Protein: DI3L1
DIS3-like exonuclease 1 (EC 3.1.13.1)

Gene: DI3L1, DIS3L
Organism: Homo sapiens
Interactions: 46
UniProt ID: Q8TF46

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0003723 - RNA binding
GO:0005813 - centrosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1353555

EXOS8
Exosome complex component RRP43

6

19

Small-scale

0.952

High

1353559

EXOS4
Exosome complex component RRP41

5

19

Small-scale

0.932

High

1137646

EXOS7
Exosome complex component RRP42

5

19

Small-scale

0.930

High

1353560

EXOS5
Exosome complex component RRP46

5

20

Small-scale

0.930

High

1054489

EXOS9
Exosome complex component RRP45

3

20

Small-scale

0.867

High

1209102

EXOS6
Exosome complex component MTR3

3

20

Small-scale

0.861

High

1353561

EXOS3
Exosome complex component RRP40

8

4

Small-scale

0.754

High

1353563

EXOS1
Exosome complex component CSL4

5

10

Small-scale

0.723

High

1118307

EXOS2
Exosome complex component RRP4

5

5

Small-scale

0.722

High

1353564

HBS1L
HBS1-like protein

5

1

Small-scale

0.718

High

1032203

EXOSX
Exosome complex component 10

3

5

Small-scale

0.667

High

1251392

GGYF2
GRB10-interacting GYF protein 2

3

1

Small-scale

0.667

High

252126

IF4E2
Eukaryotic translation initiation factor 4E type 2

3

2

Small-scale

0.650

High

1353557

MPH6
M-phase phosphoprotein 6

3

1

High-throughput

0.650

High

346104

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

1

High-throughput

0.584

High

838764

MTREX
Exosome RNA helicase MTR4

2

8

Small-scale

0.584

High

472918

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.536

High

591750

H2AX
Histone H2AX

1

3

High-throughput

0.536

High

1119069

C1D
Nuclear nucleic acid-binding protein C1D

1

1

High-throughput

0.536

High

1178854

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.513

High

1288541

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

Small-scale

0.513

High

943600

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

1

High-throughput

0.494

High

1279661

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

1253859

SRCAP
Helicase SRCAP

1

3

High-throughput

0.489

High

124947

GTPB1
GTP-binding protein 1

1

3

High-throughput

0.479

High

173128

XPO1
Exportin-1

1

2

High-throughput

0.479

High

1353565

RBM7
RNA-binding protein 7

1

4

High-throughput

0.479

High

914955

THOP1
Thimet oligopeptidase

1

0

High-throughput

0.458

High

1132026

STAT4
Signal transducer and activator of transcription 4

1

0

High-throughput

0.458

High

1161796

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.458

High

1240246

ZCHC8
Zinc finger CCHC domain-containing protein 8

1

0

High-throughput

0.458

High

1295508

MIB1
E3 ubiquitin-protein ligase MIB1

1

0

High-throughput

0.458

High

1350385

BICD2
Protein bicaudal D homolog 2

1

0

High-throughput

0.458

High

1353554

CNOT9
CCR4-NOT transcription complex subunit 9

1

0

High-throughput

0.458

High

1353556

EYA3
Protein phosphatase EYA3

1

0

High-throughput

0.458

High

1353562

BRPF3
Bromodomain and PHD finger-containing protein 3

1

0

High-throughput

0.458

High

1217893

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

1

High-throughput

0.439

High

1248891

LCN15
Lipocalin-15

3

0

High-throughput

0.347

High

1216612

LIN9
Protein lin-9 homolog

2

0

High-throughput

0.328

High

1353558

IQCN
IQ domain-containing protein N

2

0

High-throughput

0.328

High

1123522

BTG3
Protein BTG3

1

0

High-throughput

0.282

High

553022

PIP
Prolactin-inducible protein

1

0

High-throughput

0.279

Low

1257086

PAXI1
PAX-interacting protein 1

1

0

High-throughput

0.251

Low

553846

KCRU
Creatine kinase U-type, mitochondrial

1

0

High-throughput

0.249

Low

1336197

RN214
RING finger protein 214

1

0

High-throughput

0.249

Low

947028

DSCR9
Down syndrome critical region protein 9

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025