HitPredict

Interactor 1: M3K7 (Q62073)
Mitogen-activated protein kinase kinase kinase 7 (EC 2.7.11.25) (Transforming growth factor-beta-activated kinase 1) (TGF-beta-activated kinase 1)
Gene: Map3k7

Interactor 2: SMAD2 (Q62432)
Mothers against decapentaplegic homolog 2 (MAD homolog 2) (Mothers against DPP homolog 2) (Mad-related protein 2) (mMad2) (SMAD family member 2) (SMAD 2) (Smad2)
Gene: SMAD2

Species: Mus musculus

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15911626
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0007179 - transforming growth factor beta receptor signaling pathway GO:0010629 - negative regulation of gene expression GO:0031625 - ubiquitin protein ligase binding GO:0140297 - DNA-binding transcription factor binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 579 Mm			1 467
+	Mm
		1143261 M3K7_MOUSE (1-579): 0: 556: 100.00		SMAD3_MOUSE (1-467): 0: 621: 83.94
+	Mm
		1143273 M3K7_MOUSE (1-579): 0: 556: 100.00		SMAD9_MOUSE (1-467): 0: 584: 58.40
+	Mm
		956496 M3K7_MOUSE (1-579): 0: 556: 100.00		SMAD5_MOUSE (1-467): 0: 576: 55.25
+	Mm
		936609 M3K7_MOUSE (1-579): 0: 556: 100.00		SMAD1_MOUSE (1-467): 0: 575: 55.42
+	Mm
		956544 M3K7_MOUSE (1-579): 0: 556: 100.00		SMAD4_MOUSE (11-456): 5.89e-144: 425: 31.63
+	Hs
		201132 M3K7_HUMAN (1-579): 0: 540: 94.88		SMAD6_HUMAN (38-445): 5.23e-113: 343: 26.15
+	Hs
		167311 M3K7_HUMAN (1-579): 0: 540: 94.88		SMAD7_HUMAN (13-443): 6.37e-110: 333: 25.29