HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: GMCL1 (Q96IK5)
Germ cell-less protein-like 1 (Spermatogenesis-associated protein 29)
Gene: GMCL1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.84	1.00	0.920

Property	Details
Experiments	25416956, 32296183, 21145461, 31515488, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, tandem affinity purification, two hybrid array, two hybrid prey pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 515
+	Hs
		1113277 CUL3_HUMAN (1-768): 0: 943: 100.00		Q53SE7_HUMAN (1-515): 0: 534: 100.00
+	Hs
		1114054 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL5_HUMAN (10-390): 5.95e-80: 266: 13.43
+	Hs
		1113634 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL7_HUMAN (97-417): 8e-81: 264: 14.20
+	Hs
		1114400 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL1_HUMAN (2-390): 5.96e-79: 263: 15.17
+	Hs
		1113454 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH24_HUMAN (89-358): 1.07e-79: 262: 20.88
+	Hs
		320822 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH18_HUMAN (73-351): 2.4e-79: 260: 18.12
+	Hs
		1113267 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH12_HUMAN (81-353): 1.19e-76: 253: 17.79
+	Hs
		1113453 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH17_HUMAN (22-345): 3.04e-75: 251: 17.27
+	Hs
		1113077 CUL3_HUMAN (1-768): 0: 943: 100.00		KEAP1_HUMAN (31-402): 2.24e-74: 248: 14.99
+	Hs
		1113862 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL6_HUMAN (59-358): 1.05e-71: 241: 19.47
+	Hs
		329059 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL2_HUMAN (54-345): 9.53e-72: 241: 17.07
+	Hs
		1114259 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH25_HUMAN (64-357): 2.44e-71: 240: 18.18
+	Hs
		1113399 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH10_HUMAN (73-342): 2.69e-69: 235: 20.80
+	Hs
		161296 CUL3_HUMAN (1-768): 0: 943: 100.00		ENC1_HUMAN (64-388): 1.27e-69: 235: 18.29
+	Hs
		1113681 CUL3_HUMAN (1-768): 0: 943: 100.00		Q8N4I8_HUMAN (67-346): 2.53e-72: 233: 17.79
+	Hs
		1114195 CUL3_HUMAN (1-768): 0: 943: 100.00		BTBD2_HUMAN (86-366): 7.82e-67: 226: 19.08
+	Hs
		1114255 CUL3_HUMAN (1-768): 0: 943: 100.00		BTBD1_HUMAN (86-366): 3.66e-66: 223: 18.39
+	Hs
		1113753 CUL3_HUMAN (1-768): 0: 943: 100.00		KBTB8_HUMAN (61-304): 1.04e-64: 222: 17.89
+	Hs
		1113639 CUL3_HUMAN (1-768): 0: 943: 100.00		KBTB2_HUMAN (74-290): 1.25e-63: 219: 21.10
+	Hs
		1113719 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH23_HUMAN (98-282): 2.11e-33: 135: 24.60