HitPredict

Interactor 1: NHRF1 (O14745)
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF-1) (Ezrin-radixin-moesin-binding phosphoprotein 50) (EBP50) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory factor 1)
Gene: NHERF1

Interactor 2: EPHA7 (Q15375)
Ephrin type-A receptor 7 (EC 2.7.10.1) (EPH homology kinase 3) (EHK-3) (EPH-like kinase 11) (EK11) (hEK11)
Gene: EPHA7

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~fn3, PDZ~SAM_1
Common GO terms	GO:0051898 - negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 358 Hs			1 998
+	Hs
		162812 NHRF1_HUMAN (1-358): 9.87e-82: 254: 100.00		EPHB1_HUMAN (32-991): 0: 1191: 56.57
+	Hs
		1122235 SCRIB_HUMAN (7-337): 2.53e-29: 121: 19.83		EPHA7_HUMAN (1-998): 0: 1312: 100.00
+	Hs
		1147375 LNX2_HUMAN (4-348): 1.25e-26: 113: 13.80		EPHA7_HUMAN (1-998): 0: 1312: 100.00
+	Hs
		1091501 DLG1_HUMAN (55-238): 6.78e-12: 68.9: 18.85		EPHA7_HUMAN (1-998): 0: 1312: 100.00
+	Hs
		710831 SCRIB_HUMAN (7-337): 2.53e-29: 121: 19.83		EPHB2_HUMAN (32-995): 0: 1192: 57.51
+	Hs
		932062 DLG1_HUMAN (55-238): 6.78e-12: 68.9: 18.85		EPHA4_HUMAN (4-998): 0: 1233: 62.29
+	Hs
		931842 DLG1_HUMAN (55-238): 6.78e-12: 68.9: 18.85		EPHA5_HUMAN (6-988): 0: 1209: 62.74
+	Hs
		931840 PTN13_HUMAN (71-232): 1.98e-11: 67.7: 13.33		EPHA5_HUMAN (6-988): 0: 1209: 62.74
+	Hs
		710622 PTN13_HUMAN (71-232): 1.98e-11: 67.7: 13.33		EPHA3_HUMAN (25-990): 0: 1206: 62.01
+	Hs
		710820 PTN13_HUMAN (71-232): 1.98e-11: 67.7: 13.33		EPHB2_HUMAN (32-995): 0: 1192: 57.51
+	Hs
		710232 SNTB1_HUMAN (5-347): 1.02e-40: 152: 16.07		EPHA2_HUMAN (29-998): 0: 1085: 50.36
+	Hs
		710408 DLG3_HUMAN (14-292): 1.13e-29: 122: 14.24		EPHA2_HUMAN (29-998): 0: 1085: 50.36
+	Hs
		710238 SCRIB_HUMAN (7-337): 2.53e-29: 121: 19.83		EPHA2_HUMAN (29-998): 0: 1085: 50.36
+	Hs
		710208 DLG1_HUMAN (55-238): 6.78e-12: 68.9: 18.85		EPHA2_HUMAN (29-998): 0: 1085: 50.36
+	Hs
		710205 PTN13_HUMAN (71-232): 1.98e-11: 67.7: 13.33		EPHA2_HUMAN (29-998): 0: 1085: 50.36
+	Hs
		640158 PTN13_HUMAN (71-232): 1.98e-11: 67.7: 13.33		EPHA1_HUMAN (10-986): 0: 981: 44.30
+	Hs
		162791 NHRF1_HUMAN (1-358): 9.87e-82: 254: 100.00		UFO_HUMAN (271-950): 5.78e-148: 464: 22.27
+	Hs
		720218 SCRIB_HUMAN (7-337): 2.53e-29: 121: 19.83		UFO_HUMAN (271-950): 5.78e-148: 464: 22.27
+	Hs
		720208 DLG1_HUMAN (55-238): 6.78e-12: 68.9: 18.85		UFO_HUMAN (271-950): 5.78e-148: 464: 22.27
+	Hs
		440486 DLG4_HUMAN (88-235): 2.26e-13: 73.1: 19.36		FYN_HUMAN (627-891): 1.3e-62: 224: 43.45