HitPredict

Interactor 1: ARHGB (O15085)
Rho guanine nucleotide exchange factor 11 (PDZ-RhoGEF)
Gene: ARHGEF11

Interactor 2: PLXB3 (Q9ULL4)
Plexin-B3
Gene: PLXNB3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.648

Property	Details
Experiments	12183458, 12123608, 12421765
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1522 Hs			1 1909
+	Mm
		1229348 Q68FM7_MOUSE (1-1522): 0: 908: 81.95		PLXB3_MOUSE (10-1909): 0: 2360: 84.14
+	Hs
		175280 ARHGB_HUMAN (1-1522): 0: 973: 100.00		PLXB2_HUMAN (42-1909): 0: 2003: 39.38
+	Mm
		74674 Q68FM7_MOUSE (1-1522): 0: 908: 81.95		PLXB2_MOUSE (42-1909): 0: 1986: 38.83
+	Hs
		175444 ARHGC_HUMAN (12-1457): 0: 627: 29.94		PLXB2_HUMAN (42-1909): 0: 2003: 39.38
+	Dm
		1071107 Q9U7D8_DROME (741-930): 2.83e-14: 80.5: 25.64		Q0KIF1_DROME (392-1905): 0: 1749: 33.33
+	Hs
		177348 ARHGB_HUMAN (1-1522): 0: 973: 100.00		PLXB1_HUMAN (22-694): 0: 610: 44.44
+	Mm
		1229347 Q68FM7_MOUSE (1-1522): 0: 908: 81.95		PLXB1_MOUSE (38-691): 0: 612: 43.63
+	Mm
		1298799 ARHGC_MOUSE (12-1457): 0: 635: 30.78		PLXB1_MOUSE (38-691): 0: 612: 43.63
+	Hs
		208139 ARHGC_HUMAN (12-1457): 0: 627: 29.94		PLXB1_HUMAN (22-694): 0: 610: 44.44
+	Mm
		107103 FARP1_MOUSE (222-1177): 8.66e-116: 393: 14.36		MET_MOUSE (48-548): 6.5e-77: 284: 20.14
+	Hs
		472143 VAV3_HUMAN (553-1281): 5.75e-120: 399: 15.46		MET_HUMAN (48-548): 3.76e-74: 275: 20.29
+	Hs
		472029 VAV2_HUMAN (553-1288): 5.54e-112: 378: 15.07		MET_HUMAN (48-548): 3.76e-74: 275: 20.29
+	Mm
		116258 H3BJU7_MOUSE (527-1423): 8.02e-104: 357: 17.34		MET_MOUSE (48-548): 6.5e-77: 284: 20.14
+	Mm
		591123 TRIO_MOUSE (188-1441): 1.42e-94: 341: 12.33		MET_MOUSE (48-548): 6.5e-77: 284: 20.14
+	Mm
		60070 KALRN_MOUSE (336-1168): 8.18e-78: 288: 12.78		MET_MOUSE (48-548): 6.5e-77: 284: 20.14
+	Mm
		104677 F6U8U1_MOUSE (735-891): 4.26e-13: 74.3: 30.00		MET_MOUSE (48-548): 6.5e-77: 284: 20.14
+	Dm
		57047 A1ZAN6_DROME (48-247): 2.77e-44: 179: 31.03		Q0E8S4_DROME (39-516): 7.33e-29: 128: 19.41
+	Dm
		57048 A1ZAN6_DROME (48-247): 2.77e-44: 179: 31.03		SEM1A_DROME (39-516): 7.24e-29: 128: 19.41
+	Dm
		1173655 Q9U7D8_DROME (741-930): 2.83e-14: 80.5: 25.64		SEM1A_DROME (39-516): 7.24e-29: 128: 19.41