HitPredict

Interactor 1: MFN1 (Q8IWA4)
Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1)
Gene: MFN1

Interactor 2: MFN1 (Q8IWA4)
Mitofusin-1 (EC 3.6.5.-) (Fzo homolog) (Transmembrane GTPase MFN1)
Gene: MFN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.64 1.00 0.802

The method score is based on:

Property Details
Experiments 27713096, 29483649
Identification Methods affinity chromatography technology, x-ray crystallography, fluorescent resonance energy transfer, molecular sieving
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Dynamin_N~Dynamin_N, Dynamin_N~Fzo_mitofusin, Fzo_mitofusin~Fzo_mitofusin
Common GO terms GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0008053 - mitochondrial fusion
and 5 others

more...
Homologous interactions 3

Homologous interactions

Color coding for hit scores

1 741
Hs

1 741
+ Mm
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024