HitPredict

Interactor 1: Q9VBI3 (Q9VBI3)
RH72336p (Vacuolar protein sorting 2)
Gene: Vps2

Interactor 2: Q9Y162 (Q9Y162)
vesicle-fusing ATPase (EC 3.6.4.6)
Gene: Vps4

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.629

Property	Details
Experiments	22036573, 19079254, 38944040
Identification Methods	affinity chromatography technology, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0016197 - endosomal transport GO:0043162 - ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 256 Dm			1 442
+	Hs
		221893 CHM2A_HUMAN (1-190): 1.62e-41: 143: 77.90		VPS4A_HUMAN (6-441): 4.97e-126: 374: 73.85
+	Hs
		221821 CHM2A_HUMAN (1-190): 1.62e-41: 143: 77.90		VPS4B_HUMAN (2-442): 1.93e-125: 372: 74.21
+	Dm
		1484932 Q9VRJ5_DROME (2-213): 4.33e-39: 136: 32.08		Q9Y162_DROME (1-442): 9.23e-128: 378: 100.00
+	Hs
		1462136 CHM2B_HUMAN (7-212): 4.1e-40: 139: 33.50		VPS4A_HUMAN (6-441): 4.97e-126: 374: 73.85
+	Mm
		857265 CHM2A_MOUSE (1-199): 9.43e-41: 141: 75.38		VPS4B_MOUSE (2-442): 7.58e-125: 371: 75.34
+	Hs
		276933 CHM2B_HUMAN (7-212): 4.1e-40: 139: 33.50		VPS4B_HUMAN (2-442): 1.93e-125: 372: 74.21
+	Hs
		1462137 CHMP3_HUMAN (4-194): 7.45e-39: 136: 23.83		VPS4A_HUMAN (6-441): 4.97e-126: 374: 73.85
+	Dm
		1482284 Q9VN02_DROME (4-208): 7.13e-35: 126: 23.19		Q9Y162_DROME (1-442): 9.23e-128: 378: 100.00
+	Hs
		1453651 CHMP5_HUMAN (1-203): 2.24e-36: 129: 19.05		VPS4A_HUMAN (6-441): 4.97e-126: 374: 73.85
+	Dm
		1377984 Q95SH2_DROME (14-215): 1.39e-34: 124: 26.73		Q9Y162_DROME (1-442): 9.23e-128: 378: 100.00
+	Dm
		1487331 CHMP5_DROME (1-206): 1.7e-33: 123: 18.31		Q9Y162_DROME (1-442): 9.23e-128: 378: 100.00
+	Hs
		276928 CHMP5_HUMAN (1-203): 2.24e-36: 129: 19.05		VPS4B_HUMAN (2-442): 1.93e-125: 372: 74.21
+	Hs
		221889 CHM2A_HUMAN (1-190): 1.62e-41: 143: 77.90		SPAST_HUMAN (62-440): 3.55e-114: 349: 36.84
+	At
		1456765 VPS2A_ARATH (1-255): 5.86e-47: 157: 45.49		VPS4_ARATH (4-442): 3.62e-106: 323: 52.24
+	At
		102955 F4JXR3_ARATH (1-229): 1.13e-44: 153: 14.55		VPS4_ARATH (4-442): 3.62e-106: 323: 52.24
+	Sc
		781329 DID4_YEAST (2-256): 6.38e-41: 142: 39.45		VPS4_YEAST (1-442): 1.17e-110: 334: 57.21
+	At
		1442474 VP601_ARATH (1-229): 2.4e-42: 146: 16.46		VPS4_ARATH (4-442): 3.62e-106: 323: 52.24
+	At
		1082322 VPS2B_ARATH (3-213): 2.37e-38: 135: 31.82		VPS4_ARATH (4-442): 3.62e-106: 323: 52.24
+	At
		1457066 CHM1B_ARATH (13-215): 2.53e-34: 124: 21.18		VPS4_ARATH (4-442): 3.62e-106: 323: 52.24
+	Dm
		1301207 Q95SH2_DROME (14-215): 1.39e-34: 124: 26.73		SPAST_DROME (111-354): 2.57e-62: 216: 49.19