Protein: D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial (EC 1.1.99.39)

Gene: D2HDH, D2HGDH
Organism: Homo sapiens
Interactions: 140
UniProt ID: Q8N465

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006103 - 2-oxoglutarate metabolic process
GO:0006108 - malate metabolic process
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

602122

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

2

2

High-throughput

0.621

High

100144

F6VUV4
Dehydrogenase/reductase 4 like 2

3

2

High-throughput

0.585

High

1078271

RAB30
Ras-related protein Rab-30

2

1

High-throughput

0.574

High

499925

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.536

High

1038281

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

2

High-throughput

0.536

High

1156153

GPAT2
Glycerol-3-phosphate acyltransferase 2, mitochondrial

1

1

High-throughput

0.536

High

1232949

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

High-throughput

0.536

High

1232959

MYL10
Myosin regulatory light chain 10

1

1

High-throughput

0.536

High

1232985

MTUS1
Microtubule-associated tumor suppressor 1

1

1

High-throughput

0.536

High

1232989

GIT1
ARF GTPase-activating protein GIT1

1

2

High-throughput

0.536

High

1079104

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.518

High

64540

ZSWM8
Zinc finger SWIM domain-containing protein 8

1

0

High-throughput

0.513

High

212060

GATC
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial

1

0

High-throughput

0.513

High

851265

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.513

High

1023299

TRI32
E3 ubiquitin-protein ligase TRIM32

1

0

High-throughput

0.513

High

1159902

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

0

High-throughput

0.513

High

1232971

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.513

High

1232972

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.513

High

1232980

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.513

High

1232986

TTF2
Transcription termination factor 2

1

0

High-throughput

0.513

High

1232990

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

1162730

DR4L2
Dehydrogenase/reductase SDR family member 4-like 2

2

4

High-throughput

0.504

High

129317

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

1

High-throughput

0.489

High

218032

PEX1
Peroxisomal ATPase PEX1

1

1

High-throughput

0.489

High

276378

AP1G2
AP-1 complex subunit gamma-like 2

1

1

High-throughput

0.489

High

279027

RAD17
Cell cycle checkpoint protein RAD17

1

1

High-throughput

0.489

High

309500

MTMR5
Myotubularin-related protein 5

1

2

High-throughput

0.489

High

312804

M3K6
Mitogen-activated protein kinase kinase kinase 6

1

2

High-throughput

0.489

High

320544

OXSR1
Serine/threonine-protein kinase OSR1

1

2

High-throughput

0.489

High

781198

ETV3
ETS translocation variant 3

1

1

High-throughput

0.489

High

833148

VPS41
Vacuolar protein sorting-associated protein 41 homolog

1

1

High-throughput

0.489

High

840394

ERF
ETS domain-containing transcription factor ERF

1

1

High-throughput

0.489

High

842010

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

1

High-throughput

0.489

High

942004

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

1

High-throughput

0.489

High

1052104

MAP7
Ensconsin

1

2

High-throughput

0.489

High

1078031

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

1

High-throughput

0.489

High

1140610

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.489

High

1150533

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

1

High-throughput

0.489

High

1162283

WDR59
GATOR2 complex protein WDR59

1

1

High-throughput

0.489

High

1164130

WDR74
WD repeat-containing protein 74

1

1

High-throughput

0.489

High

1167924

GGYF2
GRB10-interacting GYF protein 2

1

1

High-throughput

0.489

High

1175029

TBA1A
Tubulin alpha-1A chain

1

3

High-throughput

0.489

High

1218145

CEP97
Centrosomal protein of 97 kDa

1

1

