Protein: MTF2
Metal-response element-binding transcription factor 2 (Metal regulatory transcription factor 2) (Metal-response element DNA-binding protein M96) (Polycomb-like protein 2) (hPCl2)

Gene: MTF2
Organism: Homo sapiens
Interactions: 92
UniProt ID: Q9Y483

Gene Ontology (top 5):
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0001222 - transcription corepressor binding
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1369256

JARD2
Protein Jumonji

3

9

Small-scale

0.847

High

1155942

EZH2
Histone-lysine N-methyltransferase EZH2

10

20

Small-scale

0.755

High

1137606

SUZ12
Polycomb protein SUZ12

7

6

Small-scale

0.749

High

1159060

RBBP7
Histone-binding protein RBBP7

6

14

High-throughput

0.735

High

1066557

RBBP4
Histone-binding protein RBBP4

4

14

High-throughput

0.697

High

1163310

H2B2E
Histone H2B type 2-E

1

6

High-throughput

0.691

High

285539

EED
Polycomb protein EED

3

13

High-throughput

0.675

High

1368814

EZH1
Histone-lysine N-methyltransferase EZH1

3

20

High-throughput

0.675

High

216570

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

8

High-throughput

0.656

High

1434607

SUV92
Histone-lysine N-methyltransferase SUV39H2

1

4

High-throughput

0.656

High

1096287

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.630

High

1395320

LCOR
Ligand-dependent corepressor

2

2

High-throughput

0.628

High

210368

PHF1
PHD finger protein 1

1

10

High-throughput

0.618

High

317051

MTA2
Metastasis-associated protein MTA2

1

9

High-throughput

0.618

High

883742

CENPA
Histone H3-like centromeric protein A

1

9

High-throughput

0.618

High

981196

H2B1C
Histone H2B type 1-C/E/F/G/I

1

6

High-throughput

0.618

High

998998

H31
Histone H3.1

1

9

High-throughput

0.618

High

1086838

BPTF
Nucleosome-remodeling factor subunit BPTF

1

10

High-throughput

0.618

High

1088639

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

9

High-throughput

0.618

High

1102693

MTA1
Metastasis-associated protein MTA1

1

9

High-throughput

0.618

High

1133070

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

9

High-throughput

0.618

High

1195619

ARI4B
AT-rich interactive domain-containing protein 4B

1

4

High-throughput

0.618

High

1213601

PHF19
PHD finger protein 19

1

10

High-throughput

0.618

High

1368223

HDAC2
Histone deacetylase 2

1

4

High-throughput

0.618

High

1403058

SIN3A
Paired amphipathic helix protein Sin3a

1

2

High-throughput

0.618

High

1413369

MTA3
Metastasis-associated protein MTA3

1

9

High-throughput

0.618

High

65643

EPOP
Elongin BC and Polycomb repressive complex 2-associated protein

2

9

High-throughput

0.611

High

937516

CDN2D
Cyclin-dependent kinase 4 inhibitor D

2

2

High-throughput

0.606

High

243382

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.575

High

122881

KIF2A
Kinesin-like protein KIF2A

1

1

High-throughput

0.536

High

601917

HMGA1
High mobility group protein HMG-I/HMG-Y

1

1

High-throughput

0.536

High

1134777

NUMA1
Nuclear mitotic apparatus protein 1

1

2

High-throughput

0.536

High

1431079

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

1

High-throughput

0.536

High

1364901

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

2

High-throughput

0.526

High

593250

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.518

High

570642

GFAP
Glial fibrillary acidic protein

1

1

High-throughput

0.515

High

1013124

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

1388669

SPDLY
Protein Spindly

1

0

High-throughput

0.513

High

1461074

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

0

High-throughput

0.513

High

247052

KDM1A
Lysine-specific histone demethylase 1A

1

7

High-throughput

0.508

High

1014674

SMAD3
Mothers against decapentaplegic homolog 3

1

3

High-throughput

0.508

High

1396949

ANM6
Protein arginine N-methyltransferase 6

1

2

High-throughput

0.508

High

1420085

KPCD2
Serine/threonine-protein kinase D2

1

1

