HitPredict

Interactor 1: K2C7 (P08729)
Keratin, type II cytoskeletal 7 (Cytokeratin-7) (CK-7) (Keratin-7) (K7) (Sarcolectin) (Type-II keratin Kb7)
Gene: KRT7

Interactor 2: K1C20 (P35900)
Keratin, type I cytoskeletal 20 (Cytokeratin-20) (CK-20) (Keratin-20) (K20) (Protein IT)
Gene: KRT20

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35575683
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Filament~Filament
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005882 - intermediate filament GO:0045109 - intermediate filament organization GO:0045111 - intermediate filament cytoskeleton
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 469 Hs			1 424
+	Hs
		437109 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K1C20_HUMAN (1-424): 8.19e-156: 448: 100.00
+	Hs
		436763 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K1C18_HUMAN (1-415): 1.84e-141: 412: 44.03
+	Hs
		385035 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K1C14_HUMAN (68-418): 1.21e-138: 406: 54.80
+	Hs
		437088 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K1C15_HUMAN (69-420): 4.32e-135: 396: 52.13
+	Hs
		437152 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K1C17_HUMAN (64-418): 2.36e-135: 396: 55.21
+	Hs
		437062 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K1C19_HUMAN (59-378): 1.35e-103: 314: 55.63
+	Hs
		437076 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K1C13_HUMAN (63-380): 5.81e-102: 312: 56.74
+	Hs
		49878 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		A1A4E9_HUMAN (63-380): 1.73e-101: 311: 56.43
+	Hs
		437064 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K1C16_HUMAN (66-387): 5.08e-100: 308: 56.52
+	Hs
		227198 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		KRT86_HUMAN (8-396): 2.3e-95: 296: 24.75
+	Hs
		341724 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K2C75_HUMAN (32-393): 2.49e-92: 290: 25.28
+	Hs
		300259 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		KT33A_HUMAN (66-380): 3.15e-93: 288: 49.84
+	Hs
		437171 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		KT33B_HUMAN (66-380): 2.94e-92: 285: 49.84
+	Hs
		300282 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		KRT34_HUMAN (66-380): 5.38e-92: 284: 49.52
+	Hs
		300545 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		KRT36_HUMAN (2-424): 7.12e-83: 263: 43.69
+	Hs
		407237 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K2C6B_HUMAN (35-397): 2.09e-81: 262: 23.84
+	Hs
		437077 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K2C5_HUMAN (35-384): 5.13e-81: 262: 25.57
+	Hs
		437121 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K2C6C_HUMAN (35-397): 1.96e-81: 262: 24.11
+	Hs
		437172 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K1H2_HUMAN (12-393): 6.36e-82: 260: 43.72
+	Hs
		385216 K2C8_HUMAN (1-439): 8.81e-161: 465: 61.28		K2C6A_HUMAN (35-397): 7.14e-80: 258: 24.11