HitPredict

Interactor 1: CSN2 (O01422)
COP9 signalosome complex subunit 2 (Signalosome subunit 2)
Gene: csn-2

Interactor 2: CSN6 (Q95PZ0)
COP9 signalosome complex subunit 6 (Signalosome subunit 6)
Gene: csn-6

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	1.00	0.775

Property	Details
Experiments	12781129, 17403899
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	JAB~PCI, MitMem_reg~PCI
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0008180 - COP9 signalosome GO:0048477 - oogenesis GO:0060184 - cell cycle switching and 1 others more... GO:1905879 - regulation of oogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 495 Ce			1 426
+	Mm
		291866 CSN2_MOUSE (1-428): 7.13e-122: 365: 63.66		CSN6_MOUSE (9-298): 6.46e-95: 289: 28.81
+	Hs
		897267 CSN2_HUMAN (1-428): 7.13e-122: 365: 63.66		CSN6_HUMAN (9-298): 1.45e-94: 289: 29.15
+	Mm
		102343 G3UXW9_MOUSE (13-472): 8.99e-110: 337: 13.05		CSN6_MOUSE (9-298): 6.46e-95: 289: 28.81
+	Dm
		1277032 CSN2_DROME (12-428): 4.83e-114: 345: 64.13		CSN6_DROME (1-298): 1.57e-89: 276: 31.35
+	Mm
		291868 CSN1_MOUSE (13-472): 8.51e-109: 332: 13.05		CSN6_MOUSE (9-298): 6.46e-95: 289: 28.81
+	Hs
		1024178 CSN1_HUMAN (13-472): 3.26e-106: 327: 12.74		CSN6_HUMAN (9-298): 1.45e-94: 289: 29.15
+	Hs
		121968 PSD12_HUMAN (25-447): 9.28e-95: 296: 11.59		PSMD7_HUMAN (10-300): 9.77e-91: 279: 20.82
+	Hs
		121804 PSD11_HUMAN (31-435): 3.28e-85: 270: 20.00		CSN6_HUMAN (9-298): 1.45e-94: 289: 29.15
+	Dm
		640773 PSD11_DROME (22-435): 1.14e-83: 266: 19.24		PSMD7_DROME (10-343): 9.66e-96: 292: 19.29
+	Hs
		121709 PSD11_HUMAN (31-435): 3.28e-85: 270: 20.00		PSMD7_HUMAN (10-300): 9.77e-91: 279: 20.82
+	Dm
		640777 PSMD6_DROME (87-437): 2.4e-79: 254: 11.75		PSMD7_DROME (10-343): 9.66e-96: 292: 19.29
+	Dm
		640782 Q9V3Z4_DROME (30-435): 3.87e-76: 249: 10.99		PSMD7_DROME (10-343): 9.66e-96: 292: 19.29
+	Hs
		849202 PSMD6_HUMAN (91-437): 2e-81: 259: 14.09		PSMD7_HUMAN (10-300): 9.77e-91: 279: 20.82
+	Hs
		1184960 CSN4_HUMAN (79-448): 1.61e-69: 229: 14.50		CSN6_HUMAN (9-298): 1.45e-94: 289: 29.15
+	Mm
		291852 CSN4_MOUSE (79-448): 1.94e-69: 229: 14.50		CSN6_MOUSE (9-298): 6.46e-95: 289: 28.81
+	Sc
		996269 RPN6_YEAST (21-434): 7.6e-79: 254: 16.86		RPN8_YEAST (12-355): 2.34e-83: 260: 20.74
+	Hs
		121895 PSD12_HUMAN (25-447): 9.28e-95: 296: 11.59		EIF3H_HUMAN (8-311): 7.67e-66: 215: 12.50
+	Dm
		1358198 CSN4_DROME (78-439): 6.63e-61: 206: 14.04		CSN6_DROME (1-298): 1.57e-89: 276: 31.35
+	At
		1226049 CSN4_ARATH (69-430): 9.96e-58: 198: 15.05		CSN6A_ARATH (5-297): 3.6e-89: 274: 23.34
+	At
		1226054 CSN4_ARATH (69-430): 9.96e-58: 198: 15.05		EIF3H_ARATH (1-294): 2.59e-52: 180: 12.26