HitPredict

Interactor 1: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2

Interactor 2: CRDL1 (Q9BU40)
Chordin-like protein 1 (Neuralin-1) (Neurogenesin-1) (Ventroptin)
Gene: CHRDL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0005886 - plasma membrane GO:0030509 - BMP signaling pathway
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2471 Hs			1 456
+	Hs
		1047673 NOTC2_HUMAN (22-2471): 0: 1400: 100.00		PXDN_HUMAN (130-178): 2.13e-12: 71.5: 38.78
+	Hs
		937387 NOTC2_HUMAN (22-2471): 0: 1400: 100.00		LAMB2_HUMAN (85-327): 1.12e-10: 66.1: 13.67
+	Hs
		1047635 NOTC2_HUMAN (22-2471): 0: 1400: 100.00		BMPER_HUMAN (140-326): 2.53e-10: 64.6: 20.00
+	Hs
		183243 NOTC2_HUMAN (22-2471): 0: 1400: 100.00		LAMA5_HUMAN (13-238): 1.87e-09: 62.3: 11.74
+	Dm
		451955 NOTCH_DROME (2-871): 3.92e-108: 390: 32.69		Q9W2H2_DROME (62-332): 1.45e-14: 78: 17.46
+	Dm
		451745 NOTCH_DROME (2-871): 3.92e-108: 390: 32.69		LAMA_DROME (14-238): 1.6e-10: 65.8: 10.22
+	Dm
		451718 NOTCH_DROME (2-871): 3.92e-108: 390: 32.69		LAMC1_DROME (64-297): 2.13e-09: 61.9: 11.11
+	Hs
		384135 ANK2_HUMAN (1719-2317): 5.19e-108: 390: 14.51		CO1A1_HUMAN (37-113): 5.31e-09: 60.7: 28.21
+	Hs
		274184 ANR17_HUMAN (1801-2469): 2.56e-69: 262: 17.34		FRAS1_HUMAN (10-357): 6.78e-13: 73.5: 10.14
+	Dm
		262782 Q0KIE7_DROME (1917-2288): 7.05e-60: 230: 16.35		TENM_DROME (164-372): 1.56e-19: 94.3: 9.80
+	Dm
		535775 Q0KIE7_DROME (1917-2288): 7.05e-60: 230: 16.35		LAMB1_DROME (103-393): 4.28e-09: 61.1: 10.07
+	Hs
		464436 JAG1_HUMAN (1070-1552): 3.46e-37: 156: 20.04		TSP1_HUMAN (111-357): 7.29e-11: 66.5: 15.00
+	Ce
		110246 G5EFX3_CAEEL (936-1546): 8.73e-24: 113: 21.34		G5EBZ2_CAEEL (7-329): 5.59e-11: 66.9: 13.93
+	Dm
		262723 SERR_DROME (19-162): 5.24e-09: 64.1: 26.14		TENM_DROME (164-372): 1.56e-19: 94.3: 9.80
+	Hs
		517110 NT2NC_HUMAN (1194-1404): 5.16e-17: 85.9: 33.92		CHRD_HUMAN (15-120): 1.15e-09: 62.6: 27.12
+	Hs
		1277405 NT2NA_HUMAN (34-171): 1.95e-14: 77: 38.57		CHRD_HUMAN (15-120): 1.15e-09: 62.6: 27.12
+	Hs
		464423 FBN2_HUMAN (1091-1658): 7.87e-11: 70.3: 13.74		TSP1_HUMAN (111-357): 7.29e-11: 66.5: 15.00
+	Hs
		772334 FBN2_HUMAN (1091-1658): 7.87e-11: 70.3: 13.74		VWCE_HUMAN (97-332): 1.24e-10: 65.7: 17.30
+	Hs
		464422 FBN1_HUMAN (1091-1658): 6.97e-10: 67.3: 13.58		TSP1_HUMAN (111-357): 7.29e-11: 66.5: 15.00