Protein: EXOS9
Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75)

Gene: EXOS9, EXOSC9
Organism: Homo sapiens
Interactions: 135
UniProt ID: Q06265

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000176 - nuclear exosome (RNase complex)
GO:0000177 - cytoplasmic exosome (RNase complex)
GO:0000178 - exosome (RNase complex)
GO:0000228 - nuclear chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1054512

EXOS4
Exosome complex component RRP41

11

19

Small-scale

0.980

High

1054464

EXOS7
Exosome complex component RRP42

7

18

Small-scale

0.963

High

1054460

EXOS2
Exosome complex component RRP4

7

20

Small-scale

0.956

High

1054515

EXOS3
Exosome complex component RRP40

6

13

Small-scale

0.953

High

1054496

EXOS8
Exosome complex component RRP43

5

18

High-throughput

0.927

High

1054528

EXOS1
Exosome complex component CSL4

4

20

High-throughput

0.903

High

1054514

EXOS5
Exosome complex component RRP46

3

19

High-throughput

0.871

High

1054489

DI3L1
DIS3-like exonuclease 1

3

20

Small-scale

0.867

High

1054468

EXOS6
Exosome complex component MTR3

2

17

High-throughput

0.789

High

1032150

EXOSX
Exosome complex component 10

5

13

Small-scale

0.706

High

1054527

RRP44
Exosome complex exonuclease RRP44

1

20

Small-scale

0.691

High

1054500

MPH6
M-phase phosphoprotein 6

4

7

Small-scale

0.689

High

1054461

C1D
Nuclear nucleic acid-binding protein C1D

3

3

High-throughput

0.675

High

1054530

HBS1L
HBS1-like protein

3

4

Small-scale

0.660

High

1054454

EXOS9
Exosome complex component RRP45

1

17

High-throughput

0.618

High

140886

NOP56
Nucleolar protein 56

2

7

High-throughput

0.611

High

1054531

RBM7
RNA-binding protein 7

2

9

High-throughput

0.611

High

272102

OBSL1
Obscurin-like protein 1

2

2

High-throughput

0.584

High

1054516

ANLN
Anillin

2

3

High-throughput

0.584

High

993516

UBC9
SUMO-conjugating enzyme UBC9

2

0

High-throughput

0.582

High

964240

SUMO2
Small ubiquitin-related modifier 2

2

0

High-throughput

0.577

High

395973

ESR1
Estrogen receptor

2

8

High-throughput

0.571

High

854010

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.536

High

859243

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

884072

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.536

High

969809

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

1054463

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

8

High-throughput

0.536

High

1054480

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.536

High

1054490

PHF10
PHD finger protein 10

1

4

High-throughput

0.536

High

1054491

PSPC1
Paraspeckle component 1

1

5

High-throughput

0.536

High

1054505

ZN106
Zinc finger protein 106

1

5

High-throughput

0.536

High

1054526

DRG1
Developmentally-regulated GTP-binding protein 1

1

3

High-throughput

0.536

High

997667

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.527

High

540847

ERG
Transcriptional regulator ERG

1

0

High-throughput

0.518

High

366171

HPT
Haptoglobin

1

0

High-throughput

0.513

High

687979

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.513

High

712190

TKT
Transketolase

1

0

High-throughput

0.513

High

1054458

CUL3
Cullin-3

1

0

High-throughput

0.513

High

1054462

SCRB2
Lysosome membrane protein 2

1

0

High-throughput

0.513

High

1054469

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

0

High-throughput

0.513

High

1054470

DAB2P
Disabled homolog 2-interacting protein

1

0

High-throughput

0.513

High

1054473

F111B
Serine protease FAM111B

1

0

High-throughput

0.513

High

1054495

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

1054522

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

1054476

SETX
Probable helicase senataxin

1

1

Small-scale

0.508

High

1054506

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.508

High

1054481

ZDH17
Palmitoyltransferase ZDHHC17

1

3

High-throughput

0.494

High

1054485

PARP8
Protein mono-ADP-ribosyltransferase PARP8

1

1

High-throughput

0.489

High

129002

MEN1
Menin

1

3

High-throughput

0.479

High

157270

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

241478

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

252051

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

3

High-throughput

0.479

High

315495

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

317564

SLIT2
Slit homolog 2 protein

1

2

High-throughput

0.479

High

319698

UFL1
E3 UFM1-protein ligase 1

1

2

High-throughput

0.479

High

330889

KI20A
Kinesin-like protein KIF20A

1

1

High-throughput

0.479

High

335103

ARI2
E3 ubiquitin-protein ligase ARIH2

1

3

High-throughput

0.479

High

371841

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

400700

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

413686

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

446937

NPM
Nucleophosmin

1

1

High-throughput

0.479

High

468293

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.479

High

472670

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

8

High-throughput

0.479

High

588531

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

620315

NUCL
Nucleolin

1

3

High-throughput

0.479

