279

Low

1325069

ARK2N
Protein ARK2N

1

0

High-throughput

0.279

Low

1325075

IFT74
Intraflagellar transport protein 74 homolog

1

0

High-throughput

0.279

Low

1325095

CXXC1
CXXC-type zinc finger protein 1

1

0

High-throughput

0.279

Low

1325101

EPDR1
Mammalian ependymin-related protein 1

1

0

High-throughput

0.279

Low

1325103

IFT52
Intraflagellar transport protein 52 homolog

1

0

High-throughput

0.279

Low

884363

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.249

Low

1137854

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.249

Low

1211072

PR15B
Protein phosphatase 1 regulatory subunit 15B

1

0

High-throughput

0.232

Low

1325093

CUED1
CUE domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025