HitPredict

Interactor 1: Q29QQ9 (Q29QQ9)
Ribosomal RNA-processing protein 42
Gene: Rrp42

Interactor 2: Q9VC93 (Q9VC93)
Exosome complex exonuclease RRP44 (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44)
Gene: Dis3

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	19220816, 20421210, 22036573, 38944040
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	OB_Dis3~RNase_PH, RNB~RNase_PH, OB_Dis3~RNase_PH_C
Common GO terms	GO:0000176 - nuclear exosome (RNase complex) GO:0000177 - cytoplasmic exosome (RNase complex) GO:0000178 - exosome (RNase complex) GO:0005652 - nuclear lamina GO:0016075 - rRNA catabolic process
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 296 Dm			1 982
+	Dm
		1345951 Q8T4A9_DROME (3-286): 2.9e-75: 237: 20.98		Q9VC93_DROME (1-972): 0: 1228: 100.00
+	Hs
		1384052 EXOS8_HUMAN (1-283): 8.64e-87: 262: 25.35		RRP44_HUMAN (1-965): 0: 1170: 54.78
+	Hs
		1137688 EXOS7_HUMAN (1-295): 1.18e-85: 260: 48.14		RRP44_HUMAN (1-965): 0: 1170: 54.78
+	Hs
		1054527 EXOS9_HUMAN (1-286): 6.55e-71: 227: 25.35		RRP44_HUMAN (1-965): 0: 1170: 54.78
+	Dm
		1470084 Q9VK19_DROME (19-280): 9.13e-50: 166: 17.80		Q9VC93_DROME (1-972): 0: 1228: 100.00
+	Hs
		1446209 EXOS4_HUMAN (14-285): 1.14e-53: 176: 17.03		RRP44_HUMAN (1-965): 0: 1170: 54.78
+	Sp
		268494 RRP45_SCHPO (2-287): 3.86e-75: 233: 21.88		DIS3_SCHPO (3-945): 0: 1019: 42.65
+	Hs
		1353555 EXOS8_HUMAN (1-283): 8.64e-87: 262: 25.35		DI3L1_HUMAN (1-958): 0: 974: 32.08
+	Hs
		1137646 EXOS7_HUMAN (1-295): 1.18e-85: 260: 48.14		DI3L1_HUMAN (1-958): 0: 974: 32.08
+	Sp
		789321 RRP43_SCHPO (3-265): 8.07e-68: 213: 25.10		DIS3_SCHPO (3-945): 0: 1019: 42.65
+	Sc
		1051718 RRP45_YEAST (2-288): 1.09e-71: 225: 19.87		RRP44_YEAST (2-946): 0: 992: 41.26
+	At
		101062 RRP41_ARATH (20-288): 2.04e-55: 181: 16.54		F4INI6_ARATH (1-945): 0: 1026: 41.70
+	Hs
		1054489 EXOS9_HUMAN (1-286): 6.55e-71: 227: 25.35		DI3L1_HUMAN (1-958): 0: 974: 32.08
+	Sp
		206876 RRP41_SCHPO (12-282): 5.17e-48: 162: 17.52		DIS3_SCHPO (3-945): 0: 1019: 42.65
+	Sp
		238043 RRP42_SCHPO (4-287): 2.67e-41: 146: 25.16		DIS3_SCHPO (3-945): 0: 1019: 42.65
+	Hs
		1353559 EXOS4_HUMAN (14-285): 1.14e-53: 176: 17.03		DI3L1_HUMAN (1-958): 0: 974: 32.08
+	Sc
		1061961 RRP42_YEAST (4-231): 2.34e-42: 148: 23.28		RRP44_YEAST (2-946): 0: 992: 41.26
+	Sc
		863145 RRP41_YEAST (20-284): 1e-23: 98.7: 16.67		RRP44_YEAST (2-946): 0: 992: 41.26
+	Pf
		1302559 Q8ID62_PLAF7 (4-292): 5.66e-70: 225: 19.24		Q8IDB6_PLAF7 (4-936): 0: 809: 27.45