HitPredict

Interactor 1: CUL4B (Q13620)
Cullin-4B (CUL-4B)
Gene: CUL4B

Interactor 2: AMRA1 (Q9C0C7)
Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3)
Gene: AMBRA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.93	0.60	0.749

Property	Details
Experiments	25499913, 30166453, 31973889, 33854239, 16949367, 31155351, 21145461, unassigned3799
Identification Methods	enzymatic study, affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000209 - protein polyubiquitination GO:0005634 - nucleus GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0080008 - Cul4-RING E3 ubiquitin ligase complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 913 Hs			1 1298
+	Hs
		1115044 CUL4A_HUMAN (161-913): 0: 957: 81.83		AMRA1_HUMAN (1-1298): 0: 1596: 100.00
+	Hs
		964929 CUL4B_HUMAN (1-913): 0: 1185: 100.00		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	Hs
		1115361 CUL4B_HUMAN (1-913): 0: 1185: 100.00		DCAF5_HUMAN (13-774): 1.19e-70: 258: 14.37
+	Hs
		1115283 CUL4B_HUMAN (1-913): 0: 1185: 100.00		WDR5B_HUMAN (4-207): 3.21e-55: 197: 14.68
+	Hs
		1115353 CUL4B_HUMAN (1-913): 0: 1185: 100.00		SNR40_HUMAN (45-334): 1.8e-54: 196: 12.04
+	Hs
		845298 CUL4B_HUMAN (1-913): 0: 1185: 100.00		LIS1_HUMAN (123-363): 2.02e-35: 142: 12.30
+	Hs
		1115343 CUL4B_HUMAN (1-913): 0: 1185: 100.00		FBXW7_HUMAN (164-314): 4.21e-18: 92.2: 10.53
+	Hs
		161718 CUL4B_HUMAN (1-913): 0: 1185: 100.00		APAF_HUMAN (33-203): 4.66e-16: 86.3: 19.23
+	Hs
		1115313 CUL4B_HUMAN (1-913): 0: 1185: 100.00		POC1B_HUMAN (1-83): 2.36e-16: 85.7: 16.28
+	Hs
		261407 CUL4B_HUMAN (1-913): 0: 1185: 100.00		TBL1X_HUMAN (28-159): 4.55e-15: 82.1: 20.14
+	Hs
		1115406 CUL4B_HUMAN (1-913): 0: 1185: 100.00		TBL1R_HUMAN (28-201): 1.6e-14: 80.1: 17.98
+	Hs
		964928 CUL4A_HUMAN (161-913): 0: 957: 81.83		WDR5_HUMAN (3-297): 1.09e-86: 287: 18.39
+	Hs
		1115000 CUL4A_HUMAN (161-913): 0: 957: 81.83		DCAF5_HUMAN (13-774): 1.19e-70: 258: 14.37
+	At
		99584 CUL4_ARATH (147-913): 0: 920: 55.73		KTN82_ARATH (10-772): 7.07e-67: 249: 11.59
+	Hs
		1114921 CUL4A_HUMAN (161-913): 0: 957: 81.83		WDR5B_HUMAN (4-207): 3.21e-55: 197: 14.68
+	Hs
		1114994 CUL4A_HUMAN (161-913): 0: 957: 81.83		SNR40_HUMAN (45-334): 1.8e-54: 196: 12.04
+	Hs
		845297 CUL4A_HUMAN (161-913): 0: 957: 81.83		LIS1_HUMAN (123-363): 2.02e-35: 142: 12.30
+	Hs
		1114950 CUL4A_HUMAN (161-913): 0: 957: 81.83		POC1B_HUMAN (1-83): 2.36e-16: 85.7: 16.28
+	Hs
		1115179 CUL4A_HUMAN (161-913): 0: 957: 81.83		WSB1_HUMAN (57-256): 4.54e-15: 81.3: 13.51
+	Hs
		1115101 CUL4A_HUMAN (161-913): 0: 957: 81.83		WSB2_HUMAN (41-201): 1.67e-13: 75.9: 23.67