HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: NMDZ1 (Q05586)
Glutamate receptor ionotropic, NMDA 1 (GluN1) (Glutamate [NMDA] receptor subunit zeta-1) (N-methyl-D-aspartate receptor subunit NR1) (NMD-R1)
Gene: GRIN1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	30200940
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0014069 - postsynaptic density GO:0043005 - neuron projection GO:0044877 - protein-containing complex binding GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 938
+	Hs
		227314 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GRIK2_HUMAN (3-901): 0: 745: 22.55
+	Mm
		761223 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		GRIK2_MOUSE (3-901): 0: 742: 22.55
+	Hs
		226753 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GRIA1_HUMAN (6-904): 0: 703: 21.38
+	Hs
		227344 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NMDE2_HUMAN (4-938): 0: 661: 23.83
+	Hs
		227565 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GRIK4_HUMAN (10-867): 0: 654: 23.18
+	Hs
		227573 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GRIK5_HUMAN (9-898): 0: 627: 23.18