HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: FILA2 (Q5D862)
Filaggrin-2 (FLG-2) (Intermediate filament-associated and psoriasis-susceptibility protein) (Ifapsoriasin)
Gene: FLG2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 2391
+	Hs
		1114868 CUL4A_HUMAN (4-745): 0: 770: 26.86		FILA2_HUMAN (1-2391): 0: 765: 100.00
+	Hs
		775533 CUL2_HUMAN (1-745): 0: 839: 100.00		NU214_HUMAN (231-1142): 1.63e-57: 224: 17.35
+	Hs
		161463 CUL3_HUMAN (1-745): 0: 763: 26.38		KMT2D_HUMAN (388-2260): 3.65e-79: 295: 7.20
+	Hs
		1115301 CUL4B_HUMAN (4-745): 0: 767: 27.79		RMXL3_HUMAN (1633-2390): 3.83e-62: 235: 10.55
+	Hs
		1112906 CUL2_HUMAN (1-745): 0: 839: 100.00		HORN_HUMAN (491-2391): 2.48e-36: 154: 24.26
+	Hs
		444974 CUL2_HUMAN (1-745): 0: 839: 100.00		S10A9_HUMAN (1-109): 6.69e-43: 154: 30.91
+	Hs
		682483 CUL2_HUMAN (1-745): 0: 839: 100.00		S100P_HUMAN (1-95): 4.71e-43: 154: 41.05
+	Hs
		775535 CUL4B_HUMAN (4-745): 0: 767: 27.79		NU214_HUMAN (231-1142): 1.63e-57: 224: 17.35
+	Hs
		471589 CUL3_HUMAN (1-745): 0: 763: 26.38		CO4A2_HUMAN (238-1713): 5.61e-57: 221: 10.34
+	Hs
		424192 CUL2_HUMAN (1-745): 0: 839: 100.00		S10A8_HUMAN (1-95): 7.66e-36: 133: 29.47
+	Hs
		635586 CUL2_HUMAN (1-745): 0: 839: 100.00		FILA_HUMAN (85-1521): 5.63e-26: 120: 15.64
+	Hs
		1114923 CUL4A_HUMAN (4-745): 0: 770: 26.86		HORN_HUMAN (491-2391): 2.48e-36: 154: 24.26
+	Hs
		1112924 CUL2_HUMAN (1-745): 0: 839: 100.00		ARI1B_HUMAN (746-2140): 4.64e-09: 64.3: 9.63
+	Hs
		438030 CUL3_HUMAN (1-745): 0: 763: 26.38		CO5A2_HUMAN (184-1260): 6.69e-31: 135: 12.18
+	Hs
		569040 CUL3_HUMAN (1-745): 0: 763: 26.38		COBA2_HUMAN (1916-2391): 1.8e-28: 128: 9.54
+	Hs
		384313 CUL3_HUMAN (1-745): 0: 763: 26.38		CO4A1_HUMAN (127-1366): 1.68e-26: 121: 11.23
+	Hs
		465961 CUL3_HUMAN (1-745): 0: 763: 26.38		CO1A2_HUMAN (2066-2390): 4.96e-21: 103: 8.28
+	Hs
		551738 CUL3_HUMAN (1-745): 0: 763: 26.38		COBA1_HUMAN (336-1328): 2.92e-20: 101: 10.28
+	Hs
		384253 CUL3_HUMAN (1-745): 0: 763: 26.38		CO2A1_HUMAN (2011-2391): 1.24e-19: 99: 9.49
+	Hs
		384151 CUL3_HUMAN (1-745): 0: 763: 26.38		CO1A1_HUMAN (2120-2391): 1.2e-10: 69.4: 9.56