HitPredict

Interactor 1: SH3G3 (O35180)
Endophilin-A3 (Endophilin-3) (SH3 domain protein 2C) (SH3 domain-containing GRB2-like protein 3) (SH3p13)
Gene: Sh3gl3

Interactor 2: DYN1 (P21575)
Dynamin-1 (EC 3.6.5.5) (B-dynamin) (D100) (Dynamin I) (Dynamin, brain)
Gene: Dnm1

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	9238017
Identification Methods	far western blotting, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0006897 - endocytosis GO:0098793 - presynapse GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 347 Rn			1 864
+	Mm
		810527 SH3G3_MOUSE (1-346): 1.21e-94: 287: 94.80		DYN1_MOUSE (1-848): 0: 1066: 98.00
+	Hs
		1050711 SH3G2_HUMAN (1-347): 2.69e-87: 268: 66.19		DYN1_HUMAN (1-864): 0: 1071: 98.03
+	Rn
		204407 SH3G2_RAT (1-347): 4.67e-87: 267: 65.06		DYN1_RAT (1-864): 0: 1066: 100.00
+	Mm
		810526 SH3G2_MOUSE (1-347): 4.48e-87: 267: 65.91		DYN1_MOUSE (1-848): 0: 1066: 98.00
+	Hs
		1050710 SH3G1_HUMAN (1-347): 1.09e-82: 257: 63.04		DYN1_HUMAN (1-864): 0: 1071: 98.03
+	Mm
		810525 SH3G1_MOUSE (1-347): 4.48e-82: 255: 62.77		DYN1_MOUSE (1-848): 0: 1066: 98.00
+	Rn
		205730 SH3G1_RAT (1-347): 2.03e-81: 254: 63.04		DYN1_RAT (1-864): 0: 1066: 100.00
+	Hs
		896873 SH3G3_HUMAN (1-347): 1.02e-94: 287: 86.74		DYN2_HUMAN (1-860): 0: 996: 78.34
+	Mm
		810540 SHLB1_MOUSE (10-342): 5.51e-67: 216: 23.93		DYN1_MOUSE (1-848): 0: 1066: 98.00
+	Hs
		1408425 SH3G3_HUMAN (1-347): 1.02e-94: 287: 86.74		DYN3_HUMAN (1-860): 0: 988: 77.78
+	Hs
		896872 SH3G2_HUMAN (1-347): 2.69e-87: 268: 66.19		DYN2_HUMAN (1-860): 0: 996: 78.34
+	Hs
		1408402 SH3G2_HUMAN (1-347): 2.69e-87: 268: 66.19		DYN3_HUMAN (1-860): 0: 988: 77.78
+	Hs
		896871 SH3G1_HUMAN (1-347): 1.09e-82: 257: 63.04		DYN2_HUMAN (1-860): 0: 996: 78.34
+	Hs
		1408384 SH3G1_HUMAN (1-347): 1.09e-82: 257: 63.04		DYN3_HUMAN (1-860): 0: 988: 77.78
+	Dm
		693527 SH3G3_DROME (1-346): 1.65e-69: 223: 48.64		DYN_DROME (6-859): 0: 951: 65.07
+	Mm
		810546 SRC8_MOUSE (7-343): 8.26e-50: 176: 12.65		DYN2_MOUSE (1-860): 0: 996: 78.68
+	Hs
		896753 SRC8_HUMAN (7-343): 2.15e-46: 167: 14.20		DYN2_HUMAN (1-860): 0: 996: 78.34
+	Ce
		73281 SH3GH_CAEEL (1-345): 1.42e-68: 221: 43.19		DYN1_CAEEL (3-802): 0: 906: 63.72
+	Hs
		135692 SH3G1_HUMAN (1-347): 1.09e-82: 257: 63.04		DNM1L_HUMAN (6-750): 0: 757: 38.77
+	Hs
		135709 SHLB2_HUMAN (10-342): 1.93e-60: 200: 21.88		DNM1L_HUMAN (6-750): 0: 757: 38.77