Protein: PHF1
PHD finger protein 1 (Protein PHF1) (hPHF1) (Polycomb-like protein 1) (hPCl1)

Gene: PHF1
Organism: Homo sapiens
Interactions: 164
UniProt ID: O43189

Gene Ontology (top 5):
GO:0001222 - transcription corepressor binding
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

210325

RBPMS
RNA-binding protein with multiple splicing

4

0

High-throughput

0.864

High

210294

PHF19
PHD finger protein 19

2

10

High-throughput

0.789

High

210259

ARI5A
AT-rich interactive domain-containing protein 5A

2

7

High-throughput

0.783

High

210320

DPF1
Zinc finger protein neuro-d4

2

13

High-throughput

0.783

High

210256

H31
Histone H3.1

2

9

Small-scale

0.778

High

210284

EZH2
Histone-lysine N-methyltransferase EZH2

16

20

Small-scale

0.763

High

210287

H31T
Histone H3.1t

1

9

Small-scale

0.757

High

210281

SUZ12
Polycomb protein SUZ12

11

6

Small-scale

0.757

High

210230

MTA2
Metastasis-associated protein MTA2

2

9

Small-scale

0.754

High

210272

MTA1
Metastasis-associated protein MTA1

2

9

Small-scale

0.754

High

210273

HDAC1
Histone deacetylase 1

2

4

Small-scale

0.754

High

210289

ARI4B
AT-rich interactive domain-containing protein 4B

2

4

Small-scale

0.754

High

210319

HDAC2
Histone deacetylase 2

2

4

Small-scale

0.754

High

210335

SIN3A
Paired amphipathic helix protein Sin3a

2

2

Small-scale

0.754

High

210343

MTA3
Metastasis-associated protein MTA3

2

9

Small-scale

0.754

High

210225

EED
Polycomb protein EED

8

13

Small-scale

0.750

High

210286

RBBP7
Histone-binding protein RBBP7

7

14

Small-scale

0.745

High

210321

EZH1
Histone-lysine N-methyltransferase EZH1

5

20

Small-scale

0.716

High

210266

RBBP4
Histone-binding protein RBBP4

5

14

Small-scale

0.712

High

210340

DHB14
L-fucose dehydrogenase

4

1

High-throughput

0.698

High

210233

P53
Cellular tumor antigen p53

4

2

Small-scale

0.694

High

210283

NAB2
NGFI-A-binding protein 2

4

0

High-throughput

0.668

High

210356

THAP1
THAP domain-containing protein 1

3

3

High-throughput

0.667

High

65622

EPOP
Elongin BC and Polycomb repressive complex 2-associated protein

3

9

High-throughput

0.667

High

210330

LCOR
Ligand-dependent corepressor

3

2

High-throughput

0.667

High

210328

ZBT10
Zinc finger and BTB domain-containing protein 10

3

2

High-throughput

0.665

High

210311

BOLL
Protein boule-like

2

0

High-throughput

0.655

High

210268

TFCP2
Alpha-globin transcription factor CP2

2

2

High-throughput

0.640

High

210354

PDLI7
PDZ and LIM domain protein 7

2

1

High-throughput

0.628

High

210285

DDB1
DNA damage-binding protein 1

2

1

Small-scale

0.619

High

210217

PHF1
PHD finger protein 1

1

10

Small-scale

0.618

High

210269

BPTF
Nucleosome-remodeling factor subunit BPTF

1

10

High-throughput

0.618

High

210270

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

9

High-throughput

0.618

High

210279

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

9

High-throughput

0.618

High

210322

JARD2
Protein Jumonji

1

9

High-throughput

0.618

High

210368

MTF2
Metal-response element-binding transcription factor 2

1

10

High-throughput

0.618

High

210219

ZN500
Zinc finger protein 500

2

1

High-throughput

0.606

High

210235

ZN688
Zinc finger protein 688

2

1

High-throughput

0.606

High

210251

LBX1
Transcription factor LBX1

2

4

High-throughput

0.606

High

210252

FOSB
Protein FosB

2

2

High-throughput

0.606

High

210260

ZBT16
Zinc finger and BTB domain-containing protein 16

2

1

High-throughput

0.606

High

210276

FHL2
Four and a half LIM domains protein 2

2

4

High-throughput

0.606

High

210297

TENS2
Tensin-2

2

3

High-throughput

0.606

High

210298

K1C40
Keratin, type I cytoskeletal 40

2

1

High-throughput

0.606

High

210300

MORN3
MORN repeat-containing protein 3

2

1

High-throughput

0.606

High

210334

TOX2
TOX high mobility group box family member 2

2

1

High-throughput

0.606

High

210342

LZTS2
Leucine zipper putative tumor suppressor 2

2

2

High-throughput

0.606

High

210350

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

2

1

High-throughput

0.606

High

210355

DISC1
Disrupted in schizophrenia 1 protein

2

1

High-throughput

0.606

High

210362

ZRAN1
Ubiquitin thioesterase ZRANB1

2

3

High-throughput

0.606

High

210370

MAGD1
Melanoma-associated antigen D1

2

1

High-throughput

0.606

High

210246

TRI23
E3 ubiquitin-protein ligase TRIM23

2

0

