HitPredict

Interactor 1: ML12B (O14950)
Myosin regulatory light chain 12B (MLC-2A) (MLC-2) (Myosin regulatory light chain 2-B, smooth muscle isoform) (Myosin regulatory light chain 20 kDa) (MLC20) (Myosin regulatory light chain MRLC2) (SHUJUN-1)
Gene: MYL12B

Interactor 2: MY18B (Q8IUG5)
Unconventional myosin-XVIIIb
Gene: MYO18B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	EF-hand_7~Myosin_head
Common GO terms	GO:0005737 - cytoplasm GO:0016460 - myosin II complex GO:0030018 - Z disc
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 172 Hs			1 2567
+	Hs
		169065 ML12B_HUMAN (1-172): 1.28e-67: 204: 100.00		MYH10_HUMAN (1267-2333): 7.11e-61: 235: 14.35
+	Hs
		666741 MYL9_HUMAN (1-172): 2.2e-66: 201: 93.02		MYH10_HUMAN (1267-2333): 7.11e-61: 235: 14.35
+	Hs
		618654 ML12A_HUMAN (15-172): 1.81e-65: 199: 99.37		MYH10_HUMAN (1267-2333): 7.11e-61: 235: 14.35
+	Hs
		169066 ML12B_HUMAN (1-172): 1.28e-67: 204: 100.00		MYH11_HUMAN (1278-2268): 3.43e-58: 226: 13.34
+	Hs
		169064 ML12B_HUMAN (1-172): 1.28e-67: 204: 100.00		MYH9_HUMAN (1492-2547): 4.4e-57: 222: 11.92
+	Hs
		618655 ML12A_HUMAN (15-172): 1.81e-65: 199: 99.37		MYH11_HUMAN (1278-2268): 3.43e-58: 226: 13.34
+	Hs
		666740 MYL9_HUMAN (1-172): 2.2e-66: 201: 93.02		MYH9_HUMAN (1492-2547): 4.4e-57: 222: 11.92
+	Hs
		618653 ML12A_HUMAN (15-172): 1.81e-65: 199: 99.37		MYH9_HUMAN (1492-2547): 4.4e-57: 222: 11.92
+	Mm
		1223376 Q6ZWQ9_MOUSE (1-172): 7.04e-67: 203: 97.67		MYH10_MOUSE (1696-2558): 1.85e-46: 187: 14.17
+	Hs
		169045 ML12B_HUMAN (1-172): 1.28e-67: 204: 100.00		MYH7_HUMAN (1846-2567): 1.5e-44: 181: 11.35
+	Hs
		169126 ML12B_HUMAN (1-172): 1.28e-67: 204: 100.00		MY18A_HUMAN (1978-2567): 1.88e-34: 148: 10.23
+	Hs
		618717 ML12A_HUMAN (15-172): 1.81e-65: 199: 99.37		MY18A_HUMAN (1978-2567): 1.88e-34: 148: 10.23
+	Mm
		906631 MLRV_MOUSE (9-166): 3.71e-54: 170: 55.98		MYH6_MOUSE (1846-2567): 1.98e-39: 164: 10.91
+	Dm
		432167 MLR_DROME (13-163): 1.87e-29: 109: 42.21		MYSA_DROME (1602-2567): 5.02e-46: 186: 10.54
+	Hs
		169171 ML12B_HUMAN (1-172): 1.28e-67: 204: 100.00		MYO5A_HUMAN (2217-2539): 1.07e-15: 86.4: 10.95
+	Hs
		692660 CALL3_HUMAN (32-93): 7.09e-11: 59: 25.76		MYH9_HUMAN (1492-2547): 4.4e-57: 222: 11.92
+	Hs
		169165 ML12B_HUMAN (1-172): 1.28e-67: 204: 100.00		MYH15_HUMAN (1416-2058): 1.65e-11: 72.4: 19.85
+	Hs
		534006 MLRV_HUMAN (9-166): 1.99e-54: 171: 57.23		MYO5A_HUMAN (2217-2539): 1.07e-15: 86.4: 10.95
+	Dm
		823778 SQH_DROME (1-172): 1.45e-61: 189: 81.03		MYSN_DROME (1395-2090): 6.99e-10: 67.4: 18.71
+	Hs
		533985 MLRV_HUMAN (9-166): 1.99e-54: 171: 57.23		MYH1_HUMAN (2261-2567): 3.15e-10: 68.3: 9.45