HitPredict

Interactor 1: SHAN2 (Q80Z38)
SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1)
Gene: Shank2

Interactor 2: HOME1 (Q9Z2Y3)
Homer protein homolog 1 (Homer-1) (VASP/Ena-related gene up-regulated during seizure and LTP 1) (Vesl-1)
Gene: Homer1

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	28671696
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0014069 - postsynaptic density GO:0043005 - neuron projection GO:0043197 - dendritic spine
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1476 Mm			1 366
+	Rn
		1455871 SHAN2_RAT (1-1476): 1.31e-165: 539: 98.17		HOME1_RAT (1-366): 8.39e-85: 263: 98.09
+	Hs
		1295230 SHAN2_HUMAN (13-1476): 1.1e-160: 533: 88.33		HOME1_HUMAN (1-366): 4.31e-83: 258: 94.81
+	Mm
		1194004 SHAN3_MOUSE (13-1473): 1.9e-75: 279: 33.04		HOME1_MOUSE (1-366): 1.15e-85: 265: 100.00
+	Rn
		1440931 SHAN3_RAT (13-1473): 4.31e-73: 272: 32.84		HOME1_RAT (1-366): 8.39e-85: 263: 98.09
+	Mm
		1193969 SHAN3_MOUSE (13-1473): 1.9e-75: 279: 33.04		HOME2_MOUSE (1-362): 7.57e-76: 239: 51.11
+	Hs
		1417966 SHAN3_HUMAN (13-1473): 1.93e-76: 283: 33.54		HOME2_HUMAN (1-362): 2.6e-73: 233: 51.38
+	Hs
		1417967 SHAN3_HUMAN (13-1473): 1.93e-76: 283: 33.54		HOME3_HUMAN (3-366): 7.28e-70: 224: 48.91
+	Mm
		1193896 SHAN3_MOUSE (13-1473): 1.9e-75: 279: 33.04		HOME3_MOUSE (3-366): 2.42e-69: 223: 46.98
+	Mm
		1193797 SHAN3_MOUSE (13-1473): 1.9e-75: 279: 33.04		MRCKB_MOUSE (1-348): 8.06e-64: 222: 18.73
+	Mm
		878601 SHAN3_MOUSE (13-1473): 1.9e-75: 279: 33.04		CTRO_MOUSE (17-366): 5.93e-36: 141: 12.95
+	Hs
		1417981 SHAN3_HUMAN (13-1473): 1.93e-76: 283: 33.54		EP15R_HUMAN (115-364): 2.64e-32: 130: 16.67
+	Mm
		1000407 SHAN3_MOUSE (13-1473): 1.9e-75: 279: 33.04		EVL_MOUSE (1-167): 1.77e-23: 102: 20.35
+	Dm
		55862 A1Z9K8_DROME (227-561): 1.26e-38: 160: 25.19		M9PEX1_DROME (1-346): 1.2e-60: 202: 34.83
+	Hs
		157740 SNX27_HUMAN (245-499): 4.12e-42: 165: 23.94		CTRO_HUMAN (12-364): 1.37e-45: 169: 13.04
+	Hs
		1106292 SNX27_HUMAN (245-499): 4.12e-42: 165: 23.94		ROCK1_HUMAN (1-364): 9.86e-39: 149: 16.58
+	Hs
		896551 RHG21_HUMAN (242-1010): 2.37e-39: 162: 14.30		VASP_HUMAN (1-359): 1.5e-34: 132: 15.51
+	Hs
		208638 SI1L1_HUMAN (206-1019): 1.19e-36: 154: 12.46		VASP_HUMAN (1-359): 1.5e-34: 132: 15.51
+	Hs
		244554 SI1L3_HUMAN (206-1008): 7.88e-36: 151: 11.30		VASP_HUMAN (1-359): 1.5e-34: 132: 15.51
+	Hs
		1213075 RHG21_HUMAN (242-1010): 2.37e-39: 162: 14.30		MY18A_HUMAN (109-361): 6.1e-28: 117: 14.63
+	Hs
		244596 SI1L3_HUMAN (206-1008): 7.88e-36: 151: 11.30		MY18A_HUMAN (109-361): 6.1e-28: 117: 14.63