HitPredict

Interactor 1: UBC (P0CG48)
Polyubiquitin-C [Cleaved into: Ubiquitin]
Gene: UBC

Interactor 2: IKKE (Q14164)
Inhibitor of nuclear factor kappa-B kinase subunit epsilon (I-kappa-B kinase epsilon) (IKK-E) (IKK-epsilon) (IkBKE) (EC 2.7.11.10) (Inducible I kappa-B kinase) (IKK-i)
Gene: IKBKE

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

Property	Details
Experiments	19380491, 27622505, 24882218, 18636086
Identification Methods	pull down, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 685 Hs			1 716
+	Hs
		476524 UBC_HUMAN (1-685): 0: 846: 100.00		TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13
+	Hs
		158377 UBC_HUMAN (1-685): 0: 846: 100.00		IKKB_HUMAN (9-701): 6.33e-128: 399: 18.97
+	Hs
		167451 UBC_HUMAN (1-685): 0: 846: 100.00		IKKA_HUMAN (9-700): 5.05e-116: 367: 18.31
+	Hs
		262227 UBC_HUMAN (1-685): 0: 846: 100.00		ULK1_HUMAN (2-221): 1.05e-23: 109: 31.72
+	Sc
		419769 UBI4P_YEAST (381-685): 5e-122: 370: 95.74		SNF1_YEAST (9-487): 5.7e-101: 325: 17.23
+	At
		1091641 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		KIN10_ARATH (9-469): 1.39e-121: 374: 17.42
+	At
		1091642 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		CDPKB_ARATH (3-372): 1.93e-120: 371: 16.45
+	Mm
		477048 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		IKKE_MOUSE (1-716): 1.49e-161: 485: 82.34
+	Hs
		475222 UBB_HUMAN (1-77): 7.83e-26: 108: 98.70		TBK1_HUMAN (1-714): 4.2e-162: 486: 48.13
+	At
		955189 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		KIN11_ARATH (9-284): 3.78e-84: 277: 23.84
+	Mm
		291435 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		IKKB_MOUSE (9-701): 1.41e-126: 395: 19.10
+	Mm
		476818 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		IKKA_MOUSE (9-700): 5.3e-115: 365: 18.72
+	At
		98421 UBQ3_ARATH (457-685): 3.23e-85: 272: 95.63		RUK_ARATH (9-222): 2.52e-23: 108: 34.72
+	Mm
		250791 UBC_MOUSE (1-108): 9.43e-30: 127: 90.74		ULK1_MOUSE (1-221): 1.63e-23: 108: 31.58