HitPredict

Interactor 1: SOCS6 (O14544)
Suppressor of cytokine signaling 6 (SOCS-6) (Cytokine-inducible SH2 protein 4) (CIS-4) (Suppressor of cytokine signaling 4) (SOCS-4)
Gene: SOCS6

Interactor 2: ERN1 (O75460)
Serine/threonine-protein kinase/endoribonuclease IRE1 (Endoplasmic reticulum-to-nucleus signaling 1) (Inositol-requiring protein 1) (hIRE1p) (Ire1-alpha) (IRE1a) [Includes: Serine/threonine-protein kinase (EC 2.7.11.1); Endoribonuclease (EC 3.1.26.-)]
Gene: ERN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	32814053
Identification Methods	two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 535 Hs			1 977
+	Hs
		440039 LCK_HUMAN (258-495): 2.35e-55: 195: 17.20		KPCT_HUMAN (322-898): 7.48e-134: 421: 16.69
+	Hs
		440501 FYN_HUMAN (321-506): 1.75e-51: 185: 15.39		KPCT_HUMAN (322-898): 7.48e-134: 421: 16.69
+	Mm
		1034938 CISH_MOUSE (321-535): 1.26e-42: 154: 24.69		KPCT_MOUSE (322-895): 2.21e-133: 419: 16.69
+	Hs
		463263 YES_HUMAN (321-495): 5.01e-51: 185: 14.67		KCC2A_HUMAN (569-969): 2.37e-117: 369: 20.20
+	Mm
		686957 P85A_MOUSE (384-496): 1.31e-12: 72.4: 23.89		KPCT_MOUSE (322-895): 2.21e-133: 419: 16.69
+	Hs
		902836 BLK_HUMAN (301-495): 1.88e-47: 174: 16.13		KCC1A_HUMAN (571-851): 1.2e-88: 290: 27.49
+	Hs
		699900 P85A_HUMAN (384-496): 1.31e-12: 72.4: 23.89		KCC2A_HUMAN (569-969): 2.37e-117: 369: 20.20
+	Hs
		440568 FYN_HUMAN (321-506): 1.75e-51: 185: 15.39		KS6A2_HUMAN (570-873): 1.04e-67: 243: 22.26
+	Hs
		463100 YES_HUMAN (321-495): 5.01e-51: 185: 14.67		KS6A2_HUMAN (570-873): 1.04e-67: 243: 22.26
+	Hs
		440452 FYN_HUMAN (321-506): 1.75e-51: 185: 15.39		KS6A3_HUMAN (570-873): 3.7e-66: 238: 20.69
+	Hs
		557185 SRC_HUMAN (258-495): 1.88e-51: 185: 15.32		KS6A3_HUMAN (570-873): 3.7e-66: 238: 20.69
+	Hs
		841011 FRK_HUMAN (321-506): 2.07e-54: 193: 18.46		KS6A1_HUMAN (570-873): 6.37e-63: 229: 20.38
+	Hs
		440570 FYN_HUMAN (321-506): 1.75e-51: 185: 15.39		KS6A1_HUMAN (570-873): 6.37e-63: 229: 20.38
+	Hs
		1120033 P55G_HUMAN (380-505): 2.86e-19: 92.5: 26.19		KCC1A_HUMAN (571-851): 1.2e-88: 290: 27.49
+	Hs
		136390 P85B_HUMAN (380-491): 1.9e-14: 78.2: 27.68		KS6A2_HUMAN (570-873): 1.04e-67: 243: 22.26
+	Hs
		699759 P85A_HUMAN (384-496): 1.31e-12: 72.4: 23.89		KS6A2_HUMAN (570-873): 1.04e-67: 243: 22.26
+	Hs
		699657 P85A_HUMAN (384-496): 1.31e-12: 72.4: 23.89		KS6A3_HUMAN (570-873): 3.7e-66: 238: 20.69
+	Ce
		234030 SRC2_CAEEL (254-499): 8.06e-53: 188: 18.55		KCC2D_CAEEL (591-851): 4.55e-20: 97.8: 27.84
+	Hs
		463088 YES_HUMAN (321-495): 5.01e-51: 185: 14.67		KCC2G_HUMAN (610-831): 3.26e-18: 91.3: 29.31
+	Ce
		112315 SRC1_CAEEL (318-506): 6.45e-44: 165: 15.00		KCC2D_CAEEL (591-851): 4.55e-20: 97.8: 27.84