High-throughput

0.601

High

210327

BIRC7
Baculoviral IAP repeat-containing protein 7

2

0

High-throughput

0.601

High

210224

SAP30
Histone deacetylase complex subunit SAP30

2

1

Small-scale

0.584

High

154918

BHE40
Class E basic helix-loop-helix protein 40

2

0

High-throughput

0.580

High

210221

VINEX
Vinexin

2

0

High-throughput

0.580

High

210263

TLE5
TLE family member 5

2

0

High-throughput

0.580

High

210267

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

210296

IKBP1
Interleukin-1 receptor-associated kinase 1-binding protein 1

2

0

High-throughput

0.580

High

210302

GASP3
G protein-coupled receptor associated sorting protein 3

2

0

High-throughput

0.580

High

210315

ZN526
Zinc finger protein 526

2

0

High-throughput

0.580

High

210324

GPKOW
G-patch domain and KOW motifs-containing protein

2

0

High-throughput

0.580

High

210336

PFD5
Prefoldin subunit 5

2

0

High-throughput

0.580

High

210337

MDFI
MyoD family inhibitor

2

0

High-throughput

0.580

High

210339

SPAG8
Sperm-associated antigen 8

2

0

High-throughput

0.580

High

210345

SMG9
Nonsense-mediated mRNA decay factor SMG9

2

0

High-throughput

0.580

High

210353

ZNF71
Endothelial zinc finger protein induced by tumor necrosis factor alpha

2

0

High-throughput

0.580

High

210358

ABI2
Abl interactor 2

2

0

High-throughput

0.580

High

210359

ZIM2
Zinc finger imprinted 2

2

0

High-throughput

0.580

High

210361

TFP11
Tuftelin-interacting protein 11

2

0

High-throughput

0.580

High

210331

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

2

0

High-throughput

0.576

High

210265

VAC14
Protein VAC14 homolog

1

1

High-throughput

0.573

High

210274

CUL4B
Cullin-4B

2

2

Small-scale

0.571

High

162395

ANM5
Protein arginine N-methyltransferase 5

1

2

Small-scale

0.561

High

210254

H4
Histone H4

1

4

Small-scale

0.561

High

210326

ARRD3
Arrestin domain-containing protein 3

2

1

High-throughput

0.553

High

210277

HIC1
Hypermethylated in cancer 1 protein

1

2

Small-scale

0.552

High

210271

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.549

High

210222

DJC13
DnaJ homolog subfamily C member 13

1

1

High-throughput

0.536

High

210226

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

6

High-throughput

0.536

High

210248

TCPQ
T-complex protein 1 subunit theta

1

1

High-throughput

0.536

High

210250

ZN131
Zinc finger protein 131

1

1

High-throughput

0.536

High

210366

DICER
Endoribonuclease Dicer

1

1

High-throughput

0.536

High

210365

AT7L1
Ataxin-7-like protein 1

1

4

High-throughput

0.523

High

210261

Q05BL1
TP53BP2 protein

1

3

High-throughput

0.515

High

210299

Q6FHY5
MEOX2 protein

1

3

High-throughput

0.515

High

210241

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.513

High

210245

DEK
Protein DEK

1

0

High-throughput

0.513

High

210282

TRBP2
RISC-loading complex subunit TARBP2

1

0

High-throughput

0.513

High

210301

BORA
Protein aurora borealis

1

0

High-throughput

0.513

High

210351

NEK6
Serine/threonine-protein kinase Nek6

1

0

Small-scale

0.504

High

210257

PR20D
Proline-rich protein 20D

1

1

High-throughput

0.483

High

210247

MEOX2
Homeobox protein MOX-2

1

3

High-throughput

0.481

High

210275

ASPP2
Apoptosis-stimulating of p53 protein 2

1

3

High-throughput

0.481

High

210309

HOMEZ
Homeobox and leucine zipper protein Homez

1

5

High-throughput

0.481

High

210318

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.481

High

210357

ZSC32
Zinc finger and SCAN domain-containing protein 32

1

1

High-throughput

0.481

High

155261

CDKA1
Cyclin-dependent kinase 2-associated protein 1

1

1

High-throughput

0.479

High

210218

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

9

High-throughput

0.479

High

210220

KDM1A
Lysine-specific histone demethylase 1A

1

3

Small-scale

0.479

High

210231

MBD3
Methyl-CpG-binding domain protein 3

1

3

High-throughput

0.479

High

210236

MYBB
Myb-related protein B

1

3

High-throughput

0.479

High

210237

SRC
Proto-oncogene tyrosine-protein kinase Src

1

1

Small-scale

0.479

High

210238

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.479

High

210239

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.479

High

210243

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

9

High-throughput

0.479

High

210262

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

Small-scale

0.479

High

