HitPredict

Interactor 1: MYD88 (Q99836)
Myeloid differentiation primary response protein MyD88
Gene: MYD88

Interactor 2: TLR10 (Q9BXR5)
Toll-like receptor 10 (CD antigen CD290)
Gene: TLR10

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	15728506
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0045087 - innate immune response
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 296 Hs			1 811
+	Hs
		1148233 MYD88_HUMAN (14-296): 6.53e-129: 370: 100.00		TLR1_HUMAN (19-785): 5.48e-105: 342: 48.77
+	Hs
		1407684 MYD88_HUMAN (14-296): 6.53e-129: 370: 100.00		TLR6_HUMAN (23-790): 4.19e-104: 340: 47.16
+	Mm
		648083 MYD88_MOUSE (1-296): 7.7e-133: 380: 81.76		TLR2_MOUSE (7-775): 1.82e-96: 319: 28.26
+	Hs
		252368 MYD88_HUMAN (14-296): 6.53e-129: 370: 100.00		TLR2_HUMAN (7-775): 5.71e-95: 316: 27.11
+	Hs
		1417231 TLR10_HUMAN (141-295): 8.62e-54: 189: 19.39		TLR10_HUMAN (1-811): 4.52e-125: 396: 100.00
+	Hs
		1148235 TLR10_HUMAN (141-295): 8.62e-54: 189: 19.39		TLR1_HUMAN (19-785): 5.48e-105: 342: 48.77
+	Hs
		1417235 TLR10_HUMAN (141-295): 8.62e-54: 189: 19.39		TLR6_HUMAN (23-790): 4.19e-104: 340: 47.16
+	Hs
		252372 TLR10_HUMAN (141-295): 8.62e-54: 189: 19.39		TLR2_HUMAN (7-775): 5.71e-95: 316: 27.11
+	Mm
		648078 MYD88_MOUSE (1-296): 7.7e-133: 380: 81.76		TLR9_MOUSE (15-523): 3.42e-26: 117: 14.79
+	Hs
		1407673 MYD88_HUMAN (14-296): 6.53e-129: 370: 100.00		TLR9_HUMAN (13-599): 7.25e-26: 116: 13.47
+	Hs
		1407678 MYD88_HUMAN (14-296): 6.53e-129: 370: 100.00		TLR7_HUMAN (15-680): 3.24e-24: 111: 12.63
+	Dm
		1264485 Q7K105_DROME (18-293): 3.38e-90: 279: 25.48		TOLL7_DROME (32-550): 2.98e-44: 175: 15.94
+	Hs
		252286 MYD88_HUMAN (14-296): 6.53e-129: 370: 100.00		TLR5_HUMAN (2-334): 5.84e-15: 81.2: 15.74
+	Hs
		191235 MYD88_HUMAN (14-296): 6.53e-129: 370: 100.00		TLR3_HUMAN (223-519): 1e-13: 77.3: 13.25
+	Mm
		648082 MYD88_MOUSE (1-296): 7.7e-133: 380: 81.76		TLR4_MOUSE (4-470): 2.37e-10: 66.5: 13.38
+	Hs
		1407674 MYD88_HUMAN (14-296): 6.53e-129: 370: 100.00		TLR8_HUMAN (1-206): 5.91e-13: 75: 16.67
+	Hs
		126332 MYD88_HUMAN (14-296): 6.53e-129: 370: 100.00		TLR4_HUMAN (4-433): 1.57e-11: 70: 9.91
+	Dm
		1264489 Q7K105_DROME (18-293): 3.38e-90: 279: 25.48		TOLL6_DROME (168-552): 2.66e-23: 108: 13.88
+	Dm
		477358 Q7K105_DROME (18-293): 3.38e-90: 279: 25.48		TOLL_DROME (216-650): 2.81e-19: 95.4: 12.28
+	Dm
		477362 Q9VJX9_DROME (151-294): 1.01e-50: 180: 22.67		TOLL_DROME (216-650): 2.81e-19: 95.4: 12.28