High-throughput

0.489

High

1219784

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

1

High-throughput

0.489

High

1229681

FCSK
L-fucose kinase

1

1

High-throughput

0.489

High

1232935

SHKB1
SH3KBP1-binding protein 1

1

1

High-throughput

0.489

High

1232936

IASPP
RelA-associated inhibitor

1

4

High-throughput

0.489

High

1232939

MADD
MAP kinase-activating death domain protein

1

2

High-throughput

0.489

High

1232940

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

4

High-throughput

0.489

High

1232941

RAD50
DNA repair protein RAD50

1

2

High-throughput

0.489

High

1232944

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.489

High

1232947

HOOK2
Protein Hook homolog 2

1

3

High-throughput

0.489

High

1232954

IF140
Intraflagellar transport protein 140 homolog

1

2

High-throughput

0.489

High

1232957

TBA1C
Tubulin alpha-1C chain

1

3

High-throughput

0.489

High

1232962

WDR11
WD repeat-containing protein 11

1

1

High-throughput

0.489

High

1232968

IF122
Intraflagellar transport protein 122 homolog

1

4

High-throughput

0.489

High

1232977

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

1

High-throughput

0.489

High

1232981

TBK1
Serine/threonine-protein kinase TBK1

1

2

High-throughput

0.489

High

1232982

CDC23
Cell division cycle protein 23 homolog

1

3

High-throughput

0.489

High

1232987

TBD2B
TBC1 domain family member 2B

1

2

High-throughput

0.489

High

1232988

CD11A
Cyclin-dependent kinase 11A

1

2

High-throughput

0.489

High

1232992

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

1232994

NEMO
NF-kappa-B essential modulator

1

2

High-throughput

0.489

High

1170800

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

504394

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.470

High

884537

RAB25
Ras-related protein Rab-25

1

3

High-throughput

0.437

High

1232983

APC7
Anaphase-promoting complex subunit 7

1

3

High-throughput

0.437

High

1117521

Q4KMX6
ANAPC7 protein

1

3

High-throughput

0.407

High

1232952

ZN462
Zinc finger protein 462

3

0

High-throughput

0.352

High

1232975

TRM1
tRNA

2

0

High-throughput

0.313

High

272886

KS6A4
Ribosomal protein S6 kinase alpha-4

1

0

High-throughput

0.279

Low

300932

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.279

Low

321129

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.279

Low

428305

TBB5
Tubulin beta chain

1

0

High-throughput

0.279

Low

434657

TSP1
Thrombospondin-1

1

0

High-throughput

0.279

Low

658393

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.279

Low

771216

CD79B
B-cell antigen receptor complex-associated protein beta chain

1

0

High-throughput

0.279

Low

778012

RFC3
Replication factor C subunit 3

1

0

High-throughput

0.279

Low

819100

LSS
Lanosterol synthase

1

0

High-throughput

0.279

Low

871038

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

High-throughput

0.279

Low

885879

YBEY
Endoribonuclease YbeY

1

0

High-throughput

0.279

Low

953162

CCZ1B
Vacuolar fusion protein CCZ1 homolog B

1

0

High-throughput

0.279

Low

997266

SLFN5
Schlafen family member 5

1

0

High-throughput

0.279

Low

1021872

NPRL3
GATOR1 complex protein NPRL3

1

0

High-throughput

0.279

Low

1030735

SLAF1
Signaling lymphocytic activation molecule

1

0

High-throughput

0.279

Low

1060415

KI2S3
Killer cell immunoglobulin-like receptor 2DS3

1

0

High-throughput

0.279

Low

1061496

CUL7
Cullin-7

1

0

High-throughput

0.279

Low

1069627

STK38
Serine/threonine-protein kinase 38

1

0

High-throughput

0.279

Low

1107822

EDRF1
Erythroid differentiation-related factor 1

1

0

High-throughput

0.279

Low

1109711

RGL3
Ral guanine nucleotide dissociation stimulator-like 3

1

0

High-throughput

0.279

Low

1115374

TIGIT
T-cell immunoreceptor with Ig and ITIM domains

1

0

High-throughput

0.279

Low

1123120

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

0

High-throughput

0.279

Low

1123283