210264

DHX9
ATP-dependent RNA helicase A

1

1

Small-scale

0.479

High

210280

SHPRH
E3 ubiquitin-protein ligase SHPRH

1

13

High-throughput

0.479

High

210292

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

3

High-throughput

0.479

High

210295

LIN9
Protein lin-9 homolog

1

1

High-throughput

0.479

High

210303

AEBP2
Zinc finger protein AEBP2

1

5

High-throughput

0.479

High

210304

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

210308

P66A
Transcriptional repressor p66-alpha

1

3

High-throughput

0.479

High

210310

BAP18
BPTF-associated chromatin complex component 1

1

1

High-throughput

0.479

High

210314

HJURP
Holliday junction recognition protein

1

1

High-throughput

0.479

High

210316

GATD1
GATA zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

210317

P66B
Transcriptional repressor p66-beta

1

3

High-throughput

0.479

High

210323

RAD50
DNA repair protein RAD50

1

2

Small-scale

0.479

High

210329

LIN37
Protein lin-37 homolog

1

1

High-throughput

0.479

High

210332

Z512B
Zinc finger protein 512B

1

3

High-throughput

0.479

High

210333

PWP2A
PWWP domain-containing protein 2A

1

3

High-throughput

0.479

High

210341

MEP50
Methylosome protein WDR77

1

7

Small-scale

0.479

High

210344

SP130
Histone deacetylase complex subunit SAP130

1

6

High-throughput

0.479

High

210346

BC11A
BCL11 transcription factor A

1

1

High-throughput

0.479

High

210349

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

3

High-throughput

0.479

High

210352

EXOS4
Exosome complex component RRP41

1

1

High-throughput

0.479

High

210360

MBD2
Methyl-CpG-binding domain protein 2

1

3

High-throughput

0.479

High

210363

HMGX4
HMG domain-containing protein 4

1

4

High-throughput

0.479

High

210364

LIMA1
LIM domain and actin-binding protein 1

1

1

Small-scale

0.479

High

210372

NCOA3
Nuclear receptor coactivator 3

1

2

Small-scale

0.479

High

210288

Q4G0R1
PIBF1 protein

1

1

High-throughput

0.470

High

168154

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.458

High

210223

ZN217
Zinc finger protein 217

1

0

Small-scale

0.458

High

210240

DDX5
Probable ATP-dependent RNA helicase DDX5

1

0

Small-scale

0.458

High

210244

HSP74
Heat shock 70 kDa protein 4

1

0

Small-scale

0.458

High

210253

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

Small-scale

0.458

High

210255

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

210278

SMC1A
Structural maintenance of chromosomes protein 1A

1

0

Small-scale

0.458

High

210290

LIN52
Protein lin-52 homolog

1

0

High-throughput

0.458

High

210348

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

210367

GRIP1
Glutamate receptor-interacting protein 1

1

0

Small-scale

0.458

High

210258

PR20A
Proline-rich protein 20A

1

1

High-throughput

0.439

High

210234

CALCA
Calcitonin gene-related peptide 1

1

1

High-throughput

0.437

High

210249

AFF2
AF4/FMR2 family member 2

1

3

Small-scale

0.437

High

210228

GLRX3
Glutaredoxin-3

1

0

High-throughput

0.426

High

210232

CALC
Calcitonin [Cleaved into: Calcitonin

1

1

High-throughput

0.407

High

210307

PRSR2
Proline and serine-rich protein 2

2

0

High-throughput

0.328

High

210305

K0408
Uncharacterized protein KIAA0408

2

0

High-throughput

0.320

High

64986

GG6L9
Golgin subfamily A member 6-like protein 9

2

0

High-throughput

0.316

High

210291

EFHC2
EF-hand domain-containing family member C2

2

0

High-throughput

0.316

High

210293

AVPI1
Arginine vasopressin-induced protein 1

2

0

High-throughput

0.316

High

210306

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

2

0

High-throughput

0.316

High

210313

RB8NL
RBBP8 N-terminal-like protein

2

0

High-throughput

0.316

High

210347

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

2

0

High-throughput

0.316

High

210227

DYSF
Dysferlin

1

0

High-throughput

0.282

High

210312

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

1

0

High-throughput

0.279

Low

210338

MIPEP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.279

Low

210369

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.279

Low

210371

S4A7
Sodium bicarbonate cotransporter 3

1

0

High-throughput

0.279

Low

104876

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

210229

NCTR1
Natural cytotoxicity triggering receptor 1

1

0

Small-scale

0.249

Low

210242

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025