HitPredict

Interactor 1: P85B (O00459)
Phosphatidylinositol 3-kinase regulatory subunit beta (PI3-kinase regulatory subunit beta) (PI3K regulatory subunit beta) (PtdIns-3-kinase regulatory subunit beta) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta) (PI3-kinase subunit p85-beta) (PtdIns-3-kinase regulatory subunit p85-beta)
Gene: PIK3R2

Interactor 2: VGFR3 (P35916)
Vascular endothelial growth factor receptor 3 (VEGFR-3) (EC 2.7.10.1) (Fms-like tyrosine kinase 4) (FLT-4) (Tyrosine-protein kinase receptor FLT4)
Gene: FLT4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005634 - nucleus GO:0019903 - protein phosphatase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 728 Hs			1 1363
+	Hs
		136345 P85B_HUMAN (1-728): 0: 541: 100.00		EPHA5_HUMAN (373-1201): 2.04e-158: 506: 13.96
+	Hs
		136300 P85B_HUMAN (1-728): 0: 541: 100.00		EPHA3_HUMAN (386-1200): 1.58e-154: 494: 14.51
+	Hs
		136302 P85B_HUMAN (1-728): 0: 541: 100.00		EPHB2_HUMAN (392-1320): 1.78e-152: 490: 13.00
+	Hs
		136391 P85B_HUMAN (1-728): 0: 541: 100.00		EPHA7_HUMAN (391-1212): 7.64e-153: 490: 14.51
+	Hs
		931877 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		EPHA5_HUMAN (373-1201): 2.04e-158: 506: 13.96
+	Hs
		136261 P85B_HUMAN (1-728): 0: 541: 100.00		RET_HUMAN (801-1176): 1.26e-74: 273: 40.63
+	Hs
		136267 P85B_HUMAN (1-728): 0: 541: 100.00		PGFRB_HUMAN (19-639): 3.02e-62: 234: 18.20
+	Hs
		136282 P85B_HUMAN (1-728): 0: 541: 100.00		PGFRA_HUMAN (9-639): 1.28e-58: 223: 17.92
+	Hs
		136269 P85B_HUMAN (1-728): 0: 541: 100.00		KIT_HUMAN (15-549): 2.69e-52: 202: 18.30
+	Dm
		117918 SRC42_DROME (551-727): 4.13e-35: 142: 22.78		M9MRE1_DROME (24-1359): 5.29e-173: 557: 17.65
+	Hs
		136292 P85B_HUMAN (1-728): 0: 541: 100.00		FGFR4_HUMAN (2-238): 3.8e-26: 118: 13.21
+	Hs
		136256 P85B_HUMAN (1-728): 0: 541: 100.00		CSF1R_HUMAN (1-347): 3.92e-22: 105: 9.68
+	Mm
		148471 P85B_MOUSE (1-728): 3.84e-179: 530: 88.87		KIT_MOUSE (4-424): 6.17e-24: 111: 11.80
+	Hs
		136275 P85B_HUMAN (1-728): 0: 541: 100.00		FGFR1_HUMAN (2-160): 3.16e-15: 83.1: 11.31
+	Hs
		136290 P85B_HUMAN (1-728): 0: 541: 100.00		FGFR2_HUMAN (2-149): 3.84e-14: 79.7: 14.10
+	Hs
		484194 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		PGFRB_HUMAN (19-639): 3.02e-62: 234: 18.20
+	Hs
		593458 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		PGFRA_HUMAN (9-639): 1.28e-58: 223: 17.92
+	Hs
		532095 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		KIT_HUMAN (15-549): 2.69e-52: 202: 18.30
+	Hs
		648609 P55G_HUMAN (313-722): 1.49e-99: 316: 72.02		FGFR4_HUMAN (2-238): 3.8e-26: 118: 13.21
+	Hs
		532057 TXK_HUMAN (550-727): 2.67e-33: 137: 23.24		KIT_HUMAN (15-549): 2.69e-52: 202: 18.30