HitPredict

Interactor 1: MINK1 (Q8N4C8)
Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)
Gene: MINK1

Interactor 2: SH24A (Q9H788)
SH2 domain-containing protein 4A (Protein SH(2)A) (Protein phosphatase 1 regulatory subunit 38)
Gene: SH2D4A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1332 Hs			1 454
+	Hs
		987773 MINK1_HUMAN (1-1332): 0: 1292: 100.00		GRB2_HUMAN (310-454): 8.07e-41: 147: 24.83
+	Hs
		222144 MINK1_HUMAN (1-1332): 0: 1292: 100.00		NCK2_HUMAN (281-428): 1.14e-23: 103: 24.16
+	Hs
		594048 MINK1_HUMAN (1-1332): 0: 1292: 100.00		NCK1_HUMAN (346-428): 2.06e-20: 94.6: 32.14
+	Hs
		222223 TNIK_HUMAN (1-1332): 0: 1110: 60.76		NCK2_HUMAN (281-428): 1.14e-23: 103: 24.16
+	Hs
		594130 TNIK_HUMAN (1-1332): 0: 1110: 60.76		NCK1_HUMAN (346-428): 2.06e-20: 94.6: 32.14
+	Hs
		348101 M4K4_HUMAN (1-1332): 0: 1044: 57.66		GRB2_HUMAN (310-454): 8.07e-41: 147: 24.83
+	Hs
		221993 M4K4_HUMAN (1-1332): 0: 1044: 57.66		NCK2_HUMAN (281-428): 1.14e-23: 103: 24.16
+	Hs
		348050 M4K4_HUMAN (1-1332): 0: 1044: 57.66		NCK1_HUMAN (346-428): 2.06e-20: 94.6: 32.14
+	Hs
		348053 M4K4_HUMAN (1-1332): 0: 1044: 57.66		RASA1_HUMAN (347-454): 9.62e-14: 75.7: 24.77
+	Mm
		1021947 M4K4_MOUSE (1-1332): 0: 1002: 56.47		NCK1_MOUSE (346-428): 1.6e-20: 94.6: 32.14
+	Ce
		1171296 MIG15_CAEEL (5-703): 4.06e-115: 389: 39.47		Q95PW9_CAEEL (63-442): 9.04e-54: 186: 15.21
+	Hs
		987804 MYO3B_HUMAN (13-329): 8.37e-114: 390: 47.71		GRB2_HUMAN (310-454): 8.07e-41: 147: 24.83
+	Hs
		593917 MARK3_HUMAN (16-748): 1.46e-133: 430: 14.72		NCK1_HUMAN (346-428): 2.06e-20: 94.6: 32.14
+	Hs
		1094308 M4K3_HUMAN (17-441): 5.94e-110: 370: 37.06		LCP2_HUMAN (113-433): 3.7e-40: 152: 15.09
+	Hs
		987753 M4K3_HUMAN (17-441): 5.94e-110: 370: 37.06		GRB2_HUMAN (310-454): 8.07e-41: 147: 24.83
+	Dm
		1061424 Q7KV89_DROME (3-770): 1.22e-123: 413: 41.24		GRAP_DROME (320-443): 4.45e-17: 81.5: 28.91
+	Hs
		699769 M3K11_HUMAN (26-779): 2.14e-120: 397: 21.38		P85A_HUMAN (342-445): 3.24e-19: 92.3: 22.02
+	Hs
		594039 M4K3_HUMAN (17-441): 5.94e-110: 370: 37.06		NCK1_HUMAN (346-428): 2.06e-20: 94.6: 32.14
+	Hs
		988064 M4K5_HUMAN (5-307): 7e-71: 257: 45.60		GRB2_HUMAN (310-454): 8.07e-41: 147: 24.83
+	Hs
		594152 M4K5_HUMAN (5-307): 7e-71: 257: 45.60		NCK1_HUMAN (346-428): 2.06e-20: 94.6: 32.14