HitPredict

Interactor 1: RGL3 (Q3UYI5)
Ral guanine nucleotide dissociation stimulator-like 3 (RalGDS-like 3) (RalGDS-related effector protein of M-Ras) (Ras pathway modulator) (RPM)
Gene: RGL3

Interactor 2: RASH (Q61411)
GTPase HRas (EC 3.6.5.2) (H-Ras-1) (Transforming protein p21) (c-H-ras) (p21ras) [Cleaved into: GTPase HRas, N-terminally processed]
Gene: Hras

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	10869344
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	RA~Ras, Ras~RasGEF, Ras~RasGEF_N
Common GO terms	GO:0005886 - plasma membrane GO:0007264 - small GTPase-mediated signal transduction GO:0007265 - Ras protein signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 709 Mm			1 189
+	Hs
		348971 RGL1_HUMAN (10-697): 0: 658: 36.02		RASN_HUMAN (1-188): 6.47e-88: 257: 85.64
+	Hs
		348697 RGL3_HUMAN (1-709): 0: 654: 78.26		RASN_HUMAN (1-188): 6.47e-88: 257: 85.64
+	Mm
		936775 RGL3_MOUSE (1-709): 0: 712: 100.00		RIT1_MOUSE (3-167): 4.88e-57: 180: 51.81
+	Hs
		349692 RGL1_HUMAN (10-697): 0: 658: 36.02		RASH_HUMAN (16-189): 5.68e-73: 219: 100.00
+	Hs
		349360 RGL3_HUMAN (1-709): 0: 654: 78.26		RASH_HUMAN (16-189): 5.68e-73: 219: 100.00
+	Hs
		897964 RGL1_HUMAN (10-697): 0: 658: 36.02		RAP1B_HUMAN (1-165): 2.18e-63: 195: 57.49
+	Hs
		919681 RGL1_HUMAN (10-697): 0: 658: 36.02		RAP1A_HUMAN (1-165): 3.2e-62: 192: 56.89
+	Hs
		1273185 RGL1_HUMAN (10-697): 0: 658: 36.02		RIT1_HUMAN (3-167): 1.65e-56: 179: 51.81
+	Hs
		905457 RGL1_HUMAN (10-697): 0: 658: 36.02		RRAS2_HUMAN (3-188): 6.39e-57: 179: 55.26
+	Hs
		1109718 RGL3_HUMAN (1-709): 0: 654: 78.26		RIT1_HUMAN (3-167): 1.65e-56: 179: 51.81
+	Hs
		905428 RGL3_HUMAN (1-709): 0: 654: 78.26		RRAS2_HUMAN (3-188): 6.39e-57: 179: 55.26
+	Hs
		350126 GNDS_HUMAN (12-709): 0: 572: 31.23		RASK_HUMAN (1-188): 2.04e-84: 248: 86.24
+	Hs
		171531 RGL2_HUMAN (12-702): 0: 556: 35.33		RASN_HUMAN (1-188): 6.47e-88: 257: 85.64
+	Mm
		976137 GNDS_MOUSE (12-709): 0: 583: 30.90		RASH_MOUSE (16-189): 5.68e-73: 219: 100.00
+	Hs
		349279 GNDS_HUMAN (12-709): 0: 572: 31.23		RASH_HUMAN (16-189): 5.68e-73: 219: 100.00
+	Hs
		171532 RGL2_HUMAN (12-702): 0: 556: 35.33		RASH_HUMAN (16-189): 5.68e-73: 219: 100.00
+	Hs
		897883 GNDS_HUMAN (12-709): 0: 572: 31.23		RAP1B_HUMAN (1-165): 2.18e-63: 195: 57.49
+	Hs
		919618 GNDS_HUMAN (12-709): 0: 572: 31.23		RAP1A_HUMAN (1-165): 3.2e-62: 192: 56.89
+	Hs
		1021726 GNDS_HUMAN (12-709): 0: 572: 31.23		RIT1_HUMAN (3-167): 1.65e-56: 179: 51.81
+	Hs
		905420 GNDS_HUMAN (12-709): 0: 572: 31.23		RRAS2_HUMAN (3-188): 6.39e-57: 179: 55.26