HitPredict

Interactor 1: Q9QUH1 (Q9QUH1)
F-box/WD repeat-containing protein 2 (F-box and WD-40 domain-containing protein 2) (Protein MD6)
Gene: Fbxw2

Interactor 2: CUL1 (Q9WTX6)
Cullin-1 (CUL-1)
Gene: CUL1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.80	0.675

Property	Details
Experiments	10585767, 11735228
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cullin~F-box-like
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 454 Mm			1 776
+	Hs
		1112787 FBXW2_HUMAN (1-453): 3.48e-103: 316: 98.68		CUL1_HUMAN (1-776): 0: 909: 99.87
+	Mm
		1353853 FBXW7_MOUSE (87-432): 4.15e-83: 271: 20.68		CUL1_MOUSE (1-776): 0: 911: 100.00
+	Hs
		1112642 FBXW7_HUMAN (87-432): 2.26e-82: 269: 20.40		CUL1_HUMAN (1-776): 0: 909: 99.87
+	Hs
		964926 WDR5_HUMAN (221-452): 8.05e-56: 189: 19.15		CUL1_HUMAN (1-776): 0: 909: 99.87
+	Mm
		1190511 FBW1A_MOUSE (214-451): 4.29e-38: 148: 16.87		CUL1_MOUSE (1-776): 0: 911: 100.00
+	Hs
		1115343 FBXW7_HUMAN (87-432): 2.26e-82: 269: 20.40		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Hs
		845297 LIS1_HUMAN (55-353): 8.34e-72: 234: 19.45		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		845298 LIS1_HUMAN (55-353): 8.34e-72: 234: 19.45		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Hs
		964928 WDR5_HUMAN (221-452): 8.05e-56: 189: 19.15		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		964929 WDR5_HUMAN (221-452): 8.05e-56: 189: 19.15		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Hs
		1114950 POC1B_HUMAN (213-451): 8.38e-50: 178: 13.64		CUL4A_HUMAN (7-776): 0: 781: 30.41
+	Hs
		1115313 POC1B_HUMAN (213-451): 8.38e-50: 178: 13.64		CUL4B_HUMAN (7-776): 0: 773: 29.90
+	Hs
		1114438 NLE1_HUMAN (31-304): 4.15e-54: 189: 14.59		CUL3_HUMAN (9-776): 0: 747: 30.47
+	Hs
		964927 WDR5_HUMAN (221-452): 8.05e-56: 189: 19.15		CUL3_HUMAN (9-776): 0: 747: 30.47
+	Hs
		1113779 POC1B_HUMAN (213-451): 8.38e-50: 178: 13.64		CUL3_HUMAN (9-776): 0: 747: 30.47
+	Hs
		222479 PLRG1_HUMAN (179-451): 7.79e-48: 173: 20.00		CUL3_HUMAN (9-776): 0: 747: 30.47
+	Dm
		1173425 Q9VDE3_DROME (212-451): 1.75e-37: 144: 15.26		CUL1_DROME (4-776): 0: 770: 61.98
+	Sc
		809301 MET30_YEAST (7-432): 5.65e-85: 275: 21.15		CDC53_YEAST (13-776): 0: 628: 31.36
+	Sc
		460748 CDC4_YEAST (19-417): 1.05e-73: 248: 17.50		CDC53_YEAST (13-776): 0: 628: 31.36
+	Sp
		151352 POP1_SCHPO (116-291): 7.18e-26: 112: 16.48		CUL1_SCHPO (1-776): 0: 733: 41.04