HitPredict

Interactor 1: GRB2 (Q60631)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2)
Gene: GRB2

Interactor 2: SOS1 (Q62245)
Son of sevenless homolog 1 (SOS-1) (mSOS-1)
Gene: SOS1

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.887

The method score is based on:

Property Details
Experiments 10373493, 8479540, 9569023, 23452850
Identification Methods affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, pull down
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains RhoGEF~SH3_1, SH3_1~SOS1_NGEF_PH
Common GO terms GO:0005154 - epidermal growth factor receptor binding
GO:0005829 - cytosol
GO:0007173 - epidermal growth factor receptor signaling pathway
GO:0007265 - Ras protein signal transduction
GO:0008286 - insulin receptor signaling pathway
and 8 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 217
Mm

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Service provided by Combinatics, Japan

Last updated: 11Aug2025