High-throughput

0.508

High

791868

SYUA
Alpha-synuclein

1

0

High-throughput

0.493

High

927184

ATX3
Ataxin-3

1

0

High-throughput

0.493

High

1199414

GLE1
mRNA export factor GLE1

1

0

High-throughput

0.493

High

1279810

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.493

High

1451668

DDIT4
DNA damage-inducible transcript 4 protein

1

0

High-throughput

0.493

High

911962

JAK3
Tyrosine-protein kinase JAK3

1

2

High-throughput

0.489

High

1169540

SKDA1
SKI/DACH domain-containing protein 1

1

5

High-throughput

0.489

High

891909

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.486

High

155374

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

1

High-throughput

0.479

High

243774

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

9

High-throughput

0.479

High

282330

SAP30
Histone deacetylase complex subunit SAP30

1

1

High-throughput

0.479

High

352274

MBD3
Methyl-CpG-binding domain protein 3

1

3

High-throughput

0.479

High

487917

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.479

High

519581

MYBB
Myb-related protein B

1

3

High-throughput

0.479

High

703400

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

9

High-throughput

0.479

High

980595

H4
Histone H4

1

4

High-throughput

0.479

High

1135287

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

14

High-throughput

0.479

High

1208660

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

3

High-throughput

0.479

High

1216642

LIN9
Protein lin-9 homolog

1

1

High-throughput

0.479

High

1252574

AEBP2
Zinc finger protein AEBP2

1

5

High-throughput

0.479

High

1295331

P66A
Transcriptional repressor p66-alpha

1

3

High-throughput

0.479

High

1312704

BAP18
BPTF-associated chromatin complex component 1

1

1

High-throughput

0.479

High

1329030

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

1

High-throughput

0.479

High

1335475

HJURP
Holliday junction recognition protein

1

1

High-throughput

0.479

High

1357175

GATD1
GATA zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

1361044

P66B
Transcriptional repressor p66-beta

1

3

High-throughput

0.479

High

1392578

LIN37
Protein lin-37 homolog

1

1

High-throughput

0.479

High

1396156

Z512B
Zinc finger protein 512B

1

3

High-throughput

0.479

High

1398777

PWP2A
PWWP domain-containing protein 2A

1

3

High-throughput

0.479

High

1405584

TBX5
T-box transcription factor TBX5

1

2

High-throughput

0.479

High

1429924

SP130
Histone deacetylase complex subunit SAP130

1

6

High-throughput

0.479

High

1430831

BC11A
BCL11 transcription factor A

1

1

High-throughput

0.479

High

1435870

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

3

High-throughput

0.479

High

1458216

MBD2
Methyl-CpG-binding domain protein 2

1

3

High-throughput

0.479

High

1459432

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1459659

HMGX4
HMG domain-containing protein 4

1

4

High-throughput

0.479

High

109538

G5E9A7
DM1 locus, WD repeat containing

1

9

High-throughput

0.470

High

1360781

JPH3
Junctophilin-3

1

1

High-throughput

0.470

High

1387312

RMD1
Regulator of microtubule dynamics protein 1

1

0

High-throughput

0.458

High

1491276

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

1057065

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.457

High

1404537

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.457

High

138541

BIN1
Myc box-dependent-interacting protein 1

1

0

High-throughput

0.438

High

1237988

Q6NSK7
RIN3 protein

1

2

High-throughput

0.417

High

1448589

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.417

High

337424

TGDS
dTDP-D-glucose 4,6-dehydratase

2

0

High-throughput

0.328

High

1415436

TMED9
Transmembrane emp24 domain-containing protein 9

1

0

High-throughput

0.282

High

1384617

Q96BH6
LAMC1 protein

1

0

High-throughput

0.268

Low

1383636

VOPP1
WW domain binding protein VOPP1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025