High

695280

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

714057

PML
Protein PML

1

2

High-throughput

0.479

High

768021

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

838703

MTREX
Exosome RNA helicase MTR4

1

16

High-throughput

0.479

High

867063

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.479

High

872239

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

908604

LUM
Lumican

1

2

High-throughput

0.479

High

914940

THOP1
Thimet oligopeptidase

1

3

High-throughput

0.479

High

937724

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.479

High

970383

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

980715

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

High-throughput

0.479

High

994487

YBOX1
Y-box-binding protein 1

1

5

Small-scale

0.479

High

998241

H31
Histone H3.1

1

1

High-throughput

0.479

High

1054455

NFX1
Transcriptional repressor NF-X1

1

3

High-throughput

0.479

High

1054456

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

1054465

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.479

High

1054466

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.479

High

1054467

E2F4
Transcription factor E2F4

1

1

High-throughput

0.479

High

1054471

IFIX
Pyrin and HIN domain-containing protein 1

1

5

High-throughput

0.479

High

1054472

ZCHC8
Zinc finger CCHC domain-containing protein 8

1

3

High-throughput

0.479

High

1054474

GGYF2
GRB10-interacting GYF protein 2

1

3

High-throughput

0.479

High

1054475

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

1054477

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

1054478

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

1

Small-scale

0.479

High

1054479

ZCH18
Zinc finger CCCH domain-containing protein 18

1

5

High-throughput

0.479

High

1054483

AHI1
Jouberin

1

8

Small-scale

0.479

High

1054484

LRC47
Leucine-rich repeat-containing protein 47

1

2

High-throughput

0.479

High

1054486

FBXW8
F-box/WD repeat-containing protein 8

1

8

High-throughput

0.479

High

1054487

SIR6
NAD-dependent protein deacylase sirtuin-6

1

2

High-throughput

0.479

High

1054488

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

3

High-throughput

0.479

High

1054492

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

1054493

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

1054494

KAT6A
Histone acetyltransferase KAT6A

1

4

High-throughput

0.479

High

1054497

DDRGK
DDRGK domain-containing protein 1

1

3

High-throughput

0.479

High

1054498

RSRC1
Serine/Arginine-related protein 53

1

2

High-throughput

0.479

High

1054501

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

1054503

AICDA
Single-stranded DNA cytosine deaminase

1

3

Small-scale

0.479

High

1054509

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.479

High

1054510

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

3

High-throughput

0.479

High

1054513

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.479

High

1054517

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

1054520

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

4

High-throughput

0.479

High

1054521

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1054523

XPO7
Exportin-7

1

2

High-throughput

0.479

High

1054525

FZR1
Fizzy-related protein homolog

1

9

High-throughput

0.479

High

463475

LYN
Tyrosine-protein kinase Lyn

1

0

High-throughput

0.458

High

558064

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

697086

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

711630

3MG
DNA-3-methyladenine glycosylase

1

0

Small-scale

0.458

High

984727

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

1054457

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1054482

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1054502

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

0

High-throughput

0.458

High

1054507

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

1054518

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1054529

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

1054511

CHM1A
Charged multivesicular body protein 1a

1

1

High-throughput

0.457

High

1054519

CHMP5
Charged multivesicular body protein 5

1

1

High-throughput

0.457

High

327961

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

2

High-throughput

0.445

High

429768

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

756161

MCM7
DNA replication licensing factor MCM7

1

1

Small-scale

0.445

High

1054504

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

2

High-throughput

0.445

High

1054508

LN28A
Protein lin-28 homolog A

1

5

High-throughput

0.445

High

1054459

DX39B
Spliceosome RNA helicase DDX39B

1

0

Small-scale

0.438

High

411790

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

1049141

RON
Macrophage-stimulating protein receptor

1

3

High-throughput

0.437

High

1054524

HECD1
E3 ubiquitin-protein ligase HECTD1

1

8

High-throughput

0.437

High

116287

H3BNT4
M-phase phosphoprotein 6

1

7

High-throughput

0.407

High

1054499

S35E1
Solute carrier family 35 member E1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025