HitPredict

Interactor 1: CBLB (Q3TTA7)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Interactor 2: ARHG7 (Q9ES28)
Rho guanine nucleotide exchange factor 7 (Beta-Pix) (PAK-interacting exchange factor beta) (p85SPR)
Gene: Arhgef7

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	16892055
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0035556 - intracellular signal transduction GO:0098794 - postsynapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 982 Mm			1 862
+	Hs
		1097934 CBLB_HUMAN (1-982): 0: 923: 94.41		ARHG7_HUMAN (1-781): 0: 600: 90.77
+	Hs
		913646 CBLB_HUMAN (1-982): 0: 923: 94.41		VAV2_HUMAN (1-742): 3.04e-123: 395: 17.83
+	Mm
		86323 B9EKI5_MOUSE (1-982): 0: 922: 95.21		VAV2_MOUSE (1-742): 7.39e-122: 391: 18.21
+	Hs
		651322 CBL_HUMAN (25-972): 0: 709: 47.13		ARHG7_HUMAN (1-781): 0: 600: 90.77
+	Hs
		1097960 CBLB_HUMAN (1-982): 0: 923: 94.41		VAV3_HUMAN (1-665): 2.99e-112: 365: 17.58
+	Hs
		584532 CBLB_HUMAN (1-982): 0: 923: 94.41		VAV_HUMAN (1-666): 1.69e-105: 347: 17.37
+	Hs
		651332 CBL_HUMAN (25-972): 0: 709: 47.13		ARHG6_HUMAN (1-861): 1.38e-174: 525: 51.73
+	Hs
		1097936 CBLB_HUMAN (1-982): 0: 923: 94.41		ITSN1_HUMAN (107-558): 2.38e-78: 280: 18.71
+	Hs
		1097958 CBLB_HUMAN (1-982): 0: 923: 94.41		ITSN2_HUMAN (153-558): 3.79e-78: 279: 19.27
+	Hs
		651233 CBL_HUMAN (25-972): 0: 709: 47.13		VAV2_HUMAN (1-742): 3.04e-123: 395: 17.83
+	Hs
		584472 CBL_HUMAN (25-972): 0: 709: 47.13		VAV_HUMAN (1-666): 1.69e-105: 347: 17.37
+	Mm
		1189601 CBLB_MOUSE (1-982): 0: 942: 100.00		ITSN2_MOUSE (108-248): 7.88e-12: 71.4: 26.57
+	Hs
		539943 CBL_HUMAN (25-972): 0: 709: 47.13		BCR_HUMAN (90-862): 1.19e-84: 297: 13.23
+	Hs
		651340 CBL_HUMAN (25-972): 0: 709: 47.13		ITSN1_HUMAN (107-558): 2.38e-78: 280: 18.71
+	Hs
		651445 CBL_HUMAN (25-972): 0: 709: 47.13		ITSN2_HUMAN (153-558): 3.79e-78: 279: 19.27
+	Mm
		651587 CBL_MOUSE (25-972): 0: 701: 46.64		ITSN1_MOUSE (107-558): 3.09e-76: 273: 19.13
+	Hs
		1154195 CBLC_HUMAN (29-492): 0: 601: 43.58		ITSN1_HUMAN (107-558): 2.38e-78: 280: 18.71
+	Hs
		1453443 CBLC_HUMAN (29-492): 0: 601: 43.58		ITSN2_HUMAN (153-558): 3.79e-78: 279: 19.27
+	Mm
		651588 CBL_MOUSE (25-972): 0: 701: 46.64		ITSN2_MOUSE (108-248): 7.88e-12: 71.4: 26.57
+	Ce
		145093 UNC89_CAEEL (375-699): 3.13e-14: 80.1: 13.61		VAV_CAEEL (2-655): 2e-90: 309: 16.90