HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	21095585, 29667579, 30884854, 34581668, 38803224
Identification Methods	x-ray crystallography, enzymatic study, pull down
Interaction Type	association, direct interaction

Property	Details
Interacting Pfam domains	UQ_con~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 685 Hs			1 147
+	Hs
		476604 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D4_HUMAN (1-147): 1.29e-82: 241: 91.84
+	Hs
		475586 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D2_HUMAN (1-147): 7.7e-82: 238: 89.12
+	Hs
		475550 UBC_HUMAN (1-685): 0: 846: 100.00		UB2D3_HUMAN (1-147): 9.08e-81: 236: 88.44
+	Hs
		476218 UBC_HUMAN (1-685): 0: 846: 100.00		UB2E2_HUMAN (4-146): 3.11e-74: 221: 62.94
+	Hs
		476155 UBC_HUMAN (1-685): 0: 846: 100.00		UB2E3_HUMAN (4-146): 1.2e-73: 220: 62.94
+	Hs
		475504 UBC_HUMAN (1-685): 0: 846: 100.00		UB2E1_HUMAN (4-146): 3.94e-72: 216: 62.94
+	Hs
		475485 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2A_HUMAN (2-144): 2.83e-70: 209: 40.56
+	Hs
		475597 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2B_HUMAN (2-144): 1.35e-69: 208: 39.16
+	Hs
		475552 UBC_HUMAN (1-685): 0: 846: 100.00		UBE2N_HUMAN (4-147): 1.92e-68: 205: 45.83
+	Xl
		919927 Q7SY79_XENLA (77-685): 0: 744: 99.84		UB2D2_XENLA (1-147): 7.7e-82: 238: 89.12
+	Dm
		639414 Q9W418_DROME (229-685): 0: 557: 99.78		UBCD1_DROME (1-147): 1.87e-81: 238: 89.12
+	Sc
		477103 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC4_YEAST (3-147): 3.9e-79: 232: 79.31
+	Sc
		477123 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		UBC1_YEAST (4-146): 2.12e-43: 144: 46.21
+	At
		1091932 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC28_ARATH (1-147): 6.9e-83: 241: 76.19
+	At
		715116 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC8_ARATH (1-147): 3.61e-82: 239: 76.19
+	At
		715157 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC11_ARATH (1-147): 6.25e-82: 239: 76.19
+	At
		715132 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC9_ARATH (1-147): 8.78e-82: 238: 77.55
+	At
		715147 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC10_ARATH (1-147): 9.28e-82: 238: 76.87
+	At
		639385 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC1_ARATH (2-144): 9.44e-70: 208: 45.46
+	At
		790155 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		UBC2_ARATH (2-144): 7.41e-70: 208: 45.46