HitPredict

Interactor 1: RN138 (Q8WVD3)
E3 ubiquitin-protein ligase RNF138 (EC 2.3.2.27) (Nemo-like kinase-associated RING finger protein) (NLK-associated RING finger protein) (hNARF) (RING finger protein 138) (RING-type E3 ubiquitin transferase RNF138)
Gene: RNF138

Interactor 2: TF7L2 (Q9NQB0)
Transcription factor 7-like 2 (HMG box transcription factor 4) (T-cell-specific transcription factor 4) (T-cell factor 4) (TCF-4) (hTCF-4)
Gene: TCF7L2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	0.60	0.561

Property	Details
Experiments	16714285
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0019901 - protein kinase binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 245 Hs			1 619
+	Hs
		1357996 RN138_HUMAN (1-245): 4.92e-57: 183: 100.00		LEF1_HUMAN (11-444): 1.93e-40: 153: 48.63
+	Hs
		623494 RO52_HUMAN (6-157): 1.66e-31: 122: 17.11		CIC_HUMAN (32-578): 2.48e-34: 142: 15.58
+	Hs
		1315293 TRI22_HUMAN (11-171): 3.51e-29: 116: 14.97		CIC_HUMAN (32-578): 2.48e-34: 142: 15.58
+	Hs
		1401359 RING2_HUMAN (2-188): 4.61e-29: 113: 18.72		CIC_HUMAN (32-578): 2.48e-34: 142: 15.58
+	Mm
		873043 RING2_MOUSE (2-188): 1.07e-28: 112: 18.72		SOX2_MOUSE (318-613): 3.22e-33: 131: 14.15
+	Hs
		776178 RING1_HUMAN (2-74): 3.96e-21: 92.7: 27.40		SOX6_HUMAN (41-503): 4.91e-37: 149: 11.63
+	Hs
		1065356 RN125_HUMAN (2-245): 6.67e-33: 121: 26.64		SSRP1_HUMAN (333-511): 5.9e-26: 115: 18.89
+	Hs
		872267 TRI26_HUMAN (3-239): 1.51e-32: 125: 15.57		SOX2_HUMAN (311-614): 4.16e-26: 111: 15.39
+	Hs
		1055845 RING1_HUMAN (2-74): 3.96e-21: 92.7: 27.40		CIC_HUMAN (32-578): 2.48e-34: 142: 15.58
+	Hs
		1065386 RING2_HUMAN (2-188): 4.61e-29: 113: 18.72		SSRP1_HUMAN (333-511): 5.9e-26: 115: 18.89
+	Mm
		1423704 RING2_MOUSE (2-188): 1.07e-28: 112: 18.72		HM20A_MOUSE (248-463): 1.94e-26: 112: 11.57
+	Hs
		872665 RING2_HUMAN (2-188): 4.61e-29: 113: 18.72		SOX2_HUMAN (311-614): 4.16e-26: 111: 15.39
+	Hs
		1414786 TRAF4_HUMAN (8-207): 2.41e-27: 110: 13.14		HM20A_HUMAN (248-463): 7.23e-26: 111: 13.83
+	Hs
		872826 KCMF1_HUMAN (147-236): 1.38e-25: 105: 32.22		SOX2_HUMAN (311-614): 4.16e-26: 111: 15.39