HitPredict

Interactor 1: SH3K1 (Q96B97)
SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)
Gene: SH3KBP1

Interactor 2: ZO2 (Q9UDY2)
Tight junction protein 2 (Tight junction protein ZO-2) (Zona occludens protein 2) (Zonula occludens protein 2)
Gene: TJP2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	12829691, 34079125, unassigned3799
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH3_2~SH3_9
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 665 Hs			1 1190
+	Hs
		1458940 CD2AP_HUMAN (1-664): 1.84e-95: 309: 32.36		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		1205171 SH319_HUMAN (9-367): 1.66e-24: 111: 14.76		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		1251275 DNMBP_HUMAN (4-581): 5.37e-24: 110: 12.50		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Hs
		222222 NCK2_HUMAN (244-432): 3.03e-17: 86.2: 21.24		ZO2_HUMAN (1-1190): 0: 838: 100.00
+	Mm
		1223673 SH3K1_MOUSE (1-665): 2.78e-119: 373: 87.87		DLG4_MOUSE (3-535): 2.19e-54: 205: 15.57
+	Hs
		1058852 SH319_HUMAN (9-367): 1.66e-24: 111: 14.76		ZO1_HUMAN (25-1176): 1.61e-132: 446: 36.74
+	Hs
		1058866 DNMBP_HUMAN (4-581): 5.37e-24: 110: 12.50		ZO1_HUMAN (25-1176): 1.61e-132: 446: 36.74
+	Hs
		1325302 SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00		PALS1_HUMAN (455-886): 1.78e-39: 159: 19.67
+	Hs
		1351374 SH3K1_HUMAN (1-665): 1.57e-126: 391: 100.00		DLG5_HUMAN (25-522): 3.4e-14: 80: 11.77
+	Hs
		168689 ARHG7_HUMAN (2-595): 6.82e-34: 140: 16.23		CSKP_HUMAN (229-890): 7.83e-90: 312: 14.96
+	Mm
		1221224 GRB2_MOUSE (2-158): 8.55e-35: 133: 20.37		DLG4_MOUSE (3-535): 2.19e-54: 205: 15.57
+	Hs
		987532 GRB2_HUMAN (2-158): 8.55e-35: 133: 20.37		DLG4_HUMAN (3-535): 1.47e-54: 205: 15.57
+	Mm
		237076 NCK2_MOUSE (244-432): 4.01e-16: 82.8: 22.28		DLG4_MOUSE (3-535): 2.19e-54: 205: 15.57
+	Mm
		1223547 SRBS1_MOUSE (3-155): 1.1e-13: 77: 34.15		DLG4_MOUSE (3-535): 2.19e-54: 205: 15.57
+	Mm
		1223635 SH3R3_MOUSE (201-534): 8.45e-13: 73.9: 11.40		DLG4_MOUSE (3-535): 2.19e-54: 205: 15.57
+	Mm
		1190848 SRBS2_MOUSE (3-155): 3.33e-11: 68.9: 30.86		DLG4_MOUSE (3-535): 2.19e-54: 205: 15.57
+	Hs
		594054 NCK1_HUMAN (104-413): 3.74e-26: 112: 16.62		DLG5_HUMAN (25-522): 3.4e-14: 80: 11.77
+	Dm
		1061455 GRAP_DROME (2-157): 3.83e-32: 125: 18.01		Q9VHK4_DROME (17-123): 2.02e-09: 64.4: 23.15
+	Hs
		222156 NCK2_HUMAN (244-432): 3.03e-17: 86.2: 21.24		DLG5_HUMAN (25-522): 3.4e-14: 80: 11.77
+	Hs
		250297 VINEX_HUMAN (67-445): 6.54e-15: 80.5: 19.82		DLG5_HUMAN (25-522): 3.4e-14: 80: 11.77