HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KBTB2 (Q8IY47)
Kelch repeat and BTB domain-containing protein 2 (BTB and kelch domain-containing protein 1)
Gene: KBTBD2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.93 1.00 0.966

The method score is based on:

Property Details
Experiments 27708159, 28514442, 33961781, 34878901, 35563538, 37495603, 21145461, 34591642
Identification Methods affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains BACK~Cullin, BTB~Cullin
Common GO terms GO:0005737 - cytoplasm
GO:0010467 - gene expression
GO:0031463 - Cul3-RING ubiquitin ligase complex
GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936 - protein K48-linked ubiquitination
and 1 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Last updated: 11Aug2025