Protein: SHLB2
Endophilin-B2 (SH3 domain-containing GRB2-like protein B2)

Gene: SHLB2, SH3GLB2
Organism: Homo sapiens
Interactions: 92
UniProt ID: Q9NR46

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016020 - membrane
GO:0042802 - identical protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1447959

SHLB1
Endophilin-B1

12

17

Small-scale

0.985

High

1447947

SHLB2
Endophilin-B2

2

16

High-throughput

0.798

High

463236

YES
Tyrosine-protein kinase Yes

2

20

High-throughput

0.783

High

1384275

SH3K1
SH3 domain-containing kinase-binding protein 1

2

20

Small-scale

0.767

High

848181

MAGA1
Melanoma-associated antigen 1

2

4

High-throughput

0.640

High

962528

RHOA
Transforming protein RhoA

2

20

Small-scale

0.624

High

937505

CDN2D
Cyclin-dependent kinase 4 inhibitor D

1

9

High-throughput

0.621

High

1122449

GIT2
ARF GTPase-activating protein GIT2

1

9

High-throughput

0.621

High

1447954

UBQL2
Ubiquilin-2

1

5

High-throughput

0.618

High

950698

KR108
Keratin-associated protein 10-8

2

2

High-throughput

0.606

High

1235785

KR511
Keratin-associated protein 5-11

2

3

High-throughput

0.606

High

1349659

PPL13
Placental protein 13-like

2

1

High-throughput

0.606

High

1419015

KRA93
Keratin-associated protein 9-3

2

3

High-throughput

0.606

High

1419073

KRA45
Keratin-associated protein 4-5

2

3

High-throughput

0.606

High

1447950

PICK1
PRKCA-binding protein

2

2

High-throughput

0.606

High

1392926

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1447951

TBCD7
TBC1 domain family member 7

2

0

High-throughput

0.580

High

1447953

NXF1
Nuclear RNA export factor 1

2

0

High-throughput

0.580

High

1435082

ZDHC6
Palmitoyltransferase ZDHHC6

1

0

High-throughput

0.578

High

1063636

GOGA2
Golgin subfamily A member 2

1

11

High-throughput

0.560

High

900183

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.541

High

1093970

TRAF1
TNF receptor-associated factor 1

1

0

High-throughput

0.536

High

210209

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

1

High-throughput

0.536

High

317423

KPCD3
Serine/threonine-protein kinase D3

1

6

High-throughput

0.536

High

365477

PGK1
Phosphoglycerate kinase 1

1

2

High-throughput

0.536

High

530426

TAU
Microtubule-associated protein tau

1

14

High-throughput

0.536

High

1038708

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

1

High-throughput

0.536

High

1182868

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

7

High-throughput

0.536

High

1217429

OBSCN
Obscurin

1

4

High-throughput

0.536

High

1334964

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.536

High

1429205

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

1

High-throughput

0.536

High

1434684

RABE2
Rab GTPase-binding effector protein 2

1

9

High-throughput

0.536

High

1447948

MBNL1
Muscleblind-like protein 1

1

2

High-throughput

0.536

High

1447956

PA2G4
Proliferation-associated protein 2G4

1

1

High-throughput

0.536

High

1361841

RSPH1
Radial spoke head 1 homolog

1

0

High-throughput

0.518

High

562426

LAMP2
Lysosome-associated membrane glycoprotein 2

1

3

High-throughput

0.515

High

844020

HD
Huntingtin

1

7

High-throughput

0.515

High

937118

CASP6
Caspase-6

1

2

High-throughput

0.515

High

1254280

UBR3
E3 ubiquitin-protein ligase UBR3

1

0

High-throughput

0.513

High

1429757

BTBD1
BTB/POZ domain-containing protein 1

1

0

High-throughput

0.513

High

1447958

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

1447963

GMPPB
Mannose-1-phosphate guanylyltransferase catalytic subunit beta

1

0

High-throughput

0.513

High

1325763

LNX2
Ligand of Numb protein X 2

1

9

High-throughput

0.512

High

246975

KDM1A
Lysine-specific histone demethylase 1A

