HitPredict

Interactor 1: SH2B2 (O14492)
SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS)
Gene: SH2B2

Interactor 2: LTK (P29376)
Leukocyte tyrosine kinase receptor (EC 2.7.10.1) (Protein tyrosine kinase 1)
Gene: LTK

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 632 Hs			1 864
+	Hs
		154427 SH2B2_HUMAN (22-632): 6.02e-162: 479: 100.00		ERBB4_HUMAN (277-846): 5.55e-131: 425: 21.41
+	Mm
		1223372 SH2B2_MOUSE (1-632): 5.3e-152: 454: 80.19		FGFR3_MOUSE (75-788): 7.62e-140: 436: 20.78
+	Hs
		154414 SH2B2_HUMAN (22-632): 6.02e-162: 479: 100.00		INSR_HUMAN (367-837): 3.31e-121: 400: 30.82
+	Mm
		581968 SH2B2_MOUSE (1-632): 5.3e-152: 454: 80.19		INSR_MOUSE (380-799): 1.79e-109: 368: 32.31
+	Hs
		650438 SH2B1_HUMAN (1-631): 2.41e-99: 321: 33.90		FGFR3_HUMAN (100-834): 2.09e-138: 432: 20.89
+	Hs
		1145787 SH2B1_HUMAN (1-631): 2.41e-99: 321: 33.90		ERBB4_HUMAN (277-846): 5.55e-131: 425: 21.41
+	Hs
		465662 SH2B1_HUMAN (1-631): 2.41e-99: 321: 33.90		IGF1R_HUMAN (298-854): 3.96e-128: 419: 27.39
+	Hs
		1145795 SH2B3_HUMAN (23-630): 4.43e-97: 310: 29.19		ERBB4_HUMAN (277-846): 5.55e-131: 425: 21.41
+	Hs
		463962 GRB7_HUMAN (4-511): 6.68e-80: 264: 13.96		RET_HUMAN (278-849): 1.23e-145: 460: 25.98
+	Hs
		439857 SH2B1_HUMAN (1-631): 2.41e-99: 321: 33.90		INSR_HUMAN (367-837): 3.31e-121: 400: 30.82
+	Hs
		154413 SH2B2_HUMAN (22-632): 6.02e-162: 479: 100.00		NTRK1_HUMAN (502-786): 7.78e-60: 220: 41.64
+	Hs
		1126610 GRB7_HUMAN (4-511): 6.68e-80: 264: 13.96		ERBB4_HUMAN (277-846): 5.55e-131: 425: 21.41
+	Hs
		932033 GRB7_HUMAN (4-511): 6.68e-80: 264: 13.96		EPHB1_HUMAN (390-816): 4.65e-128: 410: 25.17
+	Hs
		439731 GRB7_HUMAN (4-511): 6.68e-80: 264: 13.96		INSR_HUMAN (367-837): 3.31e-121: 400: 30.82
+	Mm
		757449 GRB7_MOUSE (4-511): 3.39e-89: 288: 13.96		FAK1_MOUSE (453-859): 4.95e-110: 363: 28.67
+	Rn
		776779 SH2B1_RAT (1-631): 1.43e-103: 332: 32.85		NTRK1_RAT (502-784): 2.43e-60: 221: 41.24
+	Hs
		1159549 SH2B1_HUMAN (1-631): 2.41e-99: 321: 33.90		NTRK2_HUMAN (475-778): 2.44e-61: 224: 38.07
+	Hs
		412664 SH2B1_HUMAN (1-631): 2.41e-99: 321: 33.90		NTRK1_HUMAN (502-786): 7.78e-60: 220: 41.64
+	Dm
		479720 Q7K137_DROME (22-527): 4.93e-80: 269: 28.20		INSR_DROME (457-778): 1.89e-68: 250: 37.69
+	Rn
		776773 SH2B3_RAT (386-630): 2.07e-69: 231: 33.57		NTRK1_RAT (502-784): 2.43e-60: 221: 41.24