HitPredict

Interactor 1: P85A (P26450)
Phosphatidylinositol 3-kinase regulatory subunit alpha (PI3-kinase regulatory subunit alpha) (PI3K regulatory subunit alpha) (PtdIns-3-kinase regulatory subunit alpha) (Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha) (PI3-kinase subunit p85-alpha) (PtdIns-3-kinase regulatory subunit p85-alpha)
Gene: Pik3r1

Interactor 2: DOK1 (P97465)
Docking protein 1 (Downstream of tyrosine kinase 1) (p62(dok))
Gene: DOK1

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	11031258
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 724 Mm			1 482
+	Hs
		699839 P85A_HUMAN (1-724): 0: 553: 94.35		DOK1_HUMAN (1-482): 0: 526: 83.44
+	Hs
		160420 P85A_HUMAN (1-724): 0: 553: 94.35		IRS4_HUMAN (6-406): 7.56e-92: 305: 14.29
+	Mm
		686950 P85A_MOUSE (1-724): 0: 564: 100.00		IRS2_MOUSE (6-370): 2.18e-73: 253: 13.82
+	Mm
		686938 P85A_MOUSE (1-724): 0: 564: 100.00		IRS1_MOUSE (6-365): 2.63e-70: 244: 16.27
+	Hs
		699905 P85A_HUMAN (1-724): 0: 553: 94.35		IRS2_HUMAN (6-368): 7.81e-71: 246: 12.78
+	Rn
		98921 P85A_RAT (1-724): 0: 548: 96.13		F1MAL5_RAT (6-370): 1.9e-72: 251: 13.82
+	Rn
		772591 P85A_RAT (1-724): 0: 548: 96.13		IRS1_RAT (6-365): 6.75e-71: 246: 16.27
+	Hs
		699616 P85A_HUMAN (1-724): 0: 553: 94.35		IRS1_HUMAN (6-360): 6.41e-68: 237: 16.01
+	Hs
		136230 P85B_HUMAN (4-719): 7.25e-153: 463: 57.10		IRS4_HUMAN (6-406): 7.56e-92: 305: 14.29
+	Mm
		1021483 BCR_MOUSE (8-292): 7.19e-58: 215: 17.30		DOK1_MOUSE (1-482): 0: 545: 100.00
+	Rn
		148123 P85A_RAT (1-724): 0: 548: 96.13		O08724_RAT (7-314): 1.52e-61: 210: 19.45
+	Hs
		540078 BCR_HUMAN (8-292): 6.41e-57: 212: 17.30		DOK1_HUMAN (1-482): 0: 526: 83.44
+	Hs
		136310 P85B_HUMAN (4-719): 7.25e-153: 463: 57.10		IRS1_HUMAN (6-360): 6.41e-68: 237: 16.01
+	Hs
		160568 P55G_HUMAN (271-723): 3.1e-91: 294: 72.31		IRS4_HUMAN (6-406): 7.56e-92: 305: 14.29
+	Hs
		1364903 P55G_HUMAN (271-723): 3.1e-91: 294: 72.31		IRS2_HUMAN (6-368): 7.81e-71: 246: 12.78
+	Hs
		772510 P55G_HUMAN (271-723): 3.1e-91: 294: 72.31		IRS1_HUMAN (6-360): 6.41e-68: 237: 16.01
+	Mm
		267119 BCR_MOUSE (8-292): 7.19e-58: 215: 17.30		DOK2_MOUSE (2-425): 3.73e-101: 311: 33.11
+	Hs
		220286 P55G_HUMAN (271-723): 3.1e-91: 294: 72.31		FRS3_HUMAN (135-480): 5.73e-67: 224: 19.11
+	Hs
		160550 RHG24_HUMAN (104-381): 2.69e-57: 209: 20.00		IRS4_HUMAN (6-406): 7.56e-92: 305: 14.29
+	Dm
		1466645 SRC42_DROME (556-723): 2.63e-28: 121: 24.72		Q9W3R6_DROME (1-257): 3.28e-59: 207: 25.38