1

4

High-throughput

0.508

High

186051

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

1208152

CD158
Coiled-coil domain-containing protein 158

1

8

High-throughput

0.494

High

216827

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.493

High

332184

GA45G
Growth arrest and DNA damage-inducible protein GADD45 gamma

1

2

High-throughput

0.481

High

718911

CCND3
G1/S-specific cyclin-D3

1

1

High-throughput

0.481

High

949786

KR101
Keratin-associated protein 10-1

1

3

High-throughput

0.481

High

974286

LSM3
U6 snRNA-associated Sm-like protein LSm3

1

1

High-throughput

0.481

High

1087308

STX4
Syntaxin-4

1

11

High-throughput

0.481

High

1360246

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

1

3

Small-scale

0.481

High

1407477

TS101
Tumor susceptibility gene 101 protein

1

3

High-throughput

0.481

High

1447230

EXOS5
Exosome complex component RRP46

1

1

High-throughput

0.481

High

135709

DNM1L
Dynamin-1-like protein

1

20

High-throughput

0.479

High

273718

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

15

High-throughput

0.479

High

537966

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

556366

CADH1
Cadherin-1

1

6

High-throughput

0.479

High

582976

EZRI
Ezrin

1

7

High-throughput

0.479

High

877446

PIPNB
Phosphatidylinositol transfer protein beta isoform

1

2

High-throughput

0.479

High

955642

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

1093188

STK4
Serine/threonine-protein kinase 4

1

19

High-throughput

0.479

High

1247009

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

1255693

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

1314434

SLX4
Structure-specific endonuclease subunit SLX4

1

6

High-throughput

0.479

High

1446515

MED4
Mediator of RNA polymerase II transcription subunit 4

1

1

High-throughput

0.479

High

1447961

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

1447962

CEP83
Centrosomal protein of 83 kDa

1

13

High-throughput

0.479

High

519666

LYAG
Lysosomal alpha-glucosidase

1

0

High-throughput

0.460

High

1101244

NMI
N-myc-interactor

1

0

High-throughput

0.460

High

1447952

MO4L1
Mortality factor 4-like protein 1

1

0

High-throughput

0.460

High

1447955

CNOT7
CCR4-NOT transcription complex subunit 7

1

0

High-throughput

0.460

High

1447960

EXOS1
Exosome complex component CSL4

1

0

High-throughput

0.460

High

681526

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

1056990

FMR1
Fragile X messenger ribonucleoprotein 1

1

3

High-throughput

0.457

High

935170

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.445

High

1126765

BECN1
Beclin-1

1

4

High-throughput

0.445

High

1227523

A16L1
Autophagy-related protein 16-1

1

11

High-throughput

0.445

High

1447957

ITM2B
Integral membrane protein 2B

1

5

High-throughput

0.445

High

1116599

FHL3
Four and a half LIM domains protein 3

1

4

High-throughput

0.439

High

106701

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

1201965

BRDT
Bromodomain testis-specific protein

1

7

High-throughput

0.437

High

1241968

FBX42
F-box only protein 42

1

3

High-throughput

0.437

High

1278121

MAVS
Mitochondrial antiviral-signaling protein

1

17

High-throughput

0.437

High

1383691

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.437

High

1447949

FBX8
F-box only protein 8

1

4

High-throughput

0.417

High

261288

NSMA
Sphingomyelin phosphodiesterase 2

1

4

High-throughput

0.407

High

1207391

EFHC1
EF-hand domain-containing protein 1

1

0

High-throughput

0.299

High

1447710

ZN302
Zinc finger protein 302

1

0

High-throughput

0.269

Low

1314997

TEX11
Testis-expressed protein 11

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025