HitPredict

Interactor 1: LRRK2 (Q5S007)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)
Gene: LRRK2

Interactor 2: RPAP3 (Q9H6T3)
RNA polymerase II-associated protein 3
Gene: RPAP3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	24510904
Identification Methods	pull down, protein array
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 2527 Hs			1 665
+	Hs
		174950 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		OGT1_HUMAN (202-656): 7.67e-29: 125: 11.89
+	Hs
		684799 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		STIP1_HUMAN (100-594): 6.38e-20: 95.9: 14.23
+	Hs
		66551 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		A8K690_HUMAN (100-594): 1.35e-19: 94.7: 14.23
+	Hs
		297066 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		TOM70_HUMAN (36-379): 1.61e-15: 82.2: 16.52
+	Hs
		1130486 LRRK2_HUMAN (1-2527): 0: 3008: 99.72		DNJC7_HUMAN (42-289): 2.69e-15: 81.2: 16.11
+	Hs
		1332525 MFHA1_HUMAN (838-1119): 1.5e-30: 134: 16.95		RPAP3_HUMAN (1-665): 1.27e-121: 378: 100.00
+	Hs
		684476 CSK_HUMAN (1722-2140): 2.25e-102: 339: 20.74		STIP1_HUMAN (100-594): 6.38e-20: 95.9: 14.23
+	Hs
		175307 SHOC2_HUMAN (944-1353): 1.23e-60: 222: 22.27		OGT1_HUMAN (202-656): 7.67e-29: 125: 11.89
+	Hs
		858630 LRRK1_HUMAN (771-1194): 2.3e-35: 151: 16.38		PPP5_HUMAN (131-251): 3.46e-14: 77.4: 32.23
+	Mm
		1141210 M3K7_MOUSE (1869-2132): 1.06e-22: 107: 28.83		PPP5_MOUSE (131-251): 3.54e-15: 80.5: 33.88
+	Hs
		201277 M3K7_HUMAN (1869-2132): 8.36e-23: 107: 28.83		PPP5_HUMAN (131-251): 3.46e-14: 77.4: 32.23