HitPredict

Interactor 1: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Interactor 2: SH3G2 (Q99962)
Endophilin-A1 (EEN-B1) (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2)
Gene: SH3GL2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	15834155, 17257598, 16696976
Identification Methods	pull down, surface plasmon resonance
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000139 - Golgi membrane GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction and 1 others more... GO:0098793 - presynapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 870 Hs			1 352
+	Hs
		896873 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH3G3_HUMAN (1-352): 2.72e-90: 276: 65.63
+	Hs
		896871 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH3G1_HUMAN (1-352): 9.12e-85: 262: 69.57
+	Mm
		810526 DYN1_MOUSE (1-844): 0: 1003: 79.23		SH3G2_MOUSE (1-352): 2.57e-95: 289: 98.86
+	Mm
		810527 DYN1_MOUSE (1-844): 0: 1003: 79.23		SH3G3_MOUSE (1-351): 9e-91: 277: 64.67
+	Mm
		810525 DYN1_MOUSE (1-844): 0: 1003: 79.23		SH3G1_MOUSE (1-352): 6.12e-84: 260: 69.02
+	Mm
		810546 DYN2_MOUSE (1-870): 0: 1057: 98.16		SRC8_MOUSE (7-348): 8.94e-56: 192: 13.66
+	Hs
		896753 DYN2_HUMAN (1-870): 0: 1057: 100.00		SRC8_HUMAN (7-348): 2.97e-55: 191: 14.83
+	Mm
		810540 DYN1_MOUSE (1-844): 0: 1003: 79.23		SHLB1_MOUSE (10-347): 1.08e-72: 231: 24.79
+	Hs
		896808 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH3R1_HUMAN (287-346): 1.49e-12: 70.9: 42.19
+	Mm
		810562 DYN2_MOUSE (1-870): 0: 1057: 98.16		ITSN1_MOUSE (6-349): 1.79e-12: 70.8: 12.50
+	Hs
		896763 DYN2_HUMAN (1-870): 0: 1057: 100.00		ITSN1_HUMAN (269-349): 1.86e-12: 70.8: 23.46
+	Mm
		810547 DYN2_MOUSE (1-870): 0: 1057: 98.16		GRB2_MOUSE (295-351): 1.72e-12: 67.8: 43.10
+	Hs
		896723 DYN2_HUMAN (1-870): 0: 1057: 100.00		GRB2_HUMAN (295-351): 1.52e-12: 67.8: 43.10
+	Mm
		810555 DYN2_MOUSE (1-870): 0: 1057: 98.16		SH3K1_MOUSE (280-347): 3.74e-10: 63.2: 44.00
+	Hs
		896780 DYN2_HUMAN (1-870): 0: 1057: 100.00		SH319_HUMAN (296-347): 6.78e-10: 62.4: 55.77
+	Rn
		204808 DYN2_RAT (1-870): 0: 1053: 98.05		SRBS2_RAT (295-352): 1.16e-10: 65.1: 34.72
+	Mm
		810542 DYN1_MOUSE (1-844): 0: 1003: 79.23		ITSN1_MOUSE (6-349): 1.79e-12: 70.8: 12.50
+	Mm
		810522 DYN1_MOUSE (1-844): 0: 1003: 79.23		GRB2_MOUSE (295-351): 1.72e-12: 67.8: 43.10
+	Hs
		987565 DYN1_HUMAN (1-846): 0: 1002: 79.04		GRB2_HUMAN (295-351): 1.52e-12: 67.8: 43.10
+	Mm
		810535 DYN1_MOUSE (1-844): 0: 1003: 79.23		SH3K1_MOUSE (280-347): 3.74e-10: 63.2: 44.00