HitPredict

Interactor 1: ADA15 (Q13444)
Disintegrin and metalloproteinase domain-containing protein 15 (ADAM 15) (EC 3.4.24.-) (Metalloprotease RGD disintegrin protein) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15) (MDC-15) (Metargidin)
Gene: ADAM15

Interactor 2: SH3R3 (Q8TEJ3)
E3 ubiquitin-protein ligase SH3RF3 (EC 2.3.2.27) (Plenty of SH3s 2) (SH3 domain-containing RING finger protein 3) (SH3 multiple domains protein 4)
Gene: SH3RF3

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.50	0.512

Property	Details
Experiments	16374509
Identification Methods	pull down, filter binding
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 863 Hs			1 882
+	Hs
		1105812 ADA15_HUMAN (1-863): 0: 559: 100.00		SH3R1_HUMAN (46-882): 3.14e-91: 310: 41.06
+	Hs
		1105832 ADA15_HUMAN (1-863): 0: 559: 100.00		RIM3A_HUMAN (56-882): 1.16e-35: 148: 11.39
+	Mm
		1222257 ADAM9_MOUSE (1-832): 1.31e-177: 535: 31.59		PACN3_MOUSE (10-253): 7.76e-39: 152: 16.97
+	Hs
		1105800 ADA15_HUMAN (1-863): 0: 559: 100.00		ARHG6_HUMAN (774-882): 4e-19: 94.9: 23.85
+	Hs
		1105805 ADA15_HUMAN (1-863): 0: 559: 100.00		SPD2A_HUMAN (92-881): 2.78e-18: 92.6: 11.06
+	Hs
		987612 ADA15_HUMAN (1-863): 0: 559: 100.00		GRB2_HUMAN (193-254): 4.35e-20: 91.8: 30.65
+	Hs
		1105799 ADA15_HUMAN (1-863): 0: 559: 100.00		ARHG7_HUMAN (812-882): 2.73e-15: 82.6: 28.17
+	Hs
		1105803 ADA15_HUMAN (1-863): 0: 559: 100.00		ITSN1_HUMAN (520-882): 4.78e-12: 72.2: 6.89
+	Hs
		1105835 ADA15_HUMAN (1-863): 0: 559: 100.00		PACN3_HUMAN (519-880): 2.04e-12: 72.2: 11.11
+	Mm
		1221222 ADA12_MOUSE (37-860): 4.03e-177: 536: 35.19		GRB2_MOUSE (191-254): 3.4e-20: 92.2: 29.69
+	Hs
		1105824 ADA15_HUMAN (1-863): 0: 559: 100.00		SH3G2_HUMAN (197-256): 3.96e-11: 67.4: 46.67
+	Hs
		1105825 ADA15_HUMAN (1-863): 0: 559: 100.00		SRBS1_HUMAN (129-250): 3.72e-09: 62.9: 17.74
+	Hs
		320240 ADA15_HUMAN (1-863): 0: 559: 100.00		SRBS2_HUMAN (121-251): 9.78e-09: 61.3: 15.04
+	Hs
		209886 ADA12_HUMAN (42-856): 4.89e-170: 518: 35.70		GRB2_HUMAN (193-254): 4.35e-20: 91.8: 30.65
+	Mm
		1222256 ADAM9_MOUSE (1-832): 1.31e-177: 535: 31.59		SH3G2_MOUSE (197-256): 2.92e-11: 68.2: 46.67
+	Hs
		1105792 ADAM9_HUMAN (31-815): 5.19e-172: 520: 31.31		PACN3_HUMAN (519-880): 2.04e-12: 72.2: 11.11
+	Hs
		209891 ADA12_HUMAN (42-856): 4.89e-170: 518: 35.70		ITSN1_HUMAN (520-882): 4.78e-12: 72.2: 6.89
+	Hs
		1105767 ADAM9_HUMAN (31-815): 5.19e-172: 520: 31.31		SH3G2_HUMAN (197-256): 3.96e-11: 67.4: 46.67
+	Hs
		320239 ADAM9_HUMAN (31-815): 5.19e-172: 520: 31.31		SRBS2_HUMAN (121-251): 9.78e-09: 61.3: 15.04
+	Hs
		209894 ADA12_HUMAN (42-856): 4.89e-170: 518: 35.70		SH319_HUMAN (319-880): 2.78e-09: 62.9: 14.01