HitPredict

Interactor 1: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Interactor 2: ARHGH (Q96PE2)
Rho guanine nucleotide exchange factor 17 (164 kDa Rho-specific guanine-nucleotide exchange factor) (p164-RhoGEF) (p164RhoGEF) (Tumor endothelial marker 4)
Gene: ARHGEF17

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 665 Hs			1 2063
+	Hs
		1154148 SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00		ITSN1_HUMAN (565-1518): 1.17e-99: 359: 14.74
+	Hs
		1384281 SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00		ITSN2_HUMAN (587-1518): 1.18e-93: 339: 13.15
+	Dm
		1305249 Q9VA36_DROME (2-580): 3.86e-46: 177: 22.38		Q8IQ97_DROME (601-1501): 5.03e-95: 340: 16.81
+	Hs
		594071 NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62		ARHG2_HUMAN (938-1740): 2.49e-105: 364: 15.50
+	Hs
		539994 GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37		BCR_HUMAN (688-1499): 1.68e-94: 338: 19.82
+	Hs
		987726 GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37		FGD6_HUMAN (652-1515): 1.64e-92: 334: 15.31
+	Hs
		584510 GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37		VAV_HUMAN (973-1660): 2.17e-95: 331: 14.77
+	Hs
		987850 GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37		Q96D37_HUMAN (973-1660): 6.42e-96: 331: 14.77
+	Mm
		699355 GRB2_MOUSE (2-158): 8.55e-35: 133: 20.37		VAV_MOUSE (973-1664): 2.6e-94: 328: 14.55
+	Hs
		72966 GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37		B1ALK7_HUMAN (998-1669): 8.36e-94: 323: 14.41
+	Mm
		1221229 GRB2_MOUSE (2-158): 8.55e-35: 133: 20.37		BCR_MOUSE (854-1499): 1.59e-81: 297: 20.91
+	Hs
		299546 ARHG7_HUMAN (2-595): 6.82e-34: 140: 16.23		TRIO_HUMAN (1051-1752): 1.63e-76: 286: 15.46
+	Hs
		987948 GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37		ECT2_HUMAN (984-1451): 4.23e-72: 263: 21.08
+	Hs
		1121949 ARHG7_HUMAN (2-595): 6.82e-34: 140: 16.23		ARHG6_HUMAN (1070-1382): 7.72e-70: 253: 21.20
+	Mm
		1221220 GRB2_MOUSE (2-158): 8.55e-35: 133: 20.37		VAV2_MOUSE (1056-1352): 7.38e-69: 253: 23.84
+	Hs
		594104 NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62		ECT2_HUMAN (984-1451): 4.23e-72: 263: 21.08
+	Hs
		594004 NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62		ARHG6_HUMAN (1070-1382): 7.72e-70: 253: 21.20
+	Hs
		222084 NCK2_HUMAN (244-432): 3.03e-17: 86.2: 21.24		ARHG6_HUMAN (1070-1382): 7.72e-70: 253: 21.20
+	Hs
		988017 GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37		VAV3_HUMAN (1046-1323): 6.44e-18: 92.8: 27.72
+	Hs
		913636 GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37		VAV2_HUMAN (1065-1328): 1.92e-15: 84.7: 26.57