HitPredict

Interactor 1: MYPT2 (O60237)
Protein phosphatase 1 regulatory subunit 12B (Myosin phosphatase-targeting subunit 2) (Myosin phosphatase target subunit 2)
Gene: PPP1R12B

Interactor 2: ANK1 (P16157)
Ankyrin-1 (ANK-1) (Ankyrin-R) (Erythrocyte ankyrin)
Gene: ANK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank~Ank_2, Ank_2~Ank_2, Ank_2~Ank_3, Ank_2~Ank_4
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0030018 - Z disc
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 982 Hs			1 1881
+	Hs
		166857 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		ANR28_HUMAN (243-938): 5.56e-164: 531: 25.37
+	Mm
		970499 ANS1B_MOUSE (62-880): 1.66e-74: 270: 16.39		ANK1_MOUSE (1-621): 8e-175: 582: 39.49
+	Hs
		225163 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		ANFY1_HUMAN (339-1001): 1.04e-74: 275: 18.41
+	Hs
		167036 ANR50_HUMAN (42-901): 1.12e-64: 240: 12.85		ANR28_HUMAN (243-938): 5.56e-164: 531: 25.37
+	Hs
		166913 ANK2_HUMAN (38-320): 2.2e-60: 228: 21.58		ANR28_HUMAN (243-938): 5.56e-164: 531: 25.37
+	Hs
		166849 ANR28_HUMAN (3-309): 3.9e-60: 225: 16.89		ANR28_HUMAN (243-938): 5.56e-164: 531: 25.37
+	Hs
		225160 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		TNKS2_HUMAN (642-1106): 5.35e-51: 200: 18.92
+	Hs
		225117 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		TNKS1_HUMAN (2-205): 9.97e-43: 174: 19.38
+	Hs
		225115 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		ANR17_HUMAN (438-755): 5.72e-32: 139: 33.33
+	Hs
		225134 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		ANK2_HUMAN (808-1879): 2.96e-13: 78: 10.00
+	Hs
		225146 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		ANKH1_HUMAN (9-166): 1.11e-11: 72.8: 33.33
+	Hs
		225136 MYPT2_HUMAN (1-982): 7.66e-163: 505: 100.00		ANK3_HUMAN (1113-1875): 2.27e-11: 71.8: 11.59
+	Hs
		166869 ANR28_HUMAN (3-309): 3.9e-60: 225: 16.89		TNKS1_HUMAN (2-205): 9.97e-43: 174: 19.38
+	Hs
		883487 RIPK4_HUMAN (21-365): 7.55e-66: 239: 21.07		ANK2_HUMAN (808-1879): 2.96e-13: 78: 10.00
+	Hs
		965154 Q9H4D1_HUMAN (21-365): 2.96e-65: 237: 21.07		ANK2_HUMAN (808-1879): 2.96e-13: 78: 10.00
+	Hs
		883496 RIPK4_HUMAN (21-365): 7.55e-66: 239: 21.07		ANK3_HUMAN (1113-1875): 2.27e-11: 71.8: 11.59
+	Hs
		1021462 Q9H4D1_HUMAN (21-365): 2.96e-65: 237: 21.07		ANK3_HUMAN (1113-1875): 2.27e-11: 71.8: 11.59
+	Hs
		257652 ANR17_HUMAN (2-882): 9.92e-62: 232: 12.57		ANKH1_HUMAN (9-166): 1.11e-11: 72.8: 33.33
+	Hs
		166919 ANR28_HUMAN (3-309): 3.9e-60: 225: 16.89		ANK3_HUMAN (1113-1875): 2.27e-11: 71.8: 11.59