HitPredict

Interactor 1: SHC1 (Q5M824)
SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1)
Gene: SHC1

Interactor 2: Q9QX70 (Q9QX70)
Receptor protein-tyrosine kinase (EC 2.7.10.1)
Gene: Egfr

Species: Rattus norvegicus

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.56 1.00 0.754

The method score is based on:

Property Details
Experiments 9722539, 12218049
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~SH2
Common GO terms GO:0005886 - plasma membrane
GO:0007173 - epidermal growth factor receptor signaling pathway
GO:0008284 - positive regulation of cell population proliferation
GO:0010008 - endosome membrane
GO:0014070 - response to organic cyclic compound
and 13 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024