PKHG4
Puratrophin-1

1

0

High-throughput

0.279

Low

1132858

ODAD2
Outer dynein arm-docking complex subunit 2

1

0

High-throughput

0.279

Low

1139837

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.279

Low

1147726

HAUS3
HAUS augmin-like complex subunit 3

1

0

High-throughput

0.279

Low

1163749

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.279

Low

1164441

SAMD1
Sterile alpha motif domain-containing protein 1

1

0

High-throughput

0.279

Low

1190372

HAUS6
HAUS augmin-like complex subunit 6

1

0

High-throughput

0.279

Low

1192294

PKHH3
Pleckstrin homology domain-containing family H member 3

1

0

High-throughput

0.279

Low

1192806

VP13B
Intermembrane lipid transfer protein VPS13B

1

0

High-throughput

0.279

Low

1201424

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

0

High-throughput

0.279

Low

1204635

MEX3D
RNA-binding protein MEX3D

1

0

High-throughput

0.279

Low

1205261

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.279

Low

1217871

MISP
Mitotic interactor and substrate of PLK1

1

0

High-throughput

0.279

Low

1223345

TRM44
Probable tRNA

1

0

High-throughput

0.279

Low

1232165

VW5B2
von Willebrand factor A domain-containing protein 5B2

1

0

High-throughput

0.279

Low

1232933

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.279

Low

1232934

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

High-throughput

0.279

Low

1232937

CTF18
Chromosome transmission fidelity protein 18 homolog

1

0

High-throughput

0.279

Low

1232938

ARAP3
Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

1

0

High-throughput

0.279

Low

1232942

HPS3
BLOC-2 complex member HPS3

1

0

High-throughput

0.279

Low

1232943

PLPL2
Patatin-like phospholipase domain-containing protein 2

1

0

High-throughput

0.279

Low

1232945

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.279

Low

1232946

NUD16
U8 snoRNA-decapping enzyme

1

0

High-throughput

0.279

Low

1232948

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.279

Low

1232950

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.279

Low

1232951

SPTCS
Spatacsin

1

0

High-throughput

0.279

Low

1232953

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.279

Low

1232955

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.279

Low

1232956

RGPD5
RANBP2-like and GRIP domain-containing protein 5/6

1

0

High-throughput

0.279

Low

1232958

TBCD
Tubulin-specific chaperone D

1

0

High-throughput

0.279

Low

1232960

THUM3
tRNA

1

0

High-throughput

0.279

Low

1232961

K1671
Uncharacterized protein KIAA1671

1

0

High-throughput

0.279

Low

1232963

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.279

Low

1232964

APC1
Anaphase-promoting complex subunit 1

1

0

High-throughput

0.279

Low

1232965

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.279

Low

1232966

TRABD
TraB domain-containing protein

1

0

High-throughput

0.279

Low

1232967

ESRP2
Epithelial splicing regulatory protein 2

1

0

High-throughput

0.279

Low

1232969

TF7L2
Transcription factor 7-like 2

1

0

High-throughput

0.279

Low

1232970

ARHG4
Rho guanine nucleotide exchange factor 4

1

0

High-throughput

0.279

Low

1232973

ABCF3
ATP-binding cassette sub-family F member 3

1

0

High-throughput

0.279

Low

1232974

UCKL1
Uridine-cytidine kinase-like 1

1

0

High-throughput

0.279

Low

1232976

RTEL1
Regulator of telomere elongation helicase 1

1

0

High-throughput

0.279

Low

1232978

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

1232979

P2RX2
P2X purinoceptor 2

1

0

High-throughput

0.279

Low

1232984

CNO11
CCR4-NOT transcription complex subunit 11

1

0

High-throughput

0.279

Low

1232991

TELO2
Telomere length regulation protein TEL2 homolog

1

0

High-throughput

0.279

Low

1232993

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

0

High-throughput

0.279

Low

789160

HELZ
Probable helicase with zinc finger domain

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024