HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: RNF8 (O76064)
E3 ubiquitin-protein ligase RNF8 (hRNF8) (EC 2.3.2.27) (RING finger protein 8) (RING-type E3 ubiquitin transferase RNF8)
Gene: RNF8

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.38 1.00 0.618

The method score is based on:

Property Details
Experiments 35256949
Identification Methods affinity chromatography technology
Interaction Type physical association

The annotation score is based on:

Property Details
Interacting Pfam domains ubiquitin~zf-C3HC4_3
Common GO terms GO:0000151 - ubiquitin ligase complex
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0008270 - zinc ion binding
and 7 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 465
Hs

1 485
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Service provided by Combinatics, Japan

Last updated: 11Aug2025