HitPredict

Interactor 1: TIF1A (O15164)
Transcription intermediary factor 1-alpha (TIF1-alpha) (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRIM24) (RING finger protein 82) (RING-type E3 ubiquitin transferase TIF1-alpha) (Tripartite motif-containing protein 24)
Gene: TRIM24

Interactor 2: PML (P29590)
Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19)
Gene: PML

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.68 1.00 0.827

The method score is based on:

Property Details
Experiments 10610177, 34795231, 36880596
Identification Methods affinity chromatography technology, proximity labelling technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains zf-B_box~zf-B_box, zf-B_box~zf-C3HC4
Common GO terms GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0008270 - zinc ion binding
and 2 others

more...
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 1050
Hs

1 882
+ Hs
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Mm
+ Mm
+ Hs
+ Hs
+ Mm
+ Mm
+ Dr
+ Hs
+ Hs
+ Hs
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024