HitPredict

Interactor 1: CUL4B (Q13620)
Cullin-4B (CUL-4B)
Gene: CUL4B

Interactor 2: WDTC1 (Q8N5D0)
WD and tetratricopeptide repeats protein 1
Gene: WDTC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.720

Property	Details
Experiments	27113764, 31973889, 33961781, 28514442, unassigned3799
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0016567 - protein ubiquitination GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Hs			1 677
+	Mm
		58997 CUL4B_MOUSE (36-913): 0: 1109: 97.28		WDTC1_MOUSE (1-677): 7.93e-133: 408: 95.72
+	Mm
		1189315 CUL4A_MOUSE (161-913): 0: 968: 81.96		WDTC1_MOUSE (1-677): 7.93e-133: 408: 95.72
+	Hs
		1115237 CUL4B_HUMAN (1-913): 0: 1185: 100.00		DCAF6_HUMAN (479-669): 1.62e-40: 161: 29.85
+	Hs
		161718 CUL4B_HUMAN (1-913): 0: 1185: 100.00		APAF_HUMAN (226-656): 2.16e-37: 152: 8.72
+	Hs
		505648 CUL4B_HUMAN (1-913): 0: 1185: 100.00		DC8L2_HUMAN (237-677): 4.82e-36: 146: 16.74
+	Hs
		1085651 CUL4B_HUMAN (1-913): 0: 1185: 100.00		TBL3_HUMAN (11-323): 3.43e-32: 135: 11.37
+	Hs
		1115246 CUL4B_HUMAN (1-913): 0: 1185: 100.00		DCAF8_HUMAN (511-677): 3.02e-31: 131: 26.29
+	Hs
		261407 CUL4B_HUMAN (1-913): 0: 1185: 100.00		TBL1X_HUMAN (84-378): 2.16e-27: 119: 10.65
+	Hs
		1115406 CUL4B_HUMAN (1-913): 0: 1185: 100.00		TBL1R_HUMAN (75-403): 1.69e-26: 116: 10.44
+	Hs
		1115313 CUL4B_HUMAN (1-913): 0: 1185: 100.00		POC1B_HUMAN (448-670): 8.82e-24: 107: 8.73
+	Hs
		845298 CUL4B_HUMAN (1-913): 0: 1185: 100.00		LIS1_HUMAN (494-670): 2.41e-24: 107: 9.89
+	Hs
		1115353 CUL4B_HUMAN (1-913): 0: 1185: 100.00		SNR40_HUMAN (5-118): 1.48e-18: 89.9: 21.67
+	Hs
		964929 CUL4B_HUMAN (1-913): 0: 1185: 100.00		WDR5_HUMAN (527-670): 2.13e-18: 89.1: 12.75
+	Hs
		1115361 CUL4B_HUMAN (1-913): 0: 1185: 100.00		DCAF5_HUMAN (526-623): 2.41e-10: 66: 31.25
+	Hs
		1115283 CUL4B_HUMAN (1-913): 0: 1185: 100.00		WDR5B_HUMAN (551-649): 1.15e-09: 62.5: 17.00
+	Hs
		505647 CUL4A_HUMAN (161-913): 0: 957: 81.83		DC8L2_HUMAN (237-677): 4.82e-36: 146: 16.74
+	Mm
		1189318 CUL4A_MOUSE (161-913): 0: 968: 81.96		DCAF8_MOUSE (511-677): 3.8e-31: 130: 29.15
+	Hs
		845297 CUL4A_HUMAN (161-913): 0: 957: 81.83		LIS1_HUMAN (494-670): 2.41e-24: 107: 9.89
+	Hs
		921886 CUL4A_HUMAN (161-913): 0: 957: 81.83		COPA_HUMAN (5-202): 3.65e-20: 97.9: 14.14
+	Hs
		964928 CUL4A_HUMAN (161-913): 0: 957: 81.83		WDR5_HUMAN (527-670): 2.13e-18: 89.